KEGG ORTHOLOGY: K07508

ORTHOLOGY: K07508

Entry

K07508                      KO

Symbol

ACAA2

Name

acetyl-CoA acyltransferase 2 [EC:2.3.1.16]

Pathway

map00062

Fatty acid elongation

map00071

Fatty acid degradation

map00280

Valine, leucine and isoleucine degradation

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01212

Fatty acid metabolism

Module

M00085

Fatty acid elongation in mitochondria

M00087

beta-Oxidation

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K07508  ACAA2; acetyl-CoA acyltransferase 2
   00071 Fatty acid degradation
    K07508  ACAA2; acetyl-CoA acyltransferase 2
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K07508  ACAA2; acetyl-CoA acyltransferase 2
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.16  acetyl-CoA C-acyltransferase
     K07508  ACAA2; acetyl-CoA acyltransferase 2

Other DBs

RN:	R00238 R00391 R00927 R01177 R03778 R03858 R03991 R04546 R04742 R04747

GO:

0003988

Genes

HSA:	10449(ACAA2)

PTR:	455414(ACAA2)

PPS:	100986504(ACAA2)

GGO:	101146857(ACAA2)

PON:	100171644(ACAA2)

NLE:	100595632(ACAA2)

MCC:	709350(ACAA2)

MCF:	101865671(ACAA2)

CSAB:

103222430(ACAA2)

CATY:

105592504(ACAA2)

PANU:

101012951(ACAA2)

TGE:	112611277(ACAA2)

RRO:	104656838(ACAA2)

RBB:	108539750(ACAA2)

TFN:	117063912(ACAA2) 117083992

PTEH:

111539668(ACAA2)

CJC:	100402284(ACAA2)

SBQ:	101036389(ACAA2)

CSYR:

103266899(ACAA2)

MMUR:

105874245(ACAA2)

OGA:	100958557(ACAA2)

MMU:	52538(Acaa2)

MCAL:

110284792(Acaa2)

MPAH:

110333199(Acaa2)

RNO:	170465(Acaa2)

MCOC:

116087353(Acaa2)

MUN:	110561488(Acaa2)

CGE:	100765829(Acaa2)

PLEU:

114694872(Acaa2)

NGI:	103724572(Acaa2)

HGL:	101721744(Acaa2)

CPOC:

100715434(Acaa2)

CCAN:

109698177(Acaa2)

DORD:

105987579(Acaa2)

DSP:	122104322(Acaa2)

NCAR:

124965793

OCU:	100339733(ACAA2)

OPI:	101529594(ACAA2)

TUP:	102473069(ACAA2)

CFA:	490568(ACAA2)

VVP:	112925318(ACAA2)

VLG:	121489297(ACAA2)

AML:	100476344(ACAA2)

UMR:	103664100(ACAA2)

UAH:	113253408(ACAA2)

UAR:	123787380(ACAA2)

ELK:

111142457

LLV:

125081701

MPUF:

101687319(ACAA2)

ORO:	101378384(ACAA2)

EJU:	114205018(ACAA2)

ZCA:	113913091(ACAA2)

MLX:	118004702(ACAA2)

FCA:	101089302(ACAA2) 111559111

PYU:	121032937(ACAA2)

PBG:	122470761(ACAA2)

PTG:	102967396(ACAA2)

PPAD:

109275723(ACAA2)

AJU:	106974956(ACAA2)

HHV:	120229676(ACAA2)

BTA:	522006(ACAA2)

BOM:	102270140(ACAA2)

BBUB:

102391006(ACAA2)

CHX:	102183474(ACAA2)

OAS:	101111925(ACAA2)

ODA:	120880995(ACAA2)

CCAD:

122425461(ACAA2)

SSC:	100312959(ACAA2)

CFR:	102510739(ACAA2)

CBAI:

105073958(ACAA2)

CDK:	105103279(ACAA2)

VPC:	102536826(ACAA2)

BACU:

103010085(ACAA2)

LVE:	103089821(ACAA2)

OOR:	101280546(ACAA2)

DLE:	111180263(ACAA2)

PCAD:

102982675(ACAA2)

PSIU:

116739273(ACAA2)

ECB:	100069345(ACAA2)

EPZ:	103547459(ACAA2)

EAI:	106834604(ACAA2)

MYB:	102258815(ACAA2)

MYD:	102756865(ACAA2)

MMYO:

118663396(ACAA2)

MLF:	102423649(ACAA2)

MNA:	107546630(ACAA2)

PKL:	118708032(ACAA2)

HAI:	109376904(ACAA2)

DRO:	112322907(ACAA2)

SHON:

118978584(ACAA2)

AJM:	119063650(ACAA2)

PDIC:

114506451(ACAA2)

PHAS:

123826347(ACAA2)

MMF:	118619001(ACAA2)

RFQ:	117011944(ACAA2)

PALE:

102895865(ACAA2)

PGIG:

120585516(ACAA2)

PVP:	105292509(ACAA2)

MJV:	108400223(ACAA2)

TOD:	119243044(ACAA2)

SARA:

