KEGG   Ailuropoda melanoleuca (giant panda): 100464196
Entry
100464196         CDS       T01329                                 

Gene name
NRAS
Definition
(RefSeq) GTPase NRas
  KO
K07828  GTPase NRas
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
aml01521  EGFR tyrosine kinase inhibitor resistance
aml01522  Endocrine resistance
aml04010  MAPK signaling pathway
aml04012  ErbB signaling pathway
aml04014  Ras signaling pathway
aml04015  Rap1 signaling pathway
aml04062  Chemokine signaling pathway
aml04068  FoxO signaling pathway
aml04071  Sphingolipid signaling pathway
aml04072  Phospholipase D signaling pathway
aml04137  Mitophagy - animal
aml04140  Autophagy - animal
aml04150  mTOR signaling pathway
aml04151  PI3K-Akt signaling pathway
aml04210  Apoptosis
aml04211  Longevity regulating pathway
aml04213  Longevity regulating pathway - multiple species
aml04218  Cellular senescence
aml04360  Axon guidance
aml04370  VEGF signaling pathway
aml04371  Apelin signaling pathway
aml04540  Gap junction
aml04550  Signaling pathways regulating pluripotency of stem cells
aml04625  C-type lectin receptor signaling pathway
aml04650  Natural killer cell mediated cytotoxicity
aml04660  T cell receptor signaling pathway
aml04662  B cell receptor signaling pathway
aml04664  Fc epsilon RI signaling pathway
aml04714  Thermogenesis
aml04720  Long-term potentiation
aml04722  Neurotrophin signaling pathway
aml04725  Cholinergic synapse
aml04726  Serotonergic synapse
aml04730  Long-term depression
aml04810  Regulation of actin cytoskeleton
aml04910  Insulin signaling pathway
aml04912  GnRH signaling pathway
aml04915  Estrogen signaling pathway
aml04916  Melanogenesis
aml04917  Prolactin signaling pathway
aml04919  Thyroid hormone signaling pathway
aml04921  Oxytocin signaling pathway
aml04926  Relaxin signaling pathway
aml04929  GnRH secretion
aml04933  AGE-RAGE signaling pathway in diabetic complications
aml04935  Growth hormone synthesis, secretion and action
aml05010  Alzheimer disease
aml05022  Pathways of neurodegeneration - multiple diseases
aml05034  Alcoholism
aml05160  Hepatitis C
aml05161  Hepatitis B
aml05163  Human cytomegalovirus infection
aml05165  Human papillomavirus infection
aml05166  Human T-cell leukemia virus 1 infection
aml05167  Kaposi sarcoma-associated herpesvirus infection
aml05170  Human immunodeficiency virus 1 infection
aml05200  Pathways in cancer
aml05203  Viral carcinogenesis
aml05205  Proteoglycans in cancer
aml05206  MicroRNAs in cancer
aml05210  Colorectal cancer
aml05211  Renal cell carcinoma
aml05213  Endometrial cancer
aml05214  Glioma
aml05215  Prostate cancer
aml05216  Thyroid cancer
aml05218  Melanoma
aml05219  Bladder cancer
aml05220  Chronic myeloid leukemia
aml05221  Acute myeloid leukemia
aml05223  Non-small cell lung cancer
aml05224  Breast cancer
aml05225  Hepatocellular carcinoma
aml05226  Gastric cancer
aml05230  Central carbon metabolism in cancer
aml05231  Choline metabolism in cancer
aml05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:aml00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100464196 (NRAS)
   04012 ErbB signaling pathway
    100464196 (NRAS)
   04014 Ras signaling pathway
    100464196 (NRAS)
   04015 Rap1 signaling pathway
    100464196 (NRAS)
   04370 VEGF signaling pathway
    100464196 (NRAS)
   04371 Apelin signaling pathway
    100464196 (NRAS)
   04068 FoxO signaling pathway
    100464196 (NRAS)
   04072 Phospholipase D signaling pathway
    100464196 (NRAS)
   04071 Sphingolipid signaling pathway
    100464196 (NRAS)
   04151 PI3K-Akt signaling pathway
    100464196 (NRAS)
   04150 mTOR signaling pathway
    100464196 (NRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100464196 (NRAS)
   04137 Mitophagy - animal
    100464196 (NRAS)
  09143 Cell growth and death
   04210 Apoptosis
    100464196 (NRAS)
   04218 Cellular senescence
