KEGG ORTHOLOGY: K12910

ORTHOLOGY: K12910

Entry

K12910 Tight KO

Name

pmmS

Definition

2-phosphinomethylmalate synthase [EC:2.3.3.18]

Pathway

ko00440

Phosphonate and phosphinate metabolism

ko01110

Biosynthesis of secondary metabolites

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K12910  pmmS; 2-phosphinomethylmalate synthase
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.18  2-phosphinomethylmalate synthase
     K12910  pmmS; 2-phosphinomethylmalate synthase

Other DBs

RN:

R08870

Genes

AG:	AAU00086(pms) BAA90528(pmmS)

Reference

PMID:19489722

Authors

Metcalf WW, van der Donk WA

Title

Biosynthesis of phosphonic and phosphinic acid natural products.

Journal

Annu Rev Biochem 78:65-94 (2009)
DOI:10.1146/annurev.biochem.78.091707.100215

Reference

PMID:1368511

Authors

Shimotohno KW, Imai S, Murakami T, Seto H

Title

Purification and characterization of citrate synthase from Streptomyces hygroscopicus SF-1293 and comparison of its properties with those of 2-phosphinomethylmalic acid synthase.

Journal

Agric Biol Chem 54:463-70 (1990)
DOI:10.1271/bbb1961.54.463

Sequence

[ag:BAA90528]

LinkDB

ENZYME: 2.3.3.18

Entry

EC 2.3.3.18 Enzyme

Name

2-phosphinomethylmalate synthase;
pmmS (gene name)

Class

Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer

Sysname

acetyl-CoA:phosphinopyruvate C-acetyltransferase (thioester-hydrolysing, phosphinomethylmalate-forming)

Reaction(IUBMB)

acetyl-CoA + H2O + 3-(hydroxyphosphinoyl)pyruvate = phosphinomethylmalate + CoA [RN:R08870]

Reaction(KEGG)

R08870

Substrate

acetyl-CoA [CPD:C00024];
H2O [CPD:C00001];
3-(hydroxyphosphinoyl)pyruvate

Product

phosphinomethylmalate;
CoA [CPD:C00010]

Comment

The enzyme, characterized from the bacterium Streptomyces hygroscopicus, participates in the pathway for bialaphos biosynthesis. It requires a divalent metal ion and can also act on oxaloacetate.

History

EC 2.3.3.18 created 2017

Pathway

ec00440

Phosphonate and phosphinate metabolism

ec01110

Biosynthesis of secondary metabolites

Orthology

K12910

2-phosphinomethylmalate synthase

Reference

1 [PMID:3170341]

Authors

Shimotohno KW, Seto H, Otake N, Imai S, Murakami T

Title

Studies on the biosynthesis of bialaphos (SF-1293). 8. Purification and characterization of 2-phosphinomethylmalic acid synthase from Streptomyces hygroscopicus SF-1293.

Journal

J Antibiot (Tokyo) 41:1057-65 (1988)
DOI:10.7164/antibiotics.41.1057

Reference

2 [PMID:1368511]

Authors

Shimotohno KW, Imai S, Murakami T, Seto H

Title

Purification and characterization of citrate synthase from Streptomyces hygroscopicus SF-1293 and comparison of its properties with those of 2-phosphinomethylmalic acid synthase.

Journal

Agric Biol Chem 54:463-70 (1990)
DOI:10.1271/bbb1961.54.463

Sequence

[ag:BAA90528]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.3.18

IUBMB Enzyme Nomenclature:

2.3.3.18

ExPASy - ENZYME nomenclature database:

2.3.3.18

BRENDA, the Enzyme Database: