KEGG   ORTHOLOGY: K01906
Entry
K01906                      KO                                     

Name
bioW
Definition
6-carboxyhexanoate--CoA ligase [EC:6.2.1.14]
Pathway
ko00780  Biotin metabolism
ko01100  Metabolic pathways
ko01240  Biosynthesis of cofactors
Module
M00577  Biotin biosynthesis, BioW pathway, pimelate => pimeloyl-CoA => biotin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00780 Biotin metabolism
    K01906  bioW; 6-carboxyhexanoate--CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.14  6-carboxyhexanoate---CoA ligase
     K01906  bioW; 6-carboxyhexanoate--CoA ligase
Other DBs
RN: R03209
COG: COG1424
GO: 0042410
Genes
PCA: Pcar_1666(bioW)
PACE: A6070_06910
PEF: A7E78_02755
DES: DSOUD_1422
DEU: DBW_2418(bioW)
DDS: Ddes_0424
DFI: AXF13_07405
MALU: KU6B_03740
BSU: BSU30240(bioW)
BSR: I33_3078(bioW)
BSL: A7A1_1652
BSH: BSU6051_30240(bioW)
BSY: I653_14475
BSUT: BSUB_03213(bioW)
BSUL: BSUA_03213(bioW)
BSUS: Q433_16400
BSO: BSNT_09444
BSN: BSn5_05960
BSQ: B657_30240(bioW)
BSX: C663_2869(bioW)
BSP: U712_15010
BSS: BSUW23_14650(bioW)
BST: GYO_3272(bioW)
BLI: BL02411(bioW)
BLD: BLi00766(bioW)
BLH: BaLi_c08640(bioW)
BAY: RBAM_018290
BYA: BANAU_1954(bioW)
BAMP: B938_09460
BAML: BAM5036_1766(bioW)
BAMA: RBAU_1804(bioW)
BAMN: BASU_1784(bioW)
BAMB: BAPNAU_1915(bioW)
BAMT: AJ82_10390
BAMY: V529_17990(bioW)
BMP: NG74_01905(bioW)
BAO: BAMF_1924(bioW)
BAZ: BAMTA208_07885(bioW)
BQL: LL3_02014(bioW)
BXH: BAXH7_01606(bioW)
BQY: MUS_2183(bioW)
BAMI: KSO_010220
BAMC: U471_18840
BAMF: U722_09675
BSIA: CWD84_11850
BAE: BATR1942_12910
BVM: B9C48_09335
BSON: S101395_00961(bioW)
BHT: DIC78_16480(bioW)
BJS: MY9_3024
BACP: SB24_00510
BACB: OY17_12280
BACO: OXB_3347
BACY: QF06_13310
BACL: BS34A_32880(bioW)
BALM: BsLM_3008
BGY: BGLY_0780
BACS: AUL54_01440
BIT: BIS30_04490
BACQ: DOE78_13830(bioW)
BEO: BEH_11230
BFX: BC359_10250
BPF: BpOF4_16065(bioW)
BKW: BkAM31D_02740(bioW)
BGI: BGM20_09070
LGY: T479_02545
VPN: A21D_01033(bioW)
APAK: AP3564_14135
PASA: BAOM_1991
SAU: SA2211
SAV: SAV2423
SAW: SAHV_2407
SAH: SaurJH1_2497
SAJ: SaurJH9_2449
SAM: MW2346
SAS: SAS2314
SAR: SAR2513
SAC: SACOL2424(bioW)
SAX: USA300HOU_2407(bioW)
SAA: SAUSA300_2369
SAO: SAOUHSC_02712
SAE: NWMN_2322(bioW)
SAD: SAAV_2489(bioW)