    100464196 (NRAS)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100464196 (NRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    100464196 (NRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100464196 (NRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    100464196 (NRAS)
   04650 Natural killer cell mediated cytotoxicity
    100464196 (NRAS)
   04660 T cell receptor signaling pathway
    100464196 (NRAS)
   04662 B cell receptor signaling pathway
    100464196 (NRAS)
   04664 Fc epsilon RI signaling pathway
    100464196 (NRAS)
   04062 Chemokine signaling pathway
    100464196 (NRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100464196 (NRAS)
   04929 GnRH secretion
    100464196 (NRAS)
   04912 GnRH signaling pathway
    100464196 (NRAS)
   04915 Estrogen signaling pathway
    100464196 (NRAS)
   04917 Prolactin signaling pathway
    100464196 (NRAS)
   04921 Oxytocin signaling pathway
    100464196 (NRAS)
   04926 Relaxin signaling pathway
    100464196 (NRAS)
   04935 Growth hormone synthesis, secretion and action
    100464196 (NRAS)
   04919 Thyroid hormone signaling pathway
    100464196 (NRAS)
   04916 Melanogenesis
    100464196 (NRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    100464196 (NRAS)
   04726 Serotonergic synapse
    100464196 (NRAS)
   04720 Long-term potentiation
    100464196 (NRAS)
   04730 Long-term depression
    100464196 (NRAS)
   04722 Neurotrophin signaling pathway
    100464196 (NRAS)
  09158 Development and regeneration
   04360 Axon guidance
    100464196 (NRAS)
  09149 Aging
   04211 Longevity regulating pathway
    100464196 (NRAS)
   04213 Longevity regulating pathway - multiple species
    100464196 (NRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    100464196 (NRAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100464196 (NRAS)
   05206 MicroRNAs in cancer
    100464196 (NRAS)
   05205 Proteoglycans in cancer
    100464196 (NRAS)
   05203 Viral carcinogenesis
    100464196 (NRAS)
   05230 Central carbon metabolism in cancer
    100464196 (NRAS)
   05231 Choline metabolism in cancer
    100464196 (NRAS)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100464196 (NRAS)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100464196 (NRAS)
   05225 Hepatocellular carcinoma
    100464196 (NRAS)
   05226 Gastric cancer
    100464196 (NRAS)
   05214 Glioma
    100464196 (NRAS)
   05216 Thyroid cancer
    100464196 (NRAS)
   05221 Acute myeloid leukemia
    100464196 (NRAS)
   05220 Chronic myeloid leukemia
    100464196 (NRAS)
   05218 Melanoma
    100464196 (NRAS)
   05211 Renal cell carcinoma
    100464196 (NRAS)
   05219 Bladder cancer
    100464196 (NRAS)
   05215 Prostate cancer
    100464196 (NRAS)
   05213 Endometrial cancer
    100464196 (NRAS)
   05224 Breast cancer
    100464196 (NRAS)
   05223 Non-small cell lung cancer
    100464196 (NRAS)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100464196 (NRAS)
   05022 Pathways of neurodegeneration - multiple diseases
    100464196 (NRAS)
  09165 Substance dependence
   05034 Alcoholism
    100464196 (NRAS)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100464196 (NRAS)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100464196 (NRAS)
   05170 Human immunodeficiency virus 1 infection
    100464196 (NRAS)
   05161 Hepatitis B
    100464196 (NRAS)
   05160 Hepatitis C
    100464196 (NRAS)
   05163 Human cytomegalovirus infection
    100464196 (NRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100464196 (NRAS)
   05165 Human papillomavirus infection
    100464196 (NRAS)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100464196 (NRAS)
   01522 Endocrine resistance
    100464196 (NRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:aml04131]
    100464196 (NRAS)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:aml04147]
    100464196 (NRAS)
   04031 GTP-binding proteins [BR:aml04031]
    100464196 (NRAS)
Membrane trafficking [BR:aml04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    100464196 (NRAS)
Exosome [BR:aml04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   100464196 (NRAS)
