KEGG   ORTHOLOGY: K01702
Entry
K01702                      KO                                     
Symbol
LEU1
Name
3-isopropylmalate dehydratase [EC:4.2.1.33]
Pathway
map00290  Valine, leucine and isoleucine biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
Module
M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Reaction
R03968  2-isopropylmalate hydro-lyase
R04001  3-isopropylmalate hydro-lyase
R10170  (2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00290 Valine, leucine and isoleucine biosynthesis
    K01702  LEU1; 3-isopropylmalate dehydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.33  3-isopropylmalate dehydratase
     K01702  LEU1; 3-isopropylmalate dehydratase
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K01702
Other DBs
COG: COG0065 COG0066
GO: 0003861
Genes
AJM: 119044120
OLU: OSTLU_28677
OTA: OT_ostta03g02820
BPG: Bathy01g00570
MIS: MICPUN_96879
MPP: MICPUCDRAFT_31575(JGI:MicpuC2_31575)
SCE: YGL009C(LEU1)
SEUB: DI49_1958
SPAO: SPAR_G02250
AGO: AGOS_AGR169W
ERC: Ecym_7230
KLA: KLLA0_A04961g
KMX: KLMA_50154(LEU1)
LTH: KLTH0E07722g
VPO: Kpol_1025p41
ZRO: ZYRO0G10076g
CGR: CAGL0A00363g
NCS: NCAS_0A01660(NCAS0A01660) NCAS_0A03480(NCAS0A03480)
NDI: NDAI_0A03320(NDAI0A03320) NDAI_0D03580(NDAI0D03580)
TPF: TPHA_0K01610(TPHA0K01610)
TBL: TBLA_0A09030(TBLA0A09030)
TGB: HG536_0D04470 HG536_0F00100
TDL: TDEL_0F02390(TDEL0F02390)
KAF: KAFR_0F03440(KAFR0F03440)
KNG: KNAG_0C02900(KNAG0C02900) KNAG_0D03560(KNAG0D03560)
ZMK: HG535_0E03970
PPA: PAS_chr2-1_0368
DHA: DEHA2C11660g
PIC: PICST_68659(LEU1)
PGU: PGUG_01147
SPAA: SPAPADRAFT_134446
LEL: PVL30_000031(LEU1)
CAL: CAALFM_CR00360CA(LEU1)
CTP: CTRG_01045
COT: CORT_0A00440
CDU: CD36_25490(LEU1)
CTEN: CANTEDRAFT_94029
YLI: YALI0B01364g
CLU: CLUG_05286
CLUS: A9F13_14g00583
CAUR: CJI96_0004373
SLB: AWJ20_4087(LEU1)
PKZ: C5L36_0B06020
BNN: FOA43_003350(LEU1)
BBRX: BRETT_004196(LEU1)
OPA: HPODL_02442
SLUD: SCDLUD_001491
NCR: NCU04385(leu-2)
NTE: NEUTE1DRAFT60808(NEUTE1DRAFT_60808)
SMP: SMAC_01760
PAN: PODANSg6185
PBEL: QC761_303650(LEU1)
PPSD: QC762_303650(LEU1)
PPSP: QC763_303650(LEU1)
PPSA: QC764_303650(LEU1)
TTT: THITE_2115823
MTM: MYCTH_2299349
CTHR: CTHT_0030240
MGR: MGG_01553
PPEI: PpBr36_01071
PGRI: PgNI_03948
TMN: UCRPA7_6869
SSCK: SPSK_03984
FGR: FGSG_09589
FPU: FPSE_05867
FPOA: FPOAC1_012067
FVN: FVRRES_13136
FVR: FVEG_04144
FOX: FOXG_06292
NHE: NECHADRAFT_32154
FFC: NCS54_00275300
FKR: NCS57_00271100
FMU: J7337_004148
TRE: TRIREDRAFT_75000
TRR: M419DRAFT_135773
MAW: MAC_07916
MAJ: MAA_10405
PCHM: VFPPC_03922
CMT: CCM_04181