SUU: M013TW_2385
SUV: SAVC_10990
SUE: SAOV_2472c
SUJ: SAA6159_02324(bioW)
SUC: ECTR2_2282
SUT: SAT0131_02618
SUQ: HMPREF0772_10764
SUZ: MS7_2438
SUD: ST398NM01_2476
SUX: SAEMRSA15_23220
SUW: SATW20_25530
SUG: SAPIG2476
SUF: SARLGA251_22050
SAUA: SAAG_00250
SAUE: RSAU_002262(bioW)
SAUN: SAKOR_02404
SAUS: SA40_2173
SAUU: SA957_2257
SAUG: SA268_2330
SAUZ: SAZ172_2528
SAUT: SAI1T1_2017980(bioW)
SAUJ: SAI2T2_1017990(bioW)
SAUK: SAI3T3_1017980(bioW)
SAUQ: SAI4T8_1017990(bioW)
SAUV: SAI7S6_1017980(bioW)
SAUW: SAI5S5_1017920(bioW)
SAUX: SAI6T6_1017920(bioW)
SAUY: SAI8T7_1017960(bioW)
SAUF: X998_2409
SAB: SAB2304c
SUY: SA2981_2360
SAUB: C248_2471
SAUM: BN843_24650
SAUC: CA347_2503
SAUR: SABB_02993(bioW)
SAUI: AZ30_12740
SAUD: CH52_06865
SAMS: NI36_12020
SUH: SAMSHR1132_22520
SER: SERP2393(bioW)
SEP: SE0182
SEPP: SEB_00113
SEPS: DP17_1279
SSD: SPSINT_2336
SDT: SPSE_0126(bioW)
SDP: NCTC12225_00148(bioW)
SHU: SHYC_01065(bioW)
SSCH: LH95_00995
SSCZ: RN70_01215
SAGQ: EP23_09060
SPET: CEP67_07590
SLZ: B5P37_05420
SFQ: C7J90_03530
SCHR: DWB92_00920
SSH: NCTC13712_02374(bioW)
SFF: FOB90_06765
ANX: ACH33_05725
ASOC: CB4_02730(bioW)
TUM: CBW65_01040
SPAE: E2C16_15325(bioW)
CACE: CACET_c13450(bioW)
CFM: BJL90_12075
RTO: RTO_04560
PSOR: RSJ16_12320
DKU: Desku_2247
DOR: Desor_2670
TFR: BR63_04280
CTHM: CFE_1510
TKI: TKV_c07350(bioW)
HALS: D7D81_09505
PHAR: NCTC13077_01223(bioW)
CAD: Curi_c25540(bioW)
VPR: Vpar_1006
VAT: B7L28_04875
VRM: 44547418_01018(bioW)
VDN: NCTC11831_00891(bioW)
VNK: VEIT17_08280(bioW)
DHO: Dia5BBH33_18170(bioW)
SSG: Selsp_0126
SRI: SELR_03060(bioWF)
MHG: MHY_24740
MFUN: GXM21_08830
PUF: UFO1_4053
PFT: JBW_00789 JBW_04119
STED: SPTER_12670(bioW)
PFAC: PFJ30894_02090(bioW)
CDI: DIP1381
CDP: CD241_1323
CDH: CDB402_1292
CDT: CDHC01_1323
CDE: CDHC02_1282
CDR: CDHC03_1302
CDA: CDHC04_1303
CDZ: CD31A_1398
CDB: CDBH8_1375
CDS: CDC7B_1385
CDD: CDCE8392_1298
CDW: CDPW8_1371
CDV: CDVA01_1266
CDIP: ERS451417_01397(bioW)
CKP: ckrop_1506(bioWF)
CPL: Cp3995_1206(bioW)
CPG: CP316_06095
CPP: CpP54B96_1201(bioW)
CPK: CP1002_07200
CPQ: CPC231_05950
CPX: CPI19_05570
CPZ: CpPAT10_1177(bioW)
COR: Cp267_1234(bioW)
COP: CP31_06325
COD: Cp106_1161(bioW)
COS: Cp4202_1171(bioW)
COI: CPCIP5297_06110
