KEGG   ORTHOLOGY: K01906
Entry
K01906                      KO                                     
Symbol
bioW
Name
6-carboxyhexanoate--CoA ligase [EC:6.2.1.14]
Pathway
map00780  Biotin metabolism
map01100  Metabolic pathways
map01240  Biosynthesis of cofactors
Module
M00577  Biotin biosynthesis, BioW pathway, pimelate => pimeloyl-CoA => biotin
Reaction
R03209  6-carboxyhyxanoate:CoA ligase (AMP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00780 Biotin metabolism
    K01906  bioW; 6-carboxyhexanoate--CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.14  6-carboxyhexanoate---CoA ligase
     K01906  bioW; 6-carboxyhexanoate--CoA ligase
Other DBs
COG: COG1424
GO: 0042410
Genes
MALU: KU6B_03740
GHC: L9S41_06245
PCA: Pcar_1666(bioW)
PACE: A6070_06910
PEF: A7E78_02755
DEU: DBW_2418(bioW)
DVE: DESUT3_28120(bioW)
DES: DSOUD_1422
DDS: Ddes_0424
DFI: AXF13_07405
TPI: TREPR_3053(bioW)
FSC: FSU_0221(bioW)
AAE: aq_1659(bioW)
HTH: HTH_1774(bioW)
TAL: Thal_1538
SAF: SULAZ_1395(bioW)
PMX: PERMA_1854(bioW)
TYE: THEYE_A0810(bioW)
DTP: JZK55_14060(bioW)
LFC: LFE_0971
LFI: LFML04_1509(bioW)
BSU: BSU30240(bioW)
BSR: I33_3078(bioW)
BSL: A7A1_1652
BSH: BSU6051_30240(bioW)
BSUT: BSUB_03213(bioW)
BSUL: BSUA_03213(bioW)
BSUS: Q433_16400
BSQ: B657_30240(bioW)
BSX: C663_2869(bioW)
BSS: BSUW23_14650(bioW)
BST: GYO_3272(bioW)
BLI: BL02411(bioW)
BLD: BLi00766(bioW)
BLH: BaLi_c08640(bioW)
BYA: BANAU_1954(bioW)
BQY: MUS_2183(bioW)
BAMP: B938_09460
BAML: BAM5036_1766(bioW)
BAMA: RBAU_1804(bioW)
BAMN: BASU_1784(bioW)
BAMB: BAPNAU_1915(bioW)
BAMT: AJ82_10390
BAMY: V529_17990(bioW)
BMP: NG74_01905(bioW)
BAO: BAMF_1924(bioW)
BAZ: BAMTA208_07885(bioW)
BQL: LL3_02014(bioW)
BXH: BAXH7_01606(bioW)
BAMI: KSO_010220
BAMC: U471_18840
BAMF: U722_09675
BSON: S101395_00961(bioW)
BHT: DIC78_16480(bioW)
BMOJ: HC660_28880(bioW)
BSTR: QI003_18320(bioW)
BGY: BGLY_0780
BCAB: EFK13_15365(bioW)
BRY: M0696_15075(bioW)
BJS: MY9_3024
BACP: SB24_00510
BACB: OY17_12280
BACO: OXB_3347
BACY: QF06_13310
BACL: BS34A_32880(bioW)
BALM: BsLM_3008
BACQ: DOE78_13830(bioW)
BKN: WDJ61_01635(bioW)
BEO: BEH_11230
BKW: BkAM31D_02740(bioW)
BPF: BpOF4_16065(bioW)
LYQ: MY533_10705(bioW)
HSHI: MUO14_17890(bioW)
VPN: A21D_01033(bioW)
PASA: BAOM_1991
MSEM: GMB29_11985(bioW)
ROSS: V2W31_17285(bioW)
DOM: RRU94_17185(bioW)