  Exosomal proteins of other body fluids (saliva and urine)
   100464196 (NRAS)
  Exosomal proteins of breast cancer cells
   100464196 (NRAS)
  Exosomal proteins of colorectal cancer cells
   100464196 (NRAS)
GTP-binding proteins [BR:aml04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    100464196 (NRAS)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 FeoB_N Septin ParA Ldh_1_N
Other DBs
NCBI-GeneID: 100464196
NCBI-ProteinID: XP_002928659
Ensembl: ENSAMEG00000017134
UniProt: D2I0G3
LinkDB
Position
2
AA seq 189 aa
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL
PTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQG
CMGLPCVVM
NT seq 570 nt   +upstreamnt  +downstreamnt
atgactgagtacaaactggtggtggttggagcaggtggtgtcgggaaaagcgcactgaca
atccagctaatccagaaccactttgtagatgaatatgatcccaccatagaggattcttac
cgaaaacaggtggttatagacggtgaaacctgtctgttggacatactggatacagctggt
caagaggagtacagtgccatgagagaccaatacatgaggacaggcgaaggtttcctctgt
gtatttgccatcaataatagcaaatcatttgcagatattaacctctacagggaacagatt
aagcgagtcaaagattcagatgacgtacctatggtgctagtaggaaataagtgtgatttg
ccaacaaggacagtggacacaaaacaagcccacgaactggccaagagttatgggattcca
ttcattgaaacctcagccaagaccagacagggtgttgaagatgccttttacacactggta
agagaaatacgtcagtaccgaatgaagaaactcaacagcagtgatgatgggactcaaggt
tgtatggggttaccgtgtgtggtgatgtaa

KEGG   Ailuropoda melanoleuca (giant panda): 100473836
Entry
100473836         CDS       T01329                                 

Gene name
HRAS
Definition
(RefSeq) GTPase HRas isoform X1
  KO
K02833  GTPase HRas
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
aml01521  EGFR tyrosine kinase inhibitor resistance
aml01522  Endocrine resistance
aml04010  MAPK signaling pathway
aml04012  ErbB signaling pathway
aml04014  Ras signaling pathway
aml04015  Rap1 signaling pathway
aml04062  Chemokine signaling pathway
aml04068  FoxO signaling pathway
aml04071  Sphingolipid signaling pathway
aml04072  Phospholipase D signaling pathway
aml04137  Mitophagy - animal
aml04140  Autophagy - animal
aml04144  Endocytosis
aml04150  mTOR signaling pathway
aml04151  PI3K-Akt signaling pathway
aml04210  Apoptosis
aml04211  Longevity regulating pathway
aml04213  Longevity regulating pathway - multiple species
aml04218  Cellular senescence
aml04360  Axon guidance
aml04370  VEGF signaling pathway
aml04371  Apelin signaling pathway
aml04510  Focal adhesion
aml04540  Gap junction
aml04550  Signaling pathways regulating pluripotency of stem cells
aml04625  C-type lectin receptor signaling pathway
aml04630  JAK-STAT signaling pathway
aml04650  Natural killer cell mediated cytotoxicity
aml04660  T cell receptor signaling pathway
aml04662  B cell receptor signaling pathway
aml04664  Fc epsilon RI signaling pathway
aml04714  Thermogenesis
aml04720  Long-term potentiation
aml04722  Neurotrophin signaling pathway
aml04725  Cholinergic synapse
aml04726  Serotonergic synapse
aml04730  Long-term depression
aml04810  Regulation of actin cytoskeleton
aml04910  Insulin signaling pathway
aml04912  GnRH signaling pathway
aml04915  Estrogen signaling pathway
aml04916  Melanogenesis
aml04917  Prolactin signaling pathway
aml04919  Thyroid hormone signaling pathway
aml04921  Oxytocin signaling pathway
aml04926  Relaxin signaling pathway
aml04929  GnRH secretion
aml04933  AGE-RAGE signaling pathway in diabetic complications
aml04935  Growth hormone synthesis, secretion and action
aml05010  Alzheimer disease
aml05022  Pathways of neurodegeneration - multiple diseases
aml05034  Alcoholism
aml05132  Salmonella infection
aml05160  Hepatitis C
aml05161  Hepatitis B
aml05163  Human cytomegalovirus infection
aml05165  Human papillomavirus infection
aml05166  Human T-cell leukemia virus 1 infection
aml05167  Kaposi sarcoma-associated herpesvirus infection
aml05170  Human immunodeficiency virus 1 infection
aml05200  Pathways in cancer
aml05203  Viral carcinogenesis
aml05205  Proteoglycans in cancer
aml05206  MicroRNAs in cancer
aml05210  Colorectal cancer
aml05211  Renal cell carcinoma
aml05213  Endometrial cancer