COE: CP258_06110
COU: CP162_05185
CPSE: CPTA_01755
CPSU: CPTB_02008
CPSF: CPTC_01746
CUL: CULC22_01291(bioW)
CUC: CULC809_01277(bioW)
CUE: CULC0102_1406(bioW)
CUN: Cul210932_1345(bioW)
CUS: CulFRC11_1258(bioW)
CUQ: Cul210931_1242(bioW)
CUZ: Cul05146_1318(bioW)
CUJ: CUL131002_1273(bioW)
CVT: B843_06145
CII: CIMIT_09415
CUV: CUREI_07155
COA: DR71_1458(bioF)
CEI: CEPID_09085
CLW: CLAC_02085
CSP: WM42_2495
CPHO: CPHO_10675
CSTR: CBE89_06150
CSPH: CSPHI_02660
CMIN: NCTC10288_01030(bioW)
CPEG: CPELA_04945(bioW)
CGK: CGERO_06225(bioW)
CRF: FRC0190_01412
CPSO: CPPEL_05150(bioW)
PAC: PPA1866
PAK: HMPREF0675_4919
PAV: TIA2EST22_09135
PAX: TIA2EST36_09115
PAZ: TIA2EST2_09075
PAW: PAZ_c19410(bioF)
PAD: TIIST44_02135
PCN: TIB1ST10_09540
PACC: PAC1_09540
PACH: PAGK_1785
PACN: TIA1EST1_09165
CACN: RN83_09625
PRA: PALO_01675
CGRN: 4412665_00276(bioW)
PRL: BCB70_09080
AAGG: ETAA8_58000
TPI: TREPR_3053(bioW)
FSU: Fisuc_2956
FSC: FSU_0221(bioW)
AAE: aq_1659(bioW)
HYA: HY04AAS1_0813
HHO: HydHO_0808
HYS: HydSN_0825
HTH: HTH_1774(bioW)
HTE: Hydth_1756
TAL: Thal_1538
TRD: THERU_03735
SUL: SYO3AOP1_1703
SAF: SULAZ_1395(bioW)
PMX: PERMA_1854(bioW)
TAM: Theam_0831
DTE: Dester_0730
TYE: THEYE_A0810(bioW)
DTP: JZK55_14060(bioW)
LFC: LFE_0971
LFI: LFML04_1509(bioW)
LFP: Y981_07525
LEG: ABH19_05580
MJA: MJ_1297
MVU: Metvu_0266
MFS: MFS40622_0356
MIF: Metin_0084
MJH: JH146_0329
MIG: Metig_1269
MMP: MMP1575(bioW)
MMQ: MmarC5_0001
MMX: MmarC6_1095
MMZ: MmarC7_0822
MMD: GYY_08730
MMAK: MMKA1_18050(bioW)
MMAO: MMOS7_16870(bioW)
MMAD: MMJJ_12610(bioW)
MAE: Maeo_1420
MVN: Mevan_0887
MVO: Mvol_1143
MOK: Metok_1553
METF: CFE53_06525
MRU: mru_2041(bioW)
MOL: YLM1_1481
 » show all
Reference
PMID:8763940
  Authors
Bower S, Perkins JB, Yocum RR, Howitt CL, Rahaim P, Pero J
  Title
Cloning, sequencing, and characterization of the Bacillus subtilis biotin biosynthetic operon.
  Journal
J Bacteriol 178:4122-30 (1996)
DOI:10.1128/JB.178.14.4122-4130.1996
  Sequence
[bsu:BSU30240]
Reference
PMID:1445232
  Authors
Ploux O, Soularue P, Marquet A, Gloeckler R, Lemoine Y
  Title
Investigation of the first step of biotin biosynthesis in Bacillus sphaericus. Purification and characterization of the pimeloyl-CoA synthase, and uptake of pimelate.
