KEGG   NETWORK: N00287
Entry
N00287                      Network                                

Name
ESR1-positive to nuclear-initiated estrogen signaling pathway
Definition
E2 -- (ESR*+(NCOA3,NCOA1)) => (CCND1,MYC)
  Expanded
C00951 -- (2099v1+(8202,8648)) => (595,4609)
Class
nt06227 Nuclear receptor signaling
nt06270 Breast cancer
Type
Variant
Pathway
hsa05224  Breast cancer
Disease
H00031  Breast cancer
Gene
2099  ESR1; estrogen receptor 1
8202  NCOA3; nuclear receptor coactivator 3
8648  NCOA1; nuclear receptor coactivator 1
595  CCND1; cyclin D1
4609  MYC; MYC proto-oncogene, bHLH transcription factor
Variant
2099v1 (ESR*)  ESR1 positive
Metabolite
C00951  Estradiol-17beta
Reference
  Authors
Wu VS, Kanaya N, Lo C, Mortimer J, Chen S
  Title
From bench to bedside: What do we know about hormone receptor-positive and human epidermal growth factor receptor 2-positive breast cancer?
  Journal
J Steroid Biochem Mol Biol 153:45-53 (2015)
DOI:10.1016/j.jsbmb.2015.05.005
Reference
  Authors
Butt AJ, McNeil CM, Musgrove EA, Sutherland RL
  Title
Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.
  Journal
Endocr Relat Cancer 12 Suppl 1:S47-59 (2005)
DOI:10.1677/erc.1.00993
Reference
  Authors
Zhang MH, Man HT, Zhao XD, Dong N, Ma SL
  Title
Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).
  Journal
Biomed Rep 2:41-52 (2014)
DOI:10.3892/br.2013.187
Reference
  Authors
Dasgupta S, Lonard DM, O'Malley BW
  Title
Nuclear receptor coactivators: master regulators of human health and disease.
  Journal
Annu Rev Med 65:279-92 (2014)
DOI:10.1146/annurev-med-051812-145316
Reference
  Authors
Manavathi B, Samanthapudi VS, Gajulapalli VN
  Title
Estrogen receptor coregulators and pioneer factors: the orchestrators of mammary gland cell fate and development.
  Journal
Front Cell Dev Biol 2:34 (2014)
DOI:10.3389/fcell.2014.00034
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