KEGG   ORTHOLOGY: K13272
Entry
K13272                      KO                                     

Name
AOMT, CROMT2
Definition
flavonoid O-methyltransferase [EC:2.1.1.267]
Pathway
ko00944  Flavone and flavonol biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00944 Flavone and flavonol biosynthesis
    K13272  AOMT, CROMT2; flavonoid O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.267  flavonoid 3',5'-methyltransferase
     K13272  AOMT, CROMT2; flavonoid O-methyltransferase
Other DBs
RN: R06815 R06816
GO: 0033799 0070448
Genes
VVI: 100233134(FAOMT) 100245452 100250567 100250579
AG: AAM97497(OMT2)
Reference
  Authors
Cacace S, Schroder G, Wehinger E, Strack D, Schmidt J, Schroder J
  Title
A flavonol O-methyltransferase from Catharanthus roseus performing two sequential methylations.
  Journal
Phytochemistry 62:127-37 (2003)
DOI:10.1016/S0031-9422(02)00483-1
  Sequence
Reference
  Authors
Hugueney P, Provenzano S, Verries C, Ferrandino A, Meudec E, Batelli G, Merdinoglu D, Cheynier V, Schubert A, Ageorges A
  Title
A novel cation-dependent O-methyltransferase involved in anthocyanin methylation in grapevine.
  Journal
Plant Physiol 150:2057-70 (2009)
DOI:10.1104/pp.109.140376
  Sequence
[vvi:100233134]
LinkDB

KEGG   ENZYME: 2.1.1.267
Entry
EC 2.1.1.267                Enzyme                                 

Name
flavonoid 3',5'-methyltransferase;
AOMT;
CrOMT2
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:flavonoid 3'-O-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + a 3'-hydroxyflavonoid = S-adenosyl-L-homocysteine + a 3'-methoxyflavonoid;
(2) S-adenosyl-L-methionine + a 5'-hydroxy-3'-methoxyflavonoid = S-adenosyl-L-homocysteine + a 3',5'-dimethoxyflavonoid
Reaction(KEGG)
(other) R06815 R06816
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3'-hydroxyflavonoid [CPD:C02790];
5'-hydroxy-3'-methoxyflavonoid
Product
S-adenosyl-L-homocysteine [CPD:C00021];
3'-methoxyflavonoid;
3',5'-dimethoxyflavonoid
Comment
Isolated from Vitis vinifera (grape) [2]. Most active with delphinidin 3-glucoside but also acts on cyanidin 3-glucoside, cyanidin, myricetin, quercetin and quercetin 3-glucoside. The enzyme from Catharanthus roseus was most active with myricetin [1].
History
EC 2.1.1.267 created 2013, modified 2014
Pathway
ec00944  Flavone and flavonol biosynthesis
Orthology
K13272  flavonoid O-methyltransferase
Genes
VVI: 100233134(FAOMT) 100245452 100250567 100250579
Reference
1  [PMID:12482447]
  Authors
Cacace S, Schroder G, Wehinger E, Strack D, Schmidt J, Schroder J.
  Title
A flavonol O-methyltransferase from Catharanthus roseus performing two sequential methylations.
  Journal
Phytochemistry 62:127-37 (2003)
DOI:10.1016/S0031-9422(02)00483-1
  Sequence
Reference
2  [PMID:19525322]
  Authors
Hugueney P, Provenzano S, Verries C, Ferrandino A, Meudec E, Batelli G, Merdinoglu D, Cheynier V, Schubert A, Ageorges A
  Title
A novel cation-dependent O-methyltransferase involved in anthocyanin methylation  in grapevine.
  Journal
Plant Physiol 150:2057-70 (2009)
DOI:10.1104/pp.109.140376
  Sequence
[vvi:100233134]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.267
IUBMB Enzyme Nomenclature: 2.1.1.267
ExPASy - ENZYME nomenclature database: 2.1.1.267
BRENDA, the Enzyme Database: 2.1.1.267
LinkDB

KEGG   REACTION: R06815
Entry
R06815                      Reaction                               

Name
S-adenosyl-L-methionine:myricetin O-methyltransferase
Definition
Myricetin + S-Adenosyl-L-methionine <=> Laricitrin + S-Adenosyl-L-homocysteine
Equation
Reaction class
RC00003  C00019_C00021
RC00392  C10107_C12633
Enzyme
Pathway
rn00944  Flavone and flavonol biosynthesis
Orthology
K13272  flavonoid O-methyltransferase [EC:2.1.1.267]
Other DBs
RHEA: 25632
LinkDB

DBGET integrated database retrieval system