Bubalus bubalis (water buffalo): 102398103 Help Entry 102398103         CDS       T05912                                  Symbol EGFR Name (RefSeq) epidermal growth factor receptor   KO K04361   epidermal growth factor receptor [EC:2.7.10.1] Organism bbub  Bubalus bubalis (water buffalo) Pathway bbub01521   EGFR tyrosine kinase inhibitor resistance bbub01522   Endocrine resistance bbub03272   Virion - Hepatitis viruses bbub04010   MAPK signaling pathway bbub04012   ErbB signaling pathway bbub04014   Ras signaling pathway bbub04015   Rap1 signaling pathway bbub04020   Calcium signaling pathway bbub04066   HIF-1 signaling pathway bbub04068   FoxO signaling pathway bbub04072   Phospholipase D signaling pathway bbub04144   Endocytosis bbub04151   PI3K-Akt signaling pathway bbub04510   Focal adhesion bbub04520   Adherens junction bbub04540   Gap junction bbub04630   JAK-STAT signaling pathway bbub04810   Regulation of actin cytoskeleton bbub04912   GnRH signaling pathway bbub04915   Estrogen signaling pathway bbub04921   Oxytocin signaling pathway bbub04926   Relaxin signaling pathway bbub04928   Parathyroid hormone synthesis, secretion and action bbub04934   Cushing syndrome bbub05160   Hepatitis C bbub05163   Human cytomegalovirus infection bbub05165   Human papillomavirus infection bbub05171   Coronavirus disease - COVID-19 bbub05200   Pathways in cancer bbub05205   Proteoglycans in cancer bbub05206   MicroRNAs in cancer bbub05207   Chemical carcinogenesis - receptor activation bbub05208   Chemical carcinogenesis - reactive oxygen species bbub05210   Colorectal cancer bbub05212   Pancreatic cancer bbub05213   Endometrial cancer bbub05214   Glioma bbub05215   Prostate cancer bbub05218   Melanoma bbub05219   Bladder cancer bbub05223   Non-small cell lung cancer bbub05224   Breast cancer bbub05225   Hepatocellular carcinoma bbub05226   Gastric cancer bbub05230   Central carbon metabolism in cancer bbub05231   Choline metabolism in cancer bbub05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:bbub00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03272 Virion - Hepatitis viruses     102398103 (EGFR)  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     102398103 (EGFR)    04012 ErbB signaling pathway     102398103 (EGFR)    04014 Ras signaling pathway     102398103 (EGFR)    04015 Rap1 signaling pathway     102398103 (EGFR)    04630 JAK-STAT signaling pathway     102398103 (EGFR)    04066 HIF-1 signaling pathway     102398103 (EGFR)    04068 FoxO signaling pathway     102398103 (EGFR)    04020 Calcium signaling pathway     102398103 (EGFR)    04072 Phospholipase D signaling pathway     102398103 (EGFR)    04151 PI3K-Akt signaling pathway     102398103 (EGFR)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     102398103 (EGFR)   09144 Cellular community - eukaryotes    04510 Focal adhesion     102398103 (EGFR)    04520 Adherens junction     102398103 (EGFR)    04540 Gap junction     102398103 (EGFR)   09142 Cell motility    04810 Regulation of actin cytoskeleton     102398103 (EGFR)  09150 Organismal Systems   09152 Endocrine system    04912 GnRH signaling pathway     102398103 (EGFR)    04915 Estrogen signaling pathway     102398103 (EGFR)    04921 Oxytocin signaling pathway     102398103 (EGFR)    04926 Relaxin signaling pathway     102398103 (EGFR)    04928 Parathyroid hormone synthesis, secretion and action     102398103 (EGFR)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102398103 (EGFR)    05206 MicroRNAs in cancer     102398103 (EGFR)    05205 Proteoglycans in cancer     102398103 (EGFR)    