  Journal
Biochem J 287 ( Pt 3):685-90 (1992)
DOI:10.1042/bj2870685
LinkDB

KEGG   ENZYME: 6.2.1.14
Entry
EC 6.2.1.14                 Enzyme                                 

Name
6-carboxyhexanoate---CoA ligase;
6-carboxyhexanoyl-CoA synthetase;
pimelyl-CoA synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
6-carboxyhexanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA [RN:R03209]
Reaction(KEGG)
R03209
Substrate
ATP [CPD:C00002];
6-carboxyhexanoate [CPD:C02656];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
6-carboxyhexanoyl-CoA [CPD:C01063]
History
EC 6.2.1.14 created 1983
Pathway
ec00780  Biotin metabolism
ec01100  Metabolic pathways
Orthology
K01906  6-carboxyhexanoate--CoA ligase
Genes
PCA: Pcar_1666(bioW)
PACE: A6070_06910
PEF: A7E78_02755
DES: DSOUD_1422
DEU: DBW_2418(bioW)
DDS: Ddes_0424
DFI: AXF13_07405
MALU: KU6B_03740
BSU: BSU30240(bioW)
BSR: I33_3078(bioW)
BSL: A7A1_1652
BSH: BSU6051_30240(bioW)
BSY: I653_14475
BSUT: BSUB_03213(bioW)
BSUL: BSUA_03213(bioW)
BSUS: Q433_16400
BSO: BSNT_09444
BSN: BSn5_05960
BSQ: B657_30240(bioW)
BSX: C663_2869(bioW)
BSP: U712_15010
BSS: BSUW23_14650(bioW)
BST: GYO_3272(bioW)
BLI: BL02411(bioW)
BLD: BLi00766(bioW)
BLH: BaLi_c08640(bioW)
BAY: RBAM_018290
BYA: BANAU_1954(bioW)
BAMP: B938_09460
BAML: BAM5036_1766(bioW)
BAMA: RBAU_1804(bioW)
BAMN: BASU_1784(bioW)
BAMB: BAPNAU_1915(bioW)
BAMT: AJ82_10390
BAMY: V529_17990(bioW)
BMP: NG74_01905(bioW)
BAO: BAMF_1924(bioW)
BAZ: BAMTA208_07885(bioW)
BQL: LL3_02014(bioW)
BXH: BAXH7_01606(bioW)
BQY: MUS_2183(bioW)
BAMI: KSO_010220
BAMC: U471_18840
BAMF: U722_09675
BSIA: CWD84_11850
BAE: BATR1942_12910
BVM: B9C48_09335
BSON: S101395_00961(bioW)
BHT: DIC78_16480(bioW)
BJS: MY9_3024
BACP: SB24_00510
BACB: OY17_12280
BACO: OXB_3347
BACY: QF06_13310
BACL: BS34A_32880(bioW)
BALM: BsLM_3008
BGY: BGLY_0780
BACS: AUL54_01440
BIT: BIS30_04490
BACQ: DOE78_13830(bioW)
BEO: BEH_11230
BFX: BC359_10250
BPF: BpOF4_16065(bioW)
BKW: BkAM31D_02740(bioW)
BGI: BGM20_09070
LGY: T479_02545
VPN: A21D_01033(bioW)
APAK: AP3564_14135
PASA: BAOM_1991
SAU: SA2211
SAV: SAV2423
SAW: SAHV_2407
SAH: SaurJH1_2497
SAJ: SaurJH9_2449
SAM: MW2346
SAS: SAS2314
SAR: SAR2513
SAC: SACOL2424(bioW)
SAX: USA300HOU_2407(bioW)
SAA: SAUSA300_2369
SAO: SAOUHSC_02712
SAE: NWMN_2322(bioW)
SAD: SAAV_2489(bioW)
SUU: M013TW_2385
SUV: SAVC_10990
SUE: SAOV_2472c
SUJ: SAA6159_02324(bioW)
SUC: ECTR2_2282
SUT: SAT0131_02618
SUQ: HMPREF0772_10764
SUZ: MS7_2438
SUD: ST398NM01_2476
SUX: SAEMRSA15_23220