aml05214  Glioma
aml05215  Prostate cancer
aml05216  Thyroid cancer
aml05218  Melanoma
aml05219  Bladder cancer
aml05220  Chronic myeloid leukemia
aml05221  Acute myeloid leukemia
aml05223  Non-small cell lung cancer
aml05224  Breast cancer
aml05225  Hepatocellular carcinoma
aml05226  Gastric cancer
aml05230  Central carbon metabolism in cancer
aml05231  Choline metabolism in cancer
aml05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:aml00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100473836 (HRAS)
   04012 ErbB signaling pathway
    100473836 (HRAS)
   04014 Ras signaling pathway
    100473836 (HRAS)
   04015 Rap1 signaling pathway
    100473836 (HRAS)
   04370 VEGF signaling pathway
    100473836 (HRAS)
   04371 Apelin signaling pathway
    100473836 (HRAS)
   04630 JAK-STAT signaling pathway
    100473836 (HRAS)
   04068 FoxO signaling pathway
    100473836 (HRAS)
   04072 Phospholipase D signaling pathway
    100473836 (HRAS)
   04071 Sphingolipid signaling pathway
    100473836 (HRAS)
   04151 PI3K-Akt signaling pathway
    100473836 (HRAS)
   04150 mTOR signaling pathway
    100473836 (HRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    100473836 (HRAS)
   04140 Autophagy - animal
    100473836 (HRAS)
   04137 Mitophagy - animal
    100473836 (HRAS)
  09143 Cell growth and death
   04210 Apoptosis
    100473836 (HRAS)
   04218 Cellular senescence
    100473836 (HRAS)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100473836 (HRAS)
   04540 Gap junction
    100473836 (HRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    100473836 (HRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100473836 (HRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    100473836 (HRAS)
   04650 Natural killer cell mediated cytotoxicity
    100473836 (HRAS)
   04660 T cell receptor signaling pathway
    100473836 (HRAS)
   04662 B cell receptor signaling pathway
    100473836 (HRAS)
   04664 Fc epsilon RI signaling pathway
    100473836 (HRAS)
   04062 Chemokine signaling pathway
    100473836 (HRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100473836 (HRAS)
   04929 GnRH secretion
    100473836 (HRAS)
   04912 GnRH signaling pathway
    100473836 (HRAS)
   04915 Estrogen signaling pathway
    100473836 (HRAS)
   04917 Prolactin signaling pathway
    100473836 (HRAS)
   04921 Oxytocin signaling pathway
    100473836 (HRAS)
   04926 Relaxin signaling pathway
    100473836 (HRAS)
   04935 Growth hormone synthesis, secretion and action
    100473836 (HRAS)
   04919 Thyroid hormone signaling pathway
    100473836 (HRAS)
   04916 Melanogenesis
    100473836 (HRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    100473836 (HRAS)
   04726 Serotonergic synapse
    100473836 (HRAS)
   04720 Long-term potentiation
    100473836 (HRAS)
   04730 Long-term depression
    100473836 (HRAS)
   04722 Neurotrophin signaling pathway
    100473836 (HRAS)
  09158 Development and regeneration
   04360 Axon guidance
    100473836 (HRAS)
  09149 Aging
   04211 Longevity regulating pathway
    100473836 (HRAS)
   04213 Longevity regulating pathway - multiple species
    100473836 (HRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    100473836 (HRAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100473836 (HRAS)
   05206 MicroRNAs in cancer
    100473836 (HRAS)
   05205 Proteoglycans in cancer
    100473836 (HRAS)
   05203 Viral carcinogenesis
    100473836 (HRAS)
   05230 Central carbon metabolism in cancer
    100473836 (HRAS)
   05231 Choline metabolism in cancer
    100473836 (HRAS)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100473836 (HRAS)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100473836 (HRAS)
   05225 Hepatocellular carcinoma
    100473836 (HRAS)
   05226 Gastric cancer
    100473836 (HRAS)
   05214 Glioma
    100473836 (HRAS)
   05216 Thyroid cancer
    100473836 (HRAS)
   05221 Acute myeloid leukemia
    100473836 (HRAS)
   05220 Chronic myeloid leukemia
    100473836 (HRAS)
   05218 Melanoma