AMUS: LMH87_006420
PLJ: VFPFJ_00798
PTKZ: JDV02_007859(LEU1)
VAL: VDBG_00954
VDA: VDAG_00564
CFJ: CFIO01_12582
CLUP: CLUP02_17581
CHIG: CH63R_07860
SAPO: SAPIO_CDS7042
ELA: UCREL1_4882
PFY: PFICI_04652
BFU: BCIN_07g06550(Bcleu1)
MBE: MBM_06603
PSCO: LY89DRAFT_689522
GLZ: GLAREA_01994
ANI: ANIA_05886
AFM: AFUA_2G11260
ACT: ACLA_070230
NFI: NFIA_086540
AOR: AO090026000524
ANG: An02g03250
AFV: AFLA_005752
ALUC: AKAW2_21345A(LEU1)
ACHE: ACHE_40645S(LEU1)
APUU: APUU_10901A(LEU1)
PCS: N7525_009993
PDP: PDIP_10750
POU: POX_e07129
TMF: EYB26_003577
TRG: TRUGW13939_07745 TRUGW13939_08759
CIM: CIMG_13255(CIMG08205)
CPW: CPC735_022220
PBL: PAAG_03296
PBN: PADG_03167
ABE: ARB_01330
TVE: TRV_07374
AJE: HCAG_07104
BGH: BDBG_00593
PNO: SNOG_13672
PTE: PTT_09557 PTT_11255
BZE: COCCADRAFT_34094
BSC: COCSADRAFT_36104
BOR: COCMIDRAFT_27295
AALT: CC77DRAFT_955795
ARAB: EKO05_0011035
ZTR: MYCGRDRAFT_109538
PFJ: MYCFIDRAFT_51855
FFU: CLAFUR5_08248
CBET: CB0940_04244
BCOM: BAUCODRAFT_245692
NPA: UCRNP2_129
TML: GSTUM_00006413001
SPO: SPAC9E9.03(leu2)
SOM: SOMG_02879(leu2)
CNE: CNA02270
CNB: CNBA2130
CNG: CNAG_00237
CGI: CGB_B2610W
CDEU: CNBG_0330
TMS: TREMEDRAFT_29353
TASA: A1Q1_05818
CCAC: CcaHIS019_0106750(LEU1)
TVS: TRAVEDRAFT_163369 TRAVEDRAFT_39797
DSQ: DICSQDRAFT_135275
PCO: PHACADRAFT_250234
SHS: STEHIDRAFT_120665
HIR: HETIRDRAFT_62958
PSQ: PUNSTDRAFT_142715
ADL: AURDEDRAFT_110518 AURDEDRAFT_183015
FME: FOMMEDRAFT_142649 FOMMEDRAFT_169383 FOMMEDRAFT_21650
GTR: GLOTRDRAFT_136258
RSX: RhiXN_04503
LBC: LACBIDRAFT_292982
CCI: CC1G_00469
ABP: AGABI1DRAFT113428(AGABI1DRAFT_113428)
ABV: AGABI2DRAFT191925(AGABI2DRAFT_191925)
PCUB: JR316_0004972
MRR: Moror_17609
MORE: E1B28_004537
SCM: SCHCO_02540071(SCHCODRAFT_02540071)
CPUT: CONPUDRAFT_126359 CONPUDRAFT_81749
SLA: SERLADRAFT_360155
WSE: WALSEDRAFT_59873
WIC: J056_004763
UMA: UMAG_06010
PFP: PFL1_06208
SGRA: EX895_003483
MGL: MGL_1144
MRT: MRET_3007
MSYM: MSY001_0729
PGR: PGTG_03290
PTRC: PtA15_11A533 PtA15_1A961
PSTR: Pst134EA_000102 Pst134EA_011722
MLR: MELLADRAFT_44992
SMIN: v1.2.006892.t1(symbB.v1.2.006892.t1)
PTI: PHATRDRAFT_24772
FCY: FRACYDRAFT_223273(IPMI)
TPS: THAPSDRAFT_42704(LEU2)
AAF: AURANDRAFT_27414
EHX: EMIHUDRAFT_421960
GTT: GUITHDRAFT_92507
DEX: HWD60_07195(leuC)
 » show all
Reference
PMID:12626680
  Authors
Kohlhaw GB
  Title
Leucine biosynthesis in fungi: entering metabolism through the back door.
  Journal
Microbiol Mol Biol Rev 67:1-15, table of contents (2003)
DOI:10.1128/MMBR.67.1.1-15.2003
  Sequence
[sce:YGL009C]
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