SUW: SATW20_25530
SUG: SAPIG2476
SUF: SARLGA251_22050
SAUA: SAAG_00250
SAUE: RSAU_002262(bioW)
SAUN: SAKOR_02404
SAUS: SA40_2173
SAUU: SA957_2257
SAUG: SA268_2330
SAUZ: SAZ172_2528
SAUT: SAI1T1_2017980(bioW)
SAUJ: SAI2T2_1017990(bioW)
SAUK: SAI3T3_1017980(bioW)
SAUQ: SAI4T8_1017990(bioW)
SAUV: SAI7S6_1017980(bioW)
SAUW: SAI5S5_1017920(bioW)
SAUX: SAI6T6_1017920(bioW)
SAUY: SAI8T7_1017960(bioW)
SAUF: X998_2409
SAB: SAB2304c
SUY: SA2981_2360
SAUB: C248_2471
SAUM: BN843_24650
SAUC: CA347_2503
SAUR: SABB_02993(bioW)
SAUI: AZ30_12740
SAUD: CH52_06865
SAMS: NI36_12020
SUH: SAMSHR1132_22520
SER: SERP2393(bioW)
SEP: SE0182
SEPP: SEB_00113
SEPS: DP17_1279
SSD: SPSINT_2336
SDT: SPSE_0126(bioW)
SDP: NCTC12225_00148(bioW)
SHU: SHYC_01065(bioW)
SSCH: LH95_00995
SSCZ: RN70_01215
SAGQ: EP23_09060
SPET: CEP67_07590
SLZ: B5P37_05420
SFQ: C7J90_03530
SCHR: DWB92_00920
SSH: NCTC13712_02374(bioW)
SFF: FOB90_06765
ANX: ACH33_05725
ASOC: CB4_02730(bioW)
TUM: CBW65_01040
SPAE: E2C16_15325(bioW)
CACE: CACET_c13450(bioW)
CFM: BJL90_12075
RTO: RTO_04560
PSOR: RSJ16_12320
DKU: Desku_2247
DOR: Desor_2670
TFR: BR63_04280
CTHM: CFE_1510
TKI: TKV_c07350(bioW)
HALS: D7D81_09505
PHAR: NCTC13077_01223(bioW)
CAD: Curi_c25540(bioW)
VPR: Vpar_1006
VAT: B7L28_04875
VRM: 44547418_01018(bioW)
VDN: NCTC11831_00891(bioW)
VNK: VEIT17_08280(bioW)
DHO: Dia5BBH33_18170(bioW)
SSG: Selsp_0126
SRI: SELR_03060(bioWF)
MHG: MHY_24740
MFUN: GXM21_08830
PUF: UFO1_4053
PFT: JBW_00789 JBW_04119
STED: SPTER_12670(bioW)
PFAC: PFJ30894_02090(bioW)
CDI: DIP1381
CDP: CD241_1323
CDH: CDB402_1292
CDT: CDHC01_1323
CDE: CDHC02_1282
CDR: CDHC03_1302
CDA: CDHC04_1303
CDZ: CD31A_1398
CDB: CDBH8_1375
CDS: CDC7B_1385
CDD: CDCE8392_1298
CDW: CDPW8_1371
CDV: CDVA01_1266
CDIP: ERS451417_01397(bioW)
CKP: ckrop_1506(bioWF)
CPL: Cp3995_1206(bioW)
CPG: CP316_06095
CPP: CpP54B96_1201(bioW)
CPK: CP1002_07200
CPQ: CPC231_05950
CPX: CPI19_05570
CPZ: CpPAT10_1177(bioW)
COR: Cp267_1234(bioW)
COP: CP31_06325
COD: Cp106_1161(bioW)
COS: Cp4202_1171(bioW)
COI: CPCIP5297_06110
COE: CP258_06110
COU: CP162_05185
CPSE: CPTA_01755
CPSU: CPTB_02008
CPSF: CPTC_01746
CUL: CULC22_01291(bioW)
CUC: CULC809_01277(bioW)
CUE: CULC0102_1406(bioW)
CUN: Cul210932_1345(bioW)
CUS: CulFRC11_1258(bioW)
CUQ: Cul210931_1242(bioW)
CUZ: Cul05146_1318(bioW)
CUJ: CUL131002_1273(bioW)
CVT: B843_06145
CII: CIMIT_09415
CUV: CUREI_07155
COA: DR71_1458(bioF)
CEI: CEPID_09085
CLW: CLAC_02085
CSP: WM42_2495
CPHO: CPHO_10675
CSTR: CBE89_06150
CSPH: CSPHI_02660
CMIN: NCTC10288_01030(bioW)
