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Network Variation Maps

KEGG NETWORK represents a renewed attempt by KEGG to capture knowledge of diseases and drugs in terms of perturbed molecular networks (see Background of KEGG DISEASE). It accumulates variations of molecular interaction/reaction networks in terms of "network variation maps" consisting of "network elements". Each network element is identified by the N number (such as N00014) and each variation map is identified by the nt number (such as nt06210). The notation of network variation maps is as follows.
Network element Coloring
Reference network Green
Variant network containing
   Human gene variant
   Pathogen gene/protein
   Environmental factor

Red
Purple
Blue
Drug-target relation Navy
Edge Signaling network Metabolic network






Activation
Inhibition
Complex formation
Missing interaction
Expression
Repression
 
Enzyme-product relation

Substrate-enzyme relation
Missing reaction


Enzyme-enzyme relation


Cancers

See Color codes of cancer types
Neurodegenerative diseases
Endocrine and metabolic diseases
(Disorders of hormone systems)

06320
APOB-LDLR signaling (Hyperlipidemia)
06017
Glycogen metabolism (Glycogen storage disease)
06023
Galactose degradation (Galactosemia)
06020
beta-Oxidation in mitochondria (Disorders of mitochondrial fatty-acid oxidation)
06021
beta-Oxidation in peroxisome (Peroxisomal beta-oxidation enzyme deficiency)
06022
Bile acid biosynthesis (Congenital bile acid synthesis defect)
06024
Valine, leucine and isoleucine degradation (Maple syrup urine disease, etc.)
06010
Urea cycle (Urea cycle disorders)
06016
Phenylalanine and tyrosine metabolism (Phenylketonuria, Tyrosinemia, Alkaptonuria)
06026
Glutathione biosynthesis (Anemia due to disorders of glutathione metabolism)
06025
Molybdenum cofactor biosynthesis (Xanthinuria)
06011
Heme biosynthesis (Porphyria)
06014
Sphingolipid degradation (Sphingolipidosis)
06012
Glycosmainoglycan degradation (Mucopolysaccharidosis)
06015
N-Glycan biosynthesis (Congenital disorder of glycosylation)
06013
O-Glycan biosynthesis (Muscular dystrophy-dystroglycanopathy)
06018
GPI-anchor biosynthesis (Inherited glycosylphosphatidylinositol deficiency)
Viral and bacterial infections
06160*
HTLV-1
06161
HIV-1
06169
MV
06170
IAV
06162*
HBV
06163*
HCV
06168
HSV-1
06167
HCMV
06164*
KSHV
06165*
EBV
06166*
HPV

* Oncovirus


Last updated: July 27, 2020
KEGG GenomeNet Kanehisa Laboratories