SAU: SA2211
SAV: SAV2423
SAW: SAHV_2407
SAM: MW2346
SAS: SAS2314
SAR: SAR2513
SAC: SACOL2424(bioW)
SAX: USA300HOU_2407(bioW)
SAE: NWMN_2322(bioW)
SAD: SAAV_2489(bioW)
SUZ: MS7_2438
SUG: SAPIG2476
SAUA: SAAG_00250
SAUE: RSAU_002262(bioW)
SAUS: SA40_2173
SAUU: SA957_2257
SAUG: SA268_2330
SAUT: SAI1T1_2017980(bioW)
SAUJ: SAI2T2_1017990(bioW)
SAUK: SAI3T3_1017980(bioW)
SAUQ: SAI4T8_1017990(bioW)
SAUV: SAI7S6_1017980(bioW)
SAUW: SAI5S5_1017920(bioW)
SAUX: SAI6T6_1017920(bioW)
SAUY: SAI8T7_1017960(bioW)
SAUF: X998_2409
SAB: SAB2304c
SAUB: C248_2471
SAUC: CA347_2503
SAUR: SABB_02993(bioW)
SAUI: AZ30_12740
SAUD: CH52_06865
SAMS: NI36_12020
SER: SERP2393(bioW)
SEP: SE_0182
SEPP: SEB_00113
SEPS: DP17_1279
SDT: SPSE_0126(bioW)
SDP: NCTC12225_00148(bioW)
SHU: SHYC_01065(bioW)
SSCH: LH95_00995
SSCZ: RN70_01215
SAGQ: EP23_09060
SSH: NCTC13712_02374(bioW)
ASOC: CB4_02730(bioW)
AUD: PO771_10355(bioW)
ANEU: PP175_00220(bioW)
SPAE: E2C16_15325(bioW)
CACE: CACET_c13450(bioW)
CTHM: CFE_1510
RTO: RTO_04560
RHOM: FRIFI_1195
TMY: TEMA_34050(bioW)
TKI: TKV_c07350(bioW)
NCJ: MCACP_13450(bioW)
PHAR: NCTC13077_01223(bioW)
CAD: Curi_c25540(bioW)
VPR: Vpar_1006
VRM: 44547418_01018(bioW)
VDN: NCTC11831_00891(bioW)
VNK: VEIT17_08280(bioW)
VOR: VEIS_07530(bioW)
DHO: Dia5BBH33_18170(bioW)
SRI: SELR_03060(bioWF)
MHG: MHY_24740
PUF: UFO1_4053
STED: SPTER_12670(bioW)
SSPH: SPSPH_013050(bioW)
SOVA: SOV_12430(bioW)
SSID: SPSIL_017850(bioW)
SCAO: SCACP_11870(bioW)
PFAC: PFJ30894_02090(bioW)
CDI: DIP1381
CDIP: ERS451417_01397(bioW)
CKP: ckrop_1506(bioWF)
CPL: Cp3995_1206(bioW)
CPP: CpP54B96_1201(bioW)
CPZ: CpPAT10_1177(bioW)
COR: Cp267_1234(bioW)
COD: Cp106_1161(bioW)
COS: Cp4202_1171(bioW)
CPSE: CPTA_01755
CPSU: CPTB_02008
CPSF: CPTC_01746
CUL: CULC22_01291(bioW)
CUC: CULC809_01277(bioW)
CUE: CULC0102_1406(bioW)
CUN: Cul210932_1345(bioW)
CUQ: Cul210931_1242(bioW)
CUZ: Cul05146_1318(bioW)
CUJ: CUL131002_1273(bioW)
CUS: CulFRC11_1258(bioW)
COA: DR71_1458(bioF)
CSP: WM42_2495
CPHO: CPHO_10675
CMIN: NCTC10288_01030(bioW)
CPEG: CPELA_04945(bioW)
CGK: CGERO_06225(bioW)
CPSO: CPPEL_05150(bioW)
CKW: CKALI_03420(bioW)
CACC: CACC_08710(bioW)
CMAS: CMASS_00810(bioW)
CIHU: CIHUM_06695(bioW)
CHAD: CHAD_09610(bioW)
CFOU: CFOUR_06755(bioW)
CFEU: CFELI_06080(bioW)
CAFE: CAFEL_06640(bioW)
CGOI: CGOTT_09260(bioW)
