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KEGG NETWORK Database

KEGG NETWORK represents a renewed attempt by KEGG to capture knowledge on diseases and drugs in terms of perturbed molecular networks (see Background of KEGG DISEASE). It accumulates variations of molecular interaction/reaction networks in Homo sapiens distinguishing gene variants and other perturbants. The KEGG NETWORK database consists of "network elements" identified by N numbers and groupings of network elements in "network variation maps" identified by nt numbers. For example,
N00001
EGF -> EGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> CCND1
is a reference network element corresponding to a conserved subpathway in the KEGG pathway maps, such as in hsa04010 (MAPK signaling pathway). A number of variations for this reference network element are collected including:
N00014
EGFR* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> CCND1
N00002
BCR-ABL -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
which are found in the disease pathway maps of hsa05223 (non-small cell lung cancer) and hsa05220 (chronic myeloid leukemia), respectively. These and other related network elements are shown in the network variation map nt06210 for MAPK (ERK) signaling, where reference network elements are shown in green and gene variants are marked in red. Here red-marked gene names are linked to KEGG VARIANT entries with details of variations, which is the main difference from the traditional KEGG pathway maps where red-marked gene names are linked to reference GENES entries.

The nodes and edges of network elements currently used are as follows.

Node Identifier Coloring
Human reference gene/protein
Human gene variant
Viral or other pathogen gene/protein
Metabolite and other chemical compound
Drug
hsa ID
variant ID
K number
C number
D number
None
Red
Purple
None
Blue

Edge (signaling network) Edge (metabolic network) Text Symbol
Activation (single- or multi-step)
Inhibition (single- or multi-step)
Complex formation
Missing interaction
Expression (single-step)
Repression (single-step)
Enzymatic reaction
 
Substrate binding
Missing reaction
Enhanced reaction
 
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Network Variation Maps

06200   Cancer Network
Cancer Types

See Color codes of cancer types
06300   Endocrine Network
Endocrine Diseases
06100   Virus Network
Viruses


Last updated: October 1, 2018
KEGG GenomeNet Kanehisa Laboratories