05207 Chemical carcinogenesis - receptor activation     102398103 (EGFR)    05208 Chemical carcinogenesis - reactive oxygen species     102398103 (EGFR)    05230 Central carbon metabolism in cancer     102398103 (EGFR)    05231 Choline metabolism in cancer     102398103 (EGFR)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102398103 (EGFR)   09162 Cancer: specific types    05210 Colorectal cancer     102398103 (EGFR)    05212 Pancreatic cancer     102398103 (EGFR)    05225 Hepatocellular carcinoma     102398103 (EGFR)    05226 Gastric cancer     102398103 (EGFR)    05214 Glioma     102398103 (EGFR)    05218 Melanoma     102398103 (EGFR)    05219 Bladder cancer     102398103 (EGFR)    05215 Prostate cancer     102398103 (EGFR)    05213 Endometrial cancer     102398103 (EGFR)    05224 Breast cancer     102398103 (EGFR)    05223 Non-small cell lung cancer     102398103 (EGFR)   09172 Infectious disease: viral    05160 Hepatitis C     102398103 (EGFR)    05171 Coronavirus disease - COVID-19     102398103 (EGFR)    05163 Human cytomegalovirus infection     102398103 (EGFR)    05165 Human papillomavirus infection     102398103 (EGFR)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     102398103 (EGFR)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102398103 (EGFR)    01522 Endocrine resistance     102398103 (EGFR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bbub01001]     102398103 (EGFR)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:bbub04147]     102398103 (EGFR) Enzymes [BR:bbub01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      102398103 (EGFR) Protein kinases [BR:bbub01001]  Receptor tyrosine kinases (RTK)   EGFR family [OT]    102398103 (EGFR) Exosome [BR:bbub04147]  Exosomal proteins   Exosomal proteins of colorectal cancer cells    102398103 (EGFR)   Exosomal proteins of pancreatic cancer cells    102398103 (EGFR)   Exosomal proteins of bladder cancer cells    102398103 (EGFR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Kinase-like Borrelia_P83 ABC1 Haspin_kinase Motif Other DBs NCBI-GeneID:  102398103 NCBI-ProteinID:  XP_025128865 LinkDB All DBs Position 21:complement(928575..1146920) Genome browser AA seq 1208 aa AA seqDB search MRLSGAGRAALLVLLAAHFQASLALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV VLGNLEITYMQSSYNLSFLKTIQEVAGYVLIALNTVEKIPLENLQIIRGNVLYENTHALA VLSNYGANKTGLRELPLRNLQEILQGAVRFSNNPVLCNVETIQWRDIVNPDFLSNMTGDF QNQQGNCPKCDPACLNRSCWGAGEENCQKLTKIICAQQCSGRCRGRSPSDCCHNQCAAGC TGPRESDCLVCRRFRDEATCKDTCPPLMLYDPTTYEMKVNPLGKYSFGATCVKKCPRNYV VTDHGSCVRACSSDSQEVEEDGVRKCKKCDGPCGKVCNGIGIGEFKDTLSINATNIKHFR NCTSISGDLHILPVAFRGDSFTRTAPLDPKELDILRTVKEITGFLLIQAWPENRTDLHAF ENLEIIRGRTKQHGQFSLAVVGLDITSLGLRSLKEISDGDVIISGNRNLCYADTIRWKKL FGTSTQKTKILNNRSEKQCKATGHICHPLCSSEGCWGPGPKYCMSCQNFSRGKECVGKCN ILEGEPREFVENSECVQCHPECLPQAMNVTCTGRGPGNCVKCAHYIDGPHCVKTCPAGVA GENGTLIWKFADASHVCHLCHPNCTYGCEGPGLEGCPPNGPKIPSIATGIVGGLLLVLVL ALSVGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKVKVLGS GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY GVTVWELMTFGSKPYDGIPASEISTVLEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK FRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLVPQ QGFFHSPATSRTPLLSSLSTSSNTPTVTCVDRNGSYPLKEDSFLQRYSSDPTGALIEDSM DDAFLPVPEYVNQSVPKRPAGSVQNPVYHNQPLYPAPGRDPQYQNSRSNAVDNPEYLNTT HPACINGVLDGPALWAQKGSHQISLDNPDYQQAFFPKEAKSNGIFKGPAAENAEYLRAAP AGSDFTGA NT seq 3627 nt NT seq  +upstreamnt  +downstreamnt atgcgactctccggggcgggccgcgcggcgctcctggtgctgctggcagcgcacttccag gcgagtctagcgctggaggagaagaaagtttgccaagggacaagtaacaagctcacccag ttgggcacttttgaagaccactttctgagcctacagaggatgttcaacaactgtgaggtg