PAC: PPA1866
PAW: PAZ_c19410(bioF)
PACC: PAC1_09540
PACH: PAGK_1785
CACN: RN83_09625
CGRN: 4412665_00276(bioW)
MJA: MJ_1297
MESG: MLAUSG7_1138(bioW)
MESA: MLASG1_0637(bioW)
MMP: MMP1575(bioW)
MMD: GYY_08730
MMAK: MMKA1_18050(bioW)
MMAO: MMOS7_16870(bioW)
MMAD: MMJJ_12610(bioW)
MAE: Maeo_1420
MVO: Mvol_1143
MRU: mru_2041(bioW)
MOL: YLM1_1481
 » show all
Reference
PMID:8763940
  Authors
Bower S, Perkins JB, Yocum RR, Howitt CL, Rahaim P, Pero J
  Title
Cloning, sequencing, and characterization of the Bacillus subtilis biotin biosynthetic operon.
  Journal
J Bacteriol 178:4122-30 (1996)
DOI:10.1128/JB.178.14.4122-4130.1996
  Sequence
[bsu:BSU30240]
Reference
PMID:1445232
  Authors
Ploux O, Soularue P, Marquet A, Gloeckler R, Lemoine Y
  Title
Investigation of the first step of biotin biosynthesis in Bacillus sphaericus. Purification and characterization of the pimeloyl-CoA synthase, and uptake of pimelate.
  Journal
Biochem J 287 ( Pt 3):685-90 (1992)
DOI:10.1042/bj2870685
LinkDB

KEGG   ENZYME: 6.2.1.14
Entry
EC 6.2.1.14                 Enzyme                                 
Name
6-carboxyhexanoate---CoA ligase;
6-carboxyhexanoyl-CoA synthetase;
pimelyl-CoA synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
6-carboxyhexanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA [RN:R03209]
Reaction(KEGG)
R03209
Substrate
ATP [CPD:C00002];
6-carboxyhexanoate [CPD:C02656];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
6-carboxyhexanoyl-CoA [CPD:C01063]
History
EC 6.2.1.14 created 1983
Pathway
ec00780  Biotin metabolism
ec01100  Metabolic pathways
Orthology
K01906  6-carboxyhexanoate--CoA ligase
Genes
MALUKU6B_03740
GHCL9S41_06245
PCAPcar_1666(bioW)
PACEA6070_06910
PEFA7E78_02755
DEUDBW_2418(bioW)
DVEDESUT3_28120(bioW)
DESDSOUD_1422
DDSDdes_0424
DFIAXF13_07405
AAGGETAA8_58000
TPITREPR_3053(bioW)
TRIDYE50_09460
FSUFisuc_2956
FSCFSU_0221(bioW)
AAEaq_1659(bioW)
HYAHY04AAS1_0813
HHOHydHO_0808
HYSHydSN_0825
HTHHTH_1774(bioW)
HTEHydth_1756
TALThal_1538
TRDTHERU_03735
SULSYO3AOP1_1703
SAFSULAZ_1395(bioW)
PMXPERMA_1854(bioW)
TAMTheam_0831
DTEDester_0730
TYETHEYE_A0810(bioW)
TOBV4D31_06460
TAUTV4D30_01505
DTPJZK55_14060(bioW)
LFCLFE_0971
LFILFML04_1509(bioW)
LFPY981_07525
LEGABH19_05580
BSUBSU30240(bioW)
BSRI33_3078(bioW)
BSLA7A1_1652
