KEGG   ORTHOLOGY: K15966
Entry
K15966            Tight     KO                                     
Symbol
mtmOIV
Name
monooxygenase [EC:1.14.13.-]
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00782  Mithramycin biosynthesis, 4-demethylpremithramycinone => mithramycin
Reaction
R09353  premithramycin-B,NADPH:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15966  mtmOIV; monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15966  mtmOIV; monooxygenase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K15966  mtmOIV; monooxygenase
Genes
AG: CAK50794(mtmOIV)
Reference
  Authors
Gibson M, Nur-e-alam M, Lipata F, Oliveira MA, Rohr J
  Title
Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus.
  Journal
J Am Chem Soc 127:17594-5 (2005)
DOI:10.1021/ja055750t
Reference
  Authors
Rodriguez D, Quiros LM, Brana AF, Salas JA
  Title
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.
  Journal
J Bacteriol 185:3962-5 (2003)
DOI:10.1128/JB.185.13.3962-3965.2003
  Sequence
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