Entry
Symbol
mtmOIV
Name
monooxygenase [EC:1.14.13.-]
Pathway
map01057 Biosynthesis of type II polyketide products
map01110 Biosynthesis of secondary metabolites
Module
M00782 Mithramycin biosynthesis, 4-demethylpremithramycinone => mithramycin
Reaction
R09353 premithramycin-B,NADPH:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
01057 Biosynthesis of type II polyketide products
K15966 mtmOIV; monooxygenase
09180 Brite Hierarchies
09181 Protein families: metabolism
01008 Polyketide biosynthesis proteins
K15966 mtmOIV; monooxygenase
Polyketide biosynthesis proteins [BR:ko01008 ]
Polyketide tailoring proteins
Oxygenase
K15966 mtmOIV; monooxygenase
BRITE hierarchy
Genes
Taxonomy UniProt
Reference
Authors
Gibson M, Nur-e-alam M, Lipata F, Oliveira MA, Rohr J
Title
Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus.
Journal
Reference
Authors
Rodriguez D, Quiros LM, Brana AF, Salas JA
Title
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.
Journal
Sequence
LinkDB
All DBs