BSHBSU6051_30240(bioW)
BSYI653_14475
BSUTBSUB_03213(bioW)
BSULBSUA_03213(bioW)
BSUSQ433_16400
BSOBSNT_09444
BSNBSn5_05960
BSQB657_30240(bioW)
BSXC663_2869(bioW)
BSPU712_15010
BSSBSUW23_14650(bioW)
BSTGYO_3272(bioW)
BITBIS30_04490
BLIBL02411(bioW)
BLDBLi00766(bioW)
BLHBaLi_c08640(bioW)
BAYRBAM_018290
BYABANAU_1954(bioW)
BQYMUS_2183(bioW)
BAMPB938_09460
BAMLBAM5036_1766(bioW)
BAMARBAU_1804(bioW)
BAMNBASU_1784(bioW)
BAMBBAPNAU_1915(bioW)
BAMTAJ82_10390
BAMYV529_17990(bioW)
BMPNG74_01905(bioW)
BAOBAMF_1924(bioW)
BAZBAMTA208_07885(bioW)
BQLLL3_02014(bioW)
BXHBAXH7_01606(bioW)
BAMIKSO_010220
BAMCU471_18840
BAMFU722_09675
BSIACWD84_11850
BAEBATR1942_12910
BVMB9C48_09335
BSONS101395_00961(bioW)
BHTDIC78_16480(bioW)
BMOJHC660_28880(bioW)
BIQAN935_15135
BSTRQI003_18320(bioW)
BGYBGLY_0780
BCABEFK13_15365(bioW)
BRYM0696_15075(bioW)
BJSMY9_3024
BACPSB24_00510
BACBOY17_12280
BACOOXB_3347
BACYQF06_13310
BACLBS34A_32880(bioW)
BALMBsLM_3008
BACSAUL54_01440
BACQDOE78_13830(bioW)
BAFCK3G25_17145
BKNWDJ61_01635(bioW)
BEOBEH_11230
BFXBC359_10250
BKWBkAM31D_02740(bioW)
BGIBGM20_09070
BPFBpOF4_16065(bioW)
LGYT479_02545
LYQMY533_10705(bioW)
HSHIMUO14_17890(bioW)
VPNA21D_01033(bioW)
APAKAP3564_14135
PASABAOM_1991
MSEMGMB29_11985(bioW)
ROSSV2W31_17285(bioW)
ALKLMM271_06855
DOMRRU94_17185(bioW)
SAUSA2211
SAVSAV2423
SAWSAHV_2407
SAHSaurJH1_2497
SAJSaurJH9_2449
SAMMW2346
SASSAS2314
SARSAR2513
SACSACOL2424(bioW)
SAXUSA300HOU_2407(bioW)
SAASAUSA300_2369
SAOSAOUHSC_02712
SAENWMN_2322(bioW)
SADSAAV_2489(bioW)
SUUM013TW_2385
SUVSAVC_10990
SUESAOV_2472c
SUJSAA6159_02324
SUCECTR2_2282
SUTSAT0131_02618
SUQHMPREF0772_10764
SUZMS7_2438
SUDST398NM01_2476
SUXSAEMRSA15_23220
SUWSATW20_25530
SUGSAPIG2476
SUFSARLGA251_22050
SAUASAAG_00250
SAUERSAU_002262(bioW)
SAUNSAKOR_02404
SAUSSA40_2173
SAUUSA957_2257
SAUGSA268_2330
SAUZSAZ172_2528
SAUTSAI1T1_2017980(bioW)
SAUJSAI2T2_1017990(bioW)
SAUKSAI3T3_1017980(bioW)
SAUQSAI4T8_1017990(bioW)
SAUVSAI7S6_1017980(bioW)
SAUWSAI5S5_1017920(bioW)
SAUXSAI6T6_1017920(bioW)
SAUYSAI8T7_1017960(bioW)
SAUFX998_2409
SABSAB2304c
SUYSA2981_2360
SAUBC248_2471
SAUMBN843_24650
SAUCCA347_2503
SAURSABB_02993(bioW)
SAUIAZ30_12740
SAUDCH52_06865
SAMSNI36_12020
SUHSAMSHR1132_22520
SERSERP2393(bioW)
SEPSE_0182
SEPPSEB_00113
SEPSDP17_1279
SSDSPSINT_2336
SDTSPSE_0126(bioW)
SDPNCTC12225_00148(bioW)
SHUSHYC_01065(bioW)
SSCHLH95_00995
SSCZRN70_01215
SAGQEP23_09060
SPETCEP67_07590
SLZB5P37_05420
SFQC7J90_03530
SCHRDWB92_00920
SSHNCTC13712_02374(bioW)
SSACI6I31_04040
SRAILN051_00710
SCAQQMO72_12700
SROTML435_11650
SGAIK3U27_11660
SFFFOB90_06765
ANXACH33_05725
ASOCCB4_02730(bioW)
ATHEK3F53_13175
AUDPO771_10355(bioW)
ANEUPP175_00220(bioW)
TUMCBW65_01040
SPAEE2C16_15325(bioW)
SURLBI350_03175
FPENKIW23_04250
CACECACET_c13450(bioW)
CFMBJL90_12075
DORDesor_2670
DKUDesku_2247
TFRBR63_04280
CTHMCFE_1510
RTORTO_04560
PBIFKXZ80_10540
PSORRSJ16_12320
RHOMFRIFI_1195
TMYTEMA_34050(bioW)
TKITKV_c07350(bioW)
NCJMCACP_13450(bioW)
HALSD7D81_09505
IFNGM661_06630
PHARNCTC13077_01223(bioW)
PGKM9426_07060
CADCuri_c25540(bioW)
VPRVpar_1006
VATB7L28_04875
VRM44547418_01018(bioW)
VDNNCTC11831_00891(bioW)
VNKVEIT17_08280(bioW)
VRGOKW85_04430
VORVEIS_07530(bioW)
DHODia5BBH33_18170(bioW)
SSGSelsp_0126
SRISELR_03060(bioWF)
MHGMHY_24740
MFUNGXM21_08830
SGBIP3F81_00085
PUFUFO1_4053
PFTJBW_00789 JBW_04119
STEDSPTER_12670(bioW)
SSPHSPSPH_013050(bioW)
SOVASOV_12430(bioW)
SSIDSPSIL_017850(bioW)
SCAOSCACP_11870(bioW)
PFACPFJ30894_02090(bioW)
CDIDIP1381
CDPCD241_1323
CDHCDB402_1292
CDTCDHC01_1323
CDECDHC02_1282
CDRCDHC03_1302
CDACDHC04_1303
CDZCD31A_1398
CDBCDBH8_1375
CDSCDC7B_1385
CDDCDCE8392_1298
CDWCDPW8_1371
CDVCDVA01_1266
CDIPERS451417_01397(bioW)
CKPckrop_1506(bioWF)
CPUCPFRC_05945
CPLCp3995_1206(bioW)
CPGCP316_06095
CPPCpP54B96_1201(bioW)
CPKCP1002_07200
CPQCPC231_05950
CPXCPI19_05570
CPZCpPAT10_1177(bioW)
CORCp267_1234(bioW)
COPCP31_06325
CODCp106_1161(bioW)
COSCp4202_1171(bioW)
COICPCIP5297_06110
COECP258_06110
COUCP162_05185
CPSECPTA_01755
CPSUCPTB_02008
CPSFCPTC_01746
CULCULC22_01291(bioW)
CUCCULC809_01277(bioW)
CUECULC0102_1406(bioW)
CUNCul210932_1345(bioW)
CUQCul210931_1242(bioW)
CUZCul05146_1318(bioW)
CUJCUL131002_1273(bioW)
CUSCulFRC11_1258(bioW)
CVTB843_06145
CIICIMIT_09415
CUVCUREI_07155
COADR71_1458(bioF)
CEICEPID_09085
CLWCLAC_02085
CSPWM42_2495
CPHOCPHO_10675
CSTRCBE89_06150
CSPHCSPHI_02660
CMINNCTC10288_01030(bioW)
CPEGCPELA_04945(bioW)
CGKCGERO_06225(bioW)
CRFFRC0190_01412
CPSOCPPEL_05150(bioW)
CKFI6I12_05810
CPRPI6I69_10265
CAMCI6I65_09405
CGLUI6J20_04705
CSILCBE74_06945
CKWCKALI_03420(bioW)
CORYFQV43_04060
CMFGWO64_003750
CWKIA203_07480
CACCCACC_08710(bioW)