101550180(ACAA2)

LAV:	100669834(ACAA2)

DNM:	101414975(ACAA2)

MDO:	100020101(ACAA2)

GAS:	123252209(ACAA2)

SHR:	100919041(ACAA2)

PCW:	110198152(ACAA2)

OAA:	100077748(ACAA2)

GGA:	426847(ACAA2)

PCOC:

116231380(ACAA2)

MGP:	100543276(ACAA2)

CJO:	107305710(ACAA2)

NMEL:

110390054(ACAA2)

APLA:

101791052(ACAA2)

ACYG:

106037343(ACAA2)

AFUL:

116500921(ACAA2)

TGU:	100231849(ACAA2)

LSR:	110478717(ACAA2)

SCAN:

103820669(ACAA2)

PMOA:

120513688(ACAA2)

OTC:	121346103(ACAA2)

PRUF:

121350379(ACAA2)

GFR:	102031671(ACAA2)

FAB:	101820899(ACAA2)

PHI:	102099098(ACAA2)

PMAJ:

107198381(ACAA2)

CCAE:

111940954(ACAA2)

CCW:	104686724(ACAA2)

ETL:	114064115(ACAA2)

ZAB:	102063959(ACAA2)

FPG:	101917832(ACAA2)

FCH:	102058082(ACAA2)

CLV:	102090854(ACAA2)

EGZ:	104134191(ACAA2)

NNI:	104010858(ACAA2)

ACUN:

113489837(ACAA2)

TALA:

104357364(ACAA2)

PADL:

103919461(ACAA2)

ACHC:

115337441(ACAA2)

AAM:	106487890(ACAA2)

AROW:

112978618(ACAA2)

NPD:	112947775(ACAA2)

DNE:	112994469(ACAA2)

ASN:	102376718(ACAA2)

AMJ:	102568981(ACAA2)

CPOO:

109307727(ACAA2)

GGN:	109298024(ACAA2)

PSS:	102446655(ACAA2)

CMY:	102938453(ACAA2)

CPIC:

101948785(ACAA2)

TST:	117879173(ACAA2)

CABI:

116817764(ACAA2)

MRV:	120407484(ACAA2)

ACS:	100554020(acaa2)

PVT:	110090044(ACAA2)

SUND:

121922842(ACAA2)

PBI:	103049409(ACAA2)

PMUR:

107284131(ACAA2)

TSR:	106545855(ACAA2)

PGUT:

117654831(ACAA2)

VKO:	123023993(ACAA2)

PMUA:

114606439(ACAA2)

ZVI:	118077071(ACAA2)

GJA:	107109968(ACAA2)

XLA:	108705465(acaa2.S) 380424(acaa2.L)

XTR:	779631(acaa2)

NPR:	108790694(ACAA2)

RTEM:

120926716(ACAA2) 120943975

BBUF:

120992249(ACAA2)

BGAR:

122937233(ACAA2)

DRE:	406325(acaa2)

SRX:	107752996 107754401(acaa2)

SANH:

107671002

SGH:	107559599(acaa2)

CAUA:

113106963(acaa2)

IPU:	100304819(acaa2)

PHYP:

113533324(acaa2)

SMEO:

124400027(acaa2)

TFD:	113658509(acaa2)

AMEX:

103039096(acaa2)

EEE:	113590681(acaa2)

TRU:	101062577(acaa2)

TNG:	GSTEN00029578G001

LCO:	104921655(acaa2)

NCC:	104956691(acaa2)

CGOB:

115013918(acaa2)

ELY:	117252366(acaa2)

PLEP:

121944348(acaa2)

SLUC:

116054451(acaa2)

ECRA:

117945493(acaa2)

PFLV:

114555635(acaa2)

GAT:	120831083(acaa2)

PPUG:

119225245(acaa2)

MSAM:

119891199(acaa2)

CUD:	121510452(acaa2)

MZE:	101475921(acaa2)

ONL:	100699406(acaa2)

OAU:	116311007(acaa2)

OLA:	101171672(acaa2)

OML:	112148074(acaa2)

XMA:	102225065(acaa2)

XCO:	114154595(acaa2)

XHE:	116729793(acaa2)

PRET:

103470032(acaa2)

PFOR:

103145834(acaa2)

PLAI:

106956800(acaa2)

PMEI:

106921746(acaa2)

GAF:	122826529(acaa2)

CVG:	107089652(acaa2)

CTUL:

119778132(acaa2)

GMU:	124877320(acaa2)

NFU:	107394253(acaa2)

KMR:	108233695(acaa2)

NWH:	119413240(acaa2)

AOCE:

111577286(acaa2)

CSEM:

103397146 103397771(acaa2)

POV:	109637054(acaa2)

SSEN:

122769394(acaa2)

HHIP:

117768157(acaa2)

LCF:	108881684(acaa2)

SDU:	111236472(acaa2)

SLAL:

111665974(acaa2)

XGL:	120805072(acaa2)

HCQ:	109527328(acaa2)

BPEC:

110155754(acaa2)

MALB:

109956563(acaa2)

SASA:

106580430(THIM) 106585052(THIM)

OTW:	112248600 112262751(acaa2)

OMY:	110525808 110536192(acaa2)

OGO:	124034212 124035238(acaa2)

ONE:	115111718 115140188

SALP:

111957767 111974321

SNH:	120039009(acaa2) 120054931

ELS:	105014304(acaa2)

SFM:	108920128(acaa2)

PKI:	111854352(acaa2)

AANG:

118237582(acaa2)

LOC:	102693198(acaa2)

PSPA:

121317725(acaa2) 121327200

ARUT:

117409644(acaa2)

LCM:	102358248(ACAA2)

CMK:	103187341(acaa2)

RTP:

BFO:

BBEL:

CIN:

SCLV:

SPU:	115927202 588288

APLC:

110982367

SKO:

100367814

DME:	Dmel_CG4600(yip2)

DER:

6541725

DSE:

6611877

DSI:	Dsimw501_GD23636(Dsim_GD23636)

DYA:	Dyak_GE18877(Dyak_yip2)

DAN:

6498529

DSR:

110183194

DPO:	Dpse_GA18290

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17721

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

MDE:

SCAC:

LCQ:

AGA:	AgaP_AGAP006821

ACOZ:

AARA:

AAG:

AALB:

CQU:	CpipJ_CPIJ002342

CPII:

CNS:

AME:

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:	114871649 114871657

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105669845 105669846

PGC:

OBO:

PCF:

PFUC:

VPS:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

DPA:

SOY:	115881821 115888029

ATD:

109599494

CSET:

123306918

AGB:	108914001 108916293

LDC:	111504790 111504795

NVL:

APLN:

PPYR:

OTU:

BMOR:

100500748(at1) 101738252 105841738

BMAN:

114244590 114244618 114244619

MSEX:

115451051 115451052 115451054 115451059

DPL:	KGM_206001 KGM_206002

BANY:

112047648 112047649 112047650

PMAC:

106716645 106716779 106716780

PPOT:

106102070 106102197 106102490

PXU:	106114431 106114531

PRAP:

111000172 111000181 111000183

ZCE:	119831596 119831597 119831950

HAW:	110379955 110379956 110379969 110379978 110379979

TNL:	113502219 113502224 113502233 113502255

OFU:	114364375 114364376 114364383

PXY:	105384038 105384039 105384060 105394710 105394722 105394723 105394725 105396785 105396788

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM043260

FOC:

113207220

ZNE:

110827383

CSEC:

111863264

FCD:	110860027 110860110

DPX:	DAPPUDRAFT_58917

DMK:	116923473 123472519

PVM:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

HAZT:

EAF:

ISC:	IscW_ISCW002623

DSV:

RSAN:

RMP:

VDE:

VJA:

DPTE:

DFR:

CSCU:

PTEP:

SDM:

CEL:	CELE_F53A2.7(acaa-2)

CBR:

CBG_24278

NAI:	NECAME_09686

HRO:	HELRODRAFT_186335

LGI:	LOTGIDRAFT_219437

PCAN:

112560427

BGT:

106077935

GAE:

121380802

HRF:	124122952 124140552

HRJ:

CRG:

MYI:

PMAX:

MMER:

OBI:

OSN:

LAK:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:	100208472 101239169

TAD:	TRIADDRAFT_19473

AQU:

100636926

CNE:

CNA05060

CNB:

CNBA4880

CGI:	CGB_A5350W

TMS:	TREMEDRAFT_24275

TASA:

A1Q1_00430

UMA:	UMAG_03298

PFP:	PFL1_05545

MGL:

MGL_1340

MRT:

MRET_4021

MSYM:

MSY001_0303

PGR:	PGTG_00588

MLR:	MELLADRAFT_47555

MBR:	MONBRDRAFT_38241

SRE:	PTSG_00975

PTI:	PHATRDRAFT_45947

FCY:	FRACYDRAFT_268162(ACAT2)

TPS:	THAPSDRAFT_34809(KCT1)

NGD:	NGA_0450401(KCT2)

PIF:	PITG_07197

PSOJ:

PHYSODRAFT_480767

SPAR:

SPRG_15243

» show all

Reference

PMID:8241273

Authors

Abe H, Ohtake A, Yamamoto S, Satoh Y, Takayanagi M, Amaya Y, Takiguchi M, Sakuraba H, Suzuki Y, Mori M, et al.

Title

Cloning and sequence analysis of a full length cDNA encoding human mitochondrial 3-oxoacyl-CoA thiolase.

Journal

Biochim Biophys Acta 1216:304-6 (1993)
DOI:10.1016/0167-4781(93)90160-f

Sequence

[hsa:10449]

Reference

PMID:25478839

Authors

Kiema TR, Harijan RK, Strozyk M, Fukao T, Alexson SE, Wierenga RK.

Title

The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities.

Journal

Acta Crystallogr D Biol Crystallogr 70:3212-25 (2014)
DOI:10.1107/S1399004714023827

Sequence

[hsa:10449]

LinkDB

DBGET integrated database retrieval system