KEGG   ORTHOLOGY: K04671
Entry
K04671                      KO                                     

Name
BMPR2
Definition
bone morphogenetic protein receptor type-2 [EC:2.7.11.30]
Pathway
ko04060  Cytokine-cytokine receptor interaction
ko04350  TGF-beta signaling pathway
ko04360  Axon guidance
ko04390  Hippo signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko05206  MicroRNAs in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H01619  Primary pulmonary hypertension
H01621  Pulmonary arterial hypertension
H01866  Pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K04671  BMPR2; bone morphogenetic protein receptor type-2
   04390 Hippo signaling pathway
    K04671  BMPR2; bone morphogenetic protein receptor type-2
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04671  BMPR2; bone morphogenetic protein receptor type-2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04671  BMPR2; bone morphogenetic protein receptor type-2
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K04671  BMPR2; bone morphogenetic protein receptor type-2
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K04671  BMPR2; bone morphogenetic protein receptor type-2
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04671  BMPR2; bone morphogenetic protein receptor type-2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04671  BMPR2; bone morphogenetic protein receptor type-2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04671  BMPR2; bone morphogenetic protein receptor type-2
Protein kinases [BR:ko01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR2 family [OT]
   K04671  BMPR2; bone morphogenetic protein receptor type-2
Other DBs
GO: 0016362
Genes
HSA: 659(BMPR2)
PTR: 459885(BMPR2)
PPS: 100987362(BMPR2)
GGO: 101152104(BMPR2)
PON: 100441517(BMPR2)
NLE: 100599616(BMPR2)
MCC: 704088(BMPR2)
MCF: 102132657(BMPR2)
CSAB: 103217668(BMPR2)
RRO: 104680809(BMPR2)
RBB: 108537211(BMPR2)
CJC: 100402963(BMPR2)
SBQ: 101047869(BMPR2)
MMU: 12168(Bmpr2)
MCAL: 110291041(Bmpr2)
MPAH: 110321925(Bmpr2)
RNO: 140590(Bmpr2)
MUN: 110559103(Bmpr2)
CGE: 100764519(Bmpr2)
NGI: 103736034(Bmpr2)
HGL: 101701138(Bmpr2)
CCAN: 109683698(Bmpr2)
OCU: 100350246(BMPR2)
TUP: 102472860(BMPR2)
CFA: 478875(BMPR2)
VVP: 112922861(BMPR2)
AML: 100483427(BMPR2)
UMR: 103659757(BMPR2)
UAH: 113250576(BMPR2)
ORO: 101386632(BMPR2)
ELK: 111141287
FCA: 101096338(BMPR2)
PTG: 102972964(BMPR2)
PPAD: 109259182(BMPR2)
AJU: 106978276(BMPR2)
BTA: 407127(BMPR2)
BOM: 102276585(BMPR2)
BIU: 109575608(BMPR2)
BBUB: 102393717(BMPR2)
CHX: 102173240(BMPR2)
OAS: 101103793(BMPR2)
SSC: 100127483(BMPR2)
CFR: 102504117(BMPR2)
CDK: 105098972(BMPR2)
BACU: 103010629(BMPR2)
LVE: 103089843(BMPR2)
OOR: 101276638(BMPR2)
DLE: 111171741(BMPR2)
PCAD: 102993283(BMPR2)
ECB: 100067195(BMPR2)
EPZ: 103549220(BMPR2)
EAI: 106824062(BMPR2)
MYB: 102255023(BMPR2)
MYD: 102769364(BMPR2)
MNA: 107533955(BMPR2)
HAI: 109379244(BMPR2)
DRO: 112307666(BMPR2)
PALE: 102882003(BMPR2)
RAY: 107519367(BMPR2)
MJV: 108384194(BMPR2)
LAV: 100661600(BMPR2)
TMU: 101348356
MDO: 100018765(BMPR2)
SHR: 100925781(BMPR2)
PCW: 110198506(BMPR2)
OAA: 100077247(BMPR2)
GGA: 374147(BMPR2)
MGP: 100551416(BMPR2)
CJO: 107316544(BMPR2)
NMEL: 110400080(BMPR2)
APLA: 101793707(BMPR2)
ACYG: 106030098(BMPR2)
TGU: 100227149(BMPR2)
LSR: 110484595(BMPR2)
SCAN: 103814497(BMPR2)
GFR: 102043611(BMPR2)
FAB: 101806244(BMPR2)
PHI: 102110191(BMPR2)
PMAJ: 107207396(BMPR2)
CCAE: 111931997(BMPR2)
CCW: 104693787(BMPR2)
ETL: 114055729(BMPR2)
FPG: 101919199(BMPR2)
FCH: 102046415(BMPR2)
CLV: 102086688(BMPR2)
EGZ: 104130476(BMPR2)
NNI: 104010202(BMPR2)
ACUN: 113482567(BMPR2)
PADL: 103923542(BMPR2)
AAM: 106492422(BMPR2)
ASN: 102370042(BMPR2)
AMJ: 102577319(BMPR2)
PSS: 102456232(BMPR2)
CMY: 102929585(BMPR2)
CPIC: 101951829(BMPR2)
ACS: 100553521(bmpr2)
PVT: 110088189(BMPR2)
PBI: 103060123(BMPR2)
PMUR: 107290699(BMPR2)
PMUA: 114581483(BMPR2)
GJA: 107113314(BMPR2)
XLA: 108701455(bmpr2.L) 397981(bmpr2.S)
XTR: 100494339(bmpr2)
NPR: 108785044(BMPR2)
DRE: 555655(bmpr2b) 562822(bmpr2a)
CCAR: 109086023
IPU: 108266402(bmpr2) 108272897(BMPR2)
PHYP: 113525969(bmpr2) 113538343
AMEX: 103041475 103046530(bmpr2)
EEE: 113578552(bmpr2) 113582596
TRU: 101069366(bmpr2)
LCO: 104926387(bmpr2) 104931750
NCC: 104958413(bmpr2)
MZE: 101480484 101485979(bmpr2)
ONL: 100690976(bmpr2) 100694986
OLA: 101167856(bmpr2)
XMA: 102230588 102232740(bmpr2)
XCO: 114140973(bmpr2) 114148757
PRET: 103461763 103474116(bmpr2)
CVG: 107087239(bmpr2) 107103972
NFU: 107377073(bmpr2)
KMR: 108242164(bmpr2) 108247756
AOCE: 111565854(bmpr2) 111567532
CSEM: 103386397(amhr2) 103389452(bmpr2)
POV: 109646787
SDU: 111222709(bmpr2)
SLAL: 111655508 111672388(bmpr2)
HCQ: 109507796(bmpr2)
BPEC: 110153178(bmpr2)
MALB: 109951513(bmpr2) 109970434
SFM: 108920640 108942470(bmpr2)
PKI: 111840727 111858338(bmpr2)
LCM: 102353534(BMPR2)
CMK: 103189999(bmpr2)
RTP: 109916147
BFO: 118403893
SPU: 586095
APLC: 110978100
SKO: 102810094
DME: Dmel_CG10776(wit)
DER: 6543570
DSE: 6610709
DSI: Dsimw501_GD13298(Dsim_GD13298)
DAN: 6507042
DSR: 110178671
DPE: 6603298
DMN: 108152977
DWI: 6645983
DAZ: 108613396
DNV: 108651397
DHE: 111597498
DVI: 6623303
MDE: 101888345
LCQ: 111683314
AAG: 110676109
AME: 413895
BIM: 100743451
BTER: 100647132
CCAL: 108630382
OBB: 114871761
SOC: 105205018
MPHA: 105830272
AEC: 105154345
ACEP: 105618737
PBAR: 105429516
VEM: 105566244
HST: 105189198
DQU: 106746512
CFO: 105259096
LHU: 105676358
PGC: 109859096
OBO: 105283395
PCF: 106792638
NVI: 100121252
CSOL: 105367910
TCA: 663692(wit)
DPA: 109536255
ATD: 109599519
NVL: 108563153
BMOR: 101744534
BMAN: 114241953
PMAC: 106715185
PRAP: 110997216
HAW: 110369600
TNL: 113504137
PXY: 105381315
BTAB: 109033729
CLEC: 106664345
ZNE: 110830124
FCD: 110844532
DPTE: 113799434
PCAN: 112556127
MYI: 110442406
OBI: 106882102
LAK: 106170149
NVE: 5513139
EPA: 110238334
AMIL: 114966718
PDAM: 113685711
SPIS: 111320804
HMG: 100199656
 » show all
Reference
PMID:7791754
  Authors
Liu F, Ventura F, Doody J, Massague J.
  Title
Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.
  Journal
Mol Cell Biol 15:3479-86 (1995)
DOI:10.1128/MCB.15.7.3479
  Sequence
[hsa:659]
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