CPEG: CPELA_04945(bioW)
CGK: CGERO_06225(bioW)
CRF: FRC0190_01412
CPSO: CPPEL_05150(bioW)
PAC: PPA1866
PAK: HMPREF0675_4919
PAV: TIA2EST22_09135
PAX: TIA2EST36_09115
PAZ: TIA2EST2_09075
PAW: PAZ_c19410(bioF)
PAD: TIIST44_02135
PCN: TIB1ST10_09540
PACC: PAC1_09540
PACH: PAGK_1785
PACN: TIA1EST1_09165
CACN: RN83_09625
PRA: PALO_01675
CGRN: 4412665_00276(bioW)
PRL: BCB70_09080
AAGG: ETAA8_58000
TPI: TREPR_3053(bioW)
FSU: Fisuc_2956
FSC: FSU_0221(bioW)
AAE: aq_1659(bioW)
HYA: HY04AAS1_0813
HHO: HydHO_0808
HYS: HydSN_0825
HTH: HTH_1774(bioW)
HTE: Hydth_1756
TAL: Thal_1538
TRD: THERU_03735
SUL: SYO3AOP1_1703
SAF: SULAZ_1395(bioW)
PMX: PERMA_1854(bioW)
TAM: Theam_0831
DTE: Dester_0730
TYE: THEYE_A0810(bioW)
DTP: JZK55_14060(bioW)
LFC: LFE_0971
LFI: LFML04_1509(bioW)
LFP: Y981_07525
LEG: ABH19_05580
MJA: MJ_1297
MVU: Metvu_0266
MFS: MFS40622_0356
MIF: Metin_0084
MJH: JH146_0329
MIG: Metig_1269
MMP: MMP1575(bioW)
MMQ: MmarC5_0001
MMX: MmarC6_1095
MMZ: MmarC7_0822
MMD: GYY_08730
MMAK: MMKA1_18050(bioW)
MMAO: MMOS7_16870(bioW)
MMAD: MMJJ_12610(bioW)
MAE: Maeo_1420
MVN: Mevan_0887
MVO: Mvol_1143
MOK: Metok_1553
METF: CFE53_06525
MRU: mru_2041(bioW)
MOL: YLM1_1481
 » show all
Reference
1  [PMID:4623286]
  Authors
Izumi Y, Morita H, Sato K, Tani Y, Ogata K.
  Title
Synthesis of biotin-vitamers from pimelic acid and coenzyme A by cell-free extracts of various bacteria.
  Journal
Biochim Biophys Acta 264:210-3 (1972)
DOI:10.1016/0304-4165(72)90133-X
Reference
2
  Authors
Izumi, Y., Morita, H., Tani, Y. and Ogata, K.
  Title
The pimelyl-CoA synthetase responsible for the first step in biotin biosynthesis by microorganisms.
  Journal
Agric Biol Chem 38:2257-2262 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.14
IUBMB Enzyme Nomenclature: 6.2.1.14
ExPASy - ENZYME nomenclature database: 6.2.1.14
BRENDA, the Enzyme Database: 6.2.1.14
CAS: 55467-50-0
LinkDB

KEGG   REACTION: R03209
Entry
R03209                      Reaction                               

Name
6-Carboxyhyxanoate:CoA ligase (AMP-forming)
Definition
ATP + Pimelate + CoA <=> AMP + Diphosphate + 6-Carboxyhexanoyl-CoA
Equation
Reaction class
RC00004  C00010_C01063
RC00014  C01063_C02656
Enzyme
Pathway
rn00780  Biotin metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00577  Biotin biosynthesis, BioW pathway, pimelate => pimeloyl-CoA => biotin
Orthology
K01906  6-carboxyhexanoate--CoA ligase [EC:6.2.1.14]
Other DBs
RHEA: 14784
LinkDB

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