    100473836 (HRAS)
   05211 Renal cell carcinoma
    100473836 (HRAS)
   05219 Bladder cancer
    100473836 (HRAS)
   05215 Prostate cancer
    100473836 (HRAS)
   05213 Endometrial cancer
    100473836 (HRAS)
   05224 Breast cancer
    100473836 (HRAS)
   05223 Non-small cell lung cancer
    100473836 (HRAS)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100473836 (HRAS)
   05022 Pathways of neurodegeneration - multiple diseases
    100473836 (HRAS)
  09165 Substance dependence
   05034 Alcoholism
    100473836 (HRAS)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100473836 (HRAS)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100473836 (HRAS)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100473836 (HRAS)
   05170 Human immunodeficiency virus 1 infection
    100473836 (HRAS)
   05161 Hepatitis B
    100473836 (HRAS)
   05160 Hepatitis C
    100473836 (HRAS)
   05163 Human cytomegalovirus infection
    100473836 (HRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100473836 (HRAS)
   05165 Human papillomavirus infection
    100473836 (HRAS)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100473836 (HRAS)
   01522 Endocrine resistance
    100473836 (HRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:aml04131]
    100473836 (HRAS)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:aml04147]
    100473836 (HRAS)
   04031 GTP-binding proteins [BR:aml04031]
    100473836 (HRAS)
Membrane trafficking [BR:aml04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    100473836 (HRAS)
Exosome [BR:aml04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   100473836 (HRAS)
  Exosomal proteins of colorectal cancer cells
   100473836 (HRAS)
GTP-binding proteins [BR:aml04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    100473836 (HRAS)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 FeoB_N Gtr1_RagA ATP_bind_1 G-alpha Septin Ldh_1_N AAA_25
Other DBs
NCBI-GeneID: 100473836
NCBI-ProteinID: XP_019665744
UniProt: D2I2S4
LinkDB
Position
16
AA seq 189 aa
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKVRKLSPPDEGGPG
CLSCRCLLS
NT seq 570 nt   +upstreamnt  +downstreamnt
atgacggaatataagcttgtggtagtgggcgctggtggtgtggggaagagcgccctgacc
atccagctcattcagaaccactttgtggatgagtatgaccccaccatcgaggactcctat
cggaagcaagtggttatcgatggtgagacgtgcctgctggacattttggacacagcgggc
caggaagaatatagcgccatgcgggaccagtacatgcgcactggggaaggcttcctgtgt
gtgttcgccatcaataacaccaagtccttcgaggacatccaccagtacagggagcagatc
aaacgagtgaaggactccgatgacgtgcccatggtgctggtggggaacaagtgtgatctg
gctgcgcgcaccgtggagtcccggcaggcgcaggacctcgcccgcagctatggcatcccc
tacatcgagacgtcggccaagacgcgccagggcgtggaggacgccttctacacgctggtg
cgagagatccggcagcacaaggtgcggaagctgagcccgcccgacgaggggggcccgggc
tgcctgagctgcaggtgcctgctctcctga

KEGG   Ailuropoda melanoleuca (giant panda): 100483919
Entry
100483919         CDS       T01329                                 

Gene name
KRAS
Definition
(RefSeq) GTPase KRas isoform X1
  KO
K07827  GTPase KRas
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
aml01521  EGFR tyrosine kinase inhibitor resistance
aml01522  Endocrine resistance
aml04010  MAPK signaling pathway
aml04012  ErbB signaling pathway
aml04014  Ras signaling pathway
aml04015  Rap1 signaling pathway
aml04062  Chemokine signaling pathway
aml04068  FoxO signaling pathway
aml04071  Sphingolipid signaling pathway
aml04072  Phospholipase D signaling pathway
aml04137  Mitophagy - animal
aml04140  Autophagy - animal
aml04150  mTOR signaling pathway
aml04151  PI3K-Akt signaling pathway
aml04210  Apoptosis
aml04211  Longevity regulating pathway
aml04213  Longevity regulating pathway - multiple species
aml04218  Cellular senescence
aml04360  Axon guidance
aml04370  VEGF signaling pathway
aml04371  Apelin signaling pathway
aml04540  Gap junction
aml04550  Signaling pathways regulating pluripotency of stem cells
aml04625  C-type lectin receptor signaling pathway
aml04650  Natural killer cell mediated cytotoxicity
aml04660  T cell receptor signaling pathway
aml04662  B cell receptor signaling pathway
aml04664  Fc epsilon RI signaling pathway
aml04714  Thermogenesis
aml04720  Long-term potentiation
aml04722  Neurotrophin signaling pathway
aml04725  Cholinergic synapse
aml04726  Serotonergic synapse
aml04730  Long-term depression
aml04810  Regulation of actin cytoskeleton
aml04910  Insulin signaling pathway
aml04912  GnRH signaling pathway
aml04914  Progesterone-mediated oocyte maturation
aml04915  Estrogen signaling pathway
aml04916  Melanogenesis
aml04917  Prolactin signaling pathway
aml04919  Thyroid hormone signaling pathway
aml04921  Oxytocin signaling pathway
aml04926  Relaxin signaling pathway
aml04929  GnRH secretion
aml04933  AGE-RAGE signaling pathway in diabetic complications
aml04935  Growth hormone synthesis, secretion and action
aml04960  Aldosterone-regulated sodium reabsorption
aml05010  Alzheimer disease
aml05022  Pathways of neurodegeneration - multiple diseases
aml05034  Alcoholism
aml05160  Hepatitis C
aml05161  Hepatitis B
aml05163  Human cytomegalovirus infection
aml05165  Human papillomavirus infection
aml05166  Human T-cell leukemia virus 1 infection
aml05167  Kaposi sarcoma-associated herpesvirus infection
aml05170  Human immunodeficiency virus 1 infection
aml05200  Pathways in cancer
aml05203  Viral carcinogenesis
aml05205  Proteoglycans in cancer
aml05206  MicroRNAs in cancer
aml05210  Colorectal cancer
aml05211  Renal cell carcinoma
aml05212  Pancreatic cancer
aml05213  Endometrial cancer
aml05214  Glioma
aml05215  Prostate cancer
aml05216  Thyroid cancer
aml05218  Melanoma
aml05219  Bladder cancer
aml05220  Chronic myeloid leukemia
aml05221  Acute myeloid leukemia
aml05223  Non-small cell lung cancer
aml05224  Breast cancer
aml05225  Hepatocellular carcinoma
aml05226  Gastric cancer
aml05230  Central carbon metabolism in cancer
aml05231  Choline metabolism in cancer
aml05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:aml00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100483919 (KRAS)
   04012 ErbB signaling pathway
    100483919 (KRAS)
   04014 Ras signaling pathway
    100483919 (KRAS)
   04015 Rap1 signaling pathway
    100483919 (KRAS)
   04370 VEGF signaling pathway
    100483919 (KRAS)
   04371 Apelin signaling pathway
    100483919 (KRAS)
   04068 FoxO signaling pathway
    100483919 (KRAS)
   04072 Phospholipase D signaling pathway
    100483919 (KRAS)
   04071 Sphingolipid signaling pathway
    100483919 (KRAS)
   04151 PI3K-Akt signaling pathway
    100483919 (KRAS)
   04150 mTOR signaling pathway
    100483919 (KRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100483919 (KRAS)
   04137 Mitophagy - animal
    100483919 (KRAS)
  09143 Cell growth and death
   04210 Apoptosis
    100483919 (KRAS)
   04218 Cellular senescence
    100483919 (KRAS)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100483919 (KRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    100483919 (KRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100483919 (KRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    100483919 (KRAS)
   04650 Natural killer cell mediated cytotoxicity
    100483919 (KRAS)
   04660 T cell receptor signaling pathway
    100483919 (KRAS)
   04662 B cell receptor signaling pathway
    100483919 (KRAS)
   04664 Fc epsilon RI signaling pathway
    100483919 (KRAS)
   04062 Chemokine signaling pathway
    100483919 (KRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100483919 (KRAS)
   04929 GnRH secretion
    100483919 (KRAS)
   04912 GnRH signaling pathway
    100483919 (KRAS)
   04915 Estrogen signaling pathway
    100483919 (KRAS)
   04914 Progesterone-mediated oocyte maturation
    100483919 (KRAS)
   04917 Prolactin signaling pathway
    100483919 (KRAS)
   04921 Oxytocin signaling pathway
    100483919 (KRAS)
   04926 Relaxin signaling pathway
    100483919 (KRAS)
   04935 Growth hormone synthesis, secretion and action
    100483919 (KRAS)
   04919 Thyroid hormone signaling pathway
    100483919 (KRAS)
   04916 Melanogenesis