gtccttgggaatttggaaattacctacatgcagagtagttacaacctttcttttctcaag accatccaggaggttgccggctatgtactcattgccctcaacacagtggagaagattccg ttggaaaacctgcagatcatccgaggaaatgtgctttatgaaaacacccatgccttagcg gtcttatccaactatggagcaaacaaaaccggactgagggagctgcccttgagaaactta caggaaattctgcaaggtgccgtgcgattcagcaacaaccctgtcctctgcaacgtggag accatccagtggcgggacatcgtcaaccctgattttctaagcaacatgacaggggacttt cagaaccagcagggcaactgcccaaagtgtgatccagcctgtctcaacagaagctgctgg ggtgccggggaggagaactgccagaaattgaccaagatcatctgtgcccagcagtgttcc gggcgctgccgcggcaggtcccccagcgactgctgccacaaccagtgtgccgctggctgc acggggccacgggagagcgactgcctggtctgccgcaggttccgtgatgaagccacctgc aaggacacgtgtccgccactcatgctctatgaccctaccacctacgaaatgaaggtcaac ccgctggggaagtacagctttggtgccacctgtgtcaagaagtgtccccgtaactacgtg gtgacagaccacggctcctgcgtccgcgcctgcagctctgacagccaggaggtagaggag gatggcgtccgcaagtgtaaaaagtgtgacgggccttgtggcaaagtttgtaacggaata ggaatcggtgagtttaaagacacactttccataaatgctacaaacattaaacacttcaga aactgcacatccatcagtggagatcttcatatcctgccagtagcatttaggggtgactcc ttcacacgtactgcacctctggacccaaaagaactggacattctaagaactgtaaaagaa ataacagggtttttgctgattcaggcctggcctgaaaataggactgacctccatgctttt gagaacctggaaatcatacgtggcagaacaaagcaacatggccagttttctcttgcggtt gtcggcctggatatcacatctttgggattacgctccctcaaggagataagtgatggtgat gtgataatttcaggaaatcgaaacttgtgctatgcagatacgatacgctggaaaaaactt tttgggacctcaactcagaaaaccaaaattttaaacaacaggagtgaaaaacagtgcaag gccacaggccacatctgtcacccgctgtgctcatcagagggctgctggggacctggaccc aaatactgcatgtcctgtcagaacttcagtcgtggcaaggagtgtgtgggaaagtgcaac attctagagggagagcccagagaattcgtggagaactccgagtgtgtgcagtgccatcca gaatgcctgccccaggccatgaacgtgacctgcactggacgcggaccaggcaactgtgta aagtgtgcccactacattgatggccctcactgcgtcaagacctgccctgctggagtcgcg ggagagaatggcaccctgatctggaagtttgcagatgccagtcacgtgtgccacctgtgc caccccaactgcacctatggctgtgaagggccaggtctcgaaggctgtccaccaaatggg cccaagatcccgtccattgccacgggcatcgtgggcggcctgctgctggtgttggtgctg gccctgagcgtcggcctcttcatgcgcaggcgccacatcgtgcgcaagcgcacactgcgc cggctgctgcaggagcgtgagctcgtggagcctctgacgcccagcggagaagctcccaac caagctctcttgaggatcctaaaggaaacagaattcaagaaggtcaaggtgctgggctca ggagcgttcggcaccgtgtacaagggactctggatcccagaaggcgagaaggttaaaatt cctgtagctatcaaggaattaagagaagccacatctccaaaagccaacaaggaaattctt gatgaggcctacgtgatggccagtgtggacaacccccatgtgtgccgcctcctgggcatc tgcctgacctccaccgtgcagctcatcacacagctcatgcccttcggctgcctgctggac tacgtccgcgagcacaaggacaacatcggctcccagtacctgctcaactggtgtgtgcag atcgcaaagggcatgaattacctggaagaccggcgcttggtgcatagggacctggcggcc aggaacgtgctggtgaagacgccacagcacgtgaagatcacagacttcgggctggccaag ctgctgggtgccgaggagaaggagtatcacgcagaaggaggcaaggtccctatcaaatgg atggctttggaatcaattttacaccgaatttatacccatcagagtgatgtctggagctat ggagtcactgtttgggagttgatgacctttggatccaagccttacgatggaatccctgcg agtgagatctcgactgtcctggagaaaggagagcgcctcccgcagccacccatctgcacc atcgacgtctacatgatcatggtcaagtgctggatgatagatgcagacagtcgcccaaag ttccgtgagttgatccttgaattctccaagatggcccgagacccccagcgctaccttgtc atccagggggacgagagaatgcatttgccaagccccacggactccaacttttaccgcgcc ctgatggatgaggaggacatggaggacgttgtggatgctgacgagtacctcgtcccccag cagggcttcttccacagccccgccacctcccggacaccgctcctcagctccctgagcacc tccagcaacactcccactgtgacttgcgttgatagaaatgggagctaccctctcaaggaa gacagtttcttgcagcgctacagctcagaccccactggtgccctcatcgaggacagcatg gacgatgctttcctcccagtacccgaatatgtaaaccagtctgttcccaaaagacccgca ggctctgtccagaaccctgtctatcacaatcagcctctatatccagctcctggcagagac cctcaataccaaaattcacgcagcaacgccgtggacaaccctgagtatctcaacaccacc catcctgcctgtatcaatggtgtactcgatggccctgccctctgggctcagaagggcagt caccaaattagcctagacaaccctgactaccagcaggccttctttcccaaggaagccaag tcgaatggcatctttaaggggcctgcagctgaaaatgcagagtacctgcgggcagcacca gcaggcagtgactttactggggcctga

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