CHINJ5O04_10425
CPSPL9H27_04605
CMASCMASS_00810(bioW)
CIHUCIHUM_06695(bioW)
CHADCHAD_09610(bioW)
CFOUCFOUR_06755(bioW)
CFEUCFELI_06080(bioW)
CAFECAFEL_06640(bioW)
CGOICGOTT_09260(bioW)
CPYRCYJ47_07350
CIKH0194_06345
CBELABMV07_07760
PACPPA1866
PAKHMPREF0675_4919
PAVTIA2EST22_09135
PAXTIA2EST36_09115
PAZTIA2EST2_09075
PAWPAZ_c19410(bioF)
PADTIIST44_02135
PCNTIB1ST10_09540
PACCPAC1_09540
PACHPAGK_1785
PACNTIA1EST1_09165
CACNRN83_09625
PRAPALO_01675
PRLBCB70_09080
CGRN4412665_00276(bioW)
MJAMJ_1297
MVUMetvu_0266
MFSMFS40622_0356
MIFMetin_0084
MJHJH146_0329
MESGMLAUSG7_1138(bioW)
MESAMLASG1_0637(bioW)
MIGMetig_1269
MMPMMP1575(bioW)
MMQMmarC5_0001
MMXMmarC6_1095
MMZMmarC7_0822
MMDGYY_08730
MMAKMMKA1_18050(bioW)
MMAOMMOS7_16870(bioW)
MMADMMJJ_12610(bioW)
MAEMaeo_1420
MVNMevan_0887
MVOMvol_1143
MOKMetok_1553
METFCFE53_06525
MRUmru_2041(bioW)
MOLYLM1_1481
 » show all
Reference
1  [PMID:4623286]
  Authors
Izumi Y, Morita H, Sato K, Tani Y, Ogata K.
  Title
Synthesis of biotin-vitamers from pimelic acid and coenzyme A by cell-free extracts of various bacteria.
  Journal
Biochim Biophys Acta 264:210-3 (1972)
DOI:10.1016/0304-4165(72)90133-X
Reference
2
  Authors
Izumi Y, Morita H, Tani Y, Ogata K.
  Title
The pimelyl-CoA synthetase responsible for the first step in biotin biosynthesis by microorganisms.
  Journal
Agric Biol Chem 38:2257-2262 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.14
IUBMB Enzyme Nomenclature: 6.2.1.14
ExPASy - ENZYME nomenclature database: 6.2.1.14
BRENDA, the Enzyme Database: 6.2.1.14
CAS: 55467-50-0
LinkDB

KEGG   REACTION: R03209
Entry
R03209                      Reaction                               
Name
6-carboxyhyxanoate:CoA ligase (AMP-forming)
Definition
ATP + Pimelate + CoA <=> AMP + Diphosphate + Pimeloyl-CoA
Equation
Reaction class
RC00004  C00010_C01063
RC00014  C01063_C02656
Enzyme
Pathway
rn00780  Biotin metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00577  Biotin biosynthesis, BioW pathway, pimelate => pimeloyl-CoA => biotin
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.14
     R03209  ATP + Pimelate + CoA <=> AMP + Diphosphate + Pimeloyl-CoA
Orthology
K01906  6-carboxyhexanoate--CoA ligase [EC:6.2.1.14]
Other DBs
RHEA: 14784
LinkDB

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