    100483919 (KRAS)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100483919 (KRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    100483919 (KRAS)
   04726 Serotonergic synapse
    100483919 (KRAS)
   04720 Long-term potentiation
    100483919 (KRAS)
   04730 Long-term depression
    100483919 (KRAS)
   04722 Neurotrophin signaling pathway
    100483919 (KRAS)
  09158 Development and regeneration
   04360 Axon guidance
    100483919 (KRAS)
  09149 Aging
   04211 Longevity regulating pathway
    100483919 (KRAS)
   04213 Longevity regulating pathway - multiple species
    100483919 (KRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    100483919 (KRAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100483919 (KRAS)
   05206 MicroRNAs in cancer
    100483919 (KRAS)
   05205 Proteoglycans in cancer
    100483919 (KRAS)
   05203 Viral carcinogenesis
    100483919 (KRAS)
   05230 Central carbon metabolism in cancer
    100483919 (KRAS)
   05231 Choline metabolism in cancer
    100483919 (KRAS)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100483919 (KRAS)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100483919 (KRAS)
   05212 Pancreatic cancer
    100483919 (KRAS)
   05225 Hepatocellular carcinoma
    100483919 (KRAS)
   05226 Gastric cancer
    100483919 (KRAS)
   05214 Glioma
    100483919 (KRAS)
   05216 Thyroid cancer
    100483919 (KRAS)
   05221 Acute myeloid leukemia
    100483919 (KRAS)
   05220 Chronic myeloid leukemia
    100483919 (KRAS)
   05218 Melanoma
    100483919 (KRAS)
   05211 Renal cell carcinoma
    100483919 (KRAS)
   05219 Bladder cancer
    100483919 (KRAS)
   05215 Prostate cancer
    100483919 (KRAS)
   05213 Endometrial cancer
    100483919 (KRAS)
   05224 Breast cancer
    100483919 (KRAS)
   05223 Non-small cell lung cancer
    100483919 (KRAS)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100483919 (KRAS)
   05022 Pathways of neurodegeneration - multiple diseases
    100483919 (KRAS)
  09165 Substance dependence
   05034 Alcoholism
    100483919 (KRAS)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100483919 (KRAS)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100483919 (KRAS)
   05170 Human immunodeficiency virus 1 infection
    100483919 (KRAS)
   05161 Hepatitis B
    100483919 (KRAS)
   05160 Hepatitis C
    100483919 (KRAS)
   05163 Human cytomegalovirus infection
    100483919 (KRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100483919 (KRAS)
   05165 Human papillomavirus infection
    100483919 (KRAS)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100483919 (KRAS)
   01522 Endocrine resistance
    100483919 (KRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:aml04131]
    100483919 (KRAS)
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins [BR:aml04031]
    100483919 (KRAS)
Membrane trafficking [BR:aml04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    100483919 (KRAS)
GTP-binding proteins [BR:aml04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    100483919 (KRAS)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 MeaB FeoB_N G-alpha ATP_bind_1 Septin NPR1_interact AAA_25
Other DBs
NCBI-GeneID: 100483919
NCBI-ProteinID: XP_034502440
Ensembl: ENSAMEG00000007529
LinkDB
Position
16
AA seq 189 aa
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKINKEEKTPGC
VKIKKCIVM
NT seq 570 nt   +upstreamnt  +downstreamnt
atgactgaatataaacttgtggtagttggagctggtggcgtaggcaagagtgccttgacg
atacagctaattcagaatcactttgtggatgaatatgatcctacaatagaggattcctac
aggaaacaagtagtaattgatggagaaacctgtctcttggatattctcgacacagcaggt
caagaggagtacagtgcaatgagggaccagtacatgaggactggggagggctttctttgt
gtatttgccataaataatactaaatcatttgaagatattcaccattatagagaacaaata
aaaagagttaaagactctgaagatgtacctatggtcctagtaggaaataaatgtgatttg
ccttctagaacagtagacacaaaacaggctcaggacttagcaagaagttatggaattcct
tttattgaaacatcagcaaagacaagacagagagtggaggatgctttttatacattggtg
agagagatccgacaatacagattgaaaaaaatcaacaaagaagaaaagactcctggctgt
gtgaaaattaaaaaatgcattgtaatgtaa

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