KEGG   DRUG: Testosterone
Entry
D00075                      Drug                                   

Name
Testosterone (JAN/USP);
Androderm (TN);
Androgel (TN);
Axiron (TN);
Striant (TN);
Testim (TN)
Product
  Generic
TESTOSTERONE (Actavis Pharma), TESTOSTERONE (Actavis Pharma), TESTOSTERONE (Actavis Pharma), TESTOSTERONE (Actavis Pharma), TESTOSTERONE (Actavis Pharma), TESTOSTERONE (Alembic Pharmaceuticals), TESTOSTERONE (Alembic Pharmaceuticals), TESTOSTERONE (Aleor Dermaceuticals Limited), TESTOSTERONE (Aleor Dermaceuticals Limited), TESTOSTERONE (Amneal Pharmaceuticals NY LLC), TESTOSTERONE (Bryant Ranch Prepack), TESTOSTERONE (Bryant Ranch Prepack), TESTOSTERONE (Bryant Ranch Prepack), TESTOSTERONE (Bryant Ranch Prepack), TESTOSTERONE (Cipla USA), TESTOSTERONE (Dash Pharmaceuticals LLC), TESTOSTERONE (Dr. Reddy's Laboratories), TESTOPEL (Endo Pharmaceuticals), TESTOSTERONE (Lupin Pharmaceuticals), TESTOSTERONE (Lupin Pharmaceuticals), TESTOSTERONE (Northstar RxLLC), TESTOSTERONE (Padagis Israel Pharmaceuticals), TESTOSTERONE (Padagis Israel Pharmaceuticals), TESTOSTERONE (Par Pharmaceutical), TESTOSTERONE (Par Pharmaceutical), TESTOSTERONE (TWi Pharmaceuticals), TESTOSTERONE (Upsher-Smith Laboratories), TESTOSTERONE (Xiromed), TESTOSTERONE (Zydus Pharmaceuticals USA), TESTOSTERONE GEL, 1% (Encube Ethicals Private Limited)
Formula
C19H28O2
Exact mass
288.2089
Mol weight
288.4244
Structure
Simcomp
Class
Hormonal agent
 DG01590  Androgen receptor agonist
 DG02006  Testosterone
Remark
Same as: C00535
ATC code: G03BA03
Chemical structure group: DG00460
Product (DG00460): D00075<US> D00957<US> D00958<JP/US> D06087<US>
Efficacy
Replenisher (androgen), Androgen receptor agonist
  Disease
Hypogonadotropic hypogonadism [DS:H00255]
Target
NR3C4 (AR) [HSA:367] [KO:K08557]
  Pathway
hsa04114  Oocyte meiosis
Interaction
Structure map
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03B ANDROGENS
    G03BA 3-oxoandrosten (4) derivatives
     G03BA03 Testosterone
      D00075  Testosterone (JAN/USP) <US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Androgens
   Testosterone
    D00075  Testosterone (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for  urogenital organs and anus
  31 Other drugs for  urogenital organs and anus
   D00075  Testosterone (JAN/USP)
 Agents for integumentary system
  61 Other agents for integumentary system
   D00075  Testosterone (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Testosterone
    D00075  Testosterone (JAN/USP)
Drug groups [BR:br08330]
 Hormonal agent
  DG01590  Androgen receptor agonist
   DG00460  Testosterone
    D00075  Testosterone
  DG02006  Testosterone
   DG00460  Testosterone
    D00075  Testosterone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C4 (AR)
     D00075  Testosterone (JAN/USP) <US>
Drug groups [BR:br08330]
 Hormonal agent
  DG01590  Androgen receptor agonist
   DG00460  Testosterone
  DG02006  Testosterone
   DG00460  Testosterone
Other DBs
CAS: 58-22-0
PubChem: 7847143
ChEBI: 17347
ChEMBL: CHEMBL386630 CHEMBL67934
DrugBank: DB00624
PDB-CCD: TES[PDBj]
LigandBox: D00075
NIKKAJI: J4.590J
LinkDB
KCF data

ATOM        21
            1   C1x C    28.5514  -18.0276
            2   C5x C    28.5514  -19.4309
            3   C2x C    29.7441  -20.1325
            4   C2y C    31.0070  -19.4309
            5   C1z C    31.0070  -18.0276
            6   C1x C    29.7441  -17.3260
            7   C1x C    32.1998  -20.1325
            8   C1x C    33.3925  -19.4309
            9   C1y C    33.3925  -18.0276
            10  C1y C    32.1998  -17.3260
            11  C1y C    34.6554  -17.3260
            12  C1z C    34.6554  -15.9228
            13  C1x C    33.3925  -15.2212
            14  C1x C    32.1998  -15.9228
            15  O5x O    27.3586  -20.1325
            16  C1a C    34.6554  -14.5195
            17  C1a C    31.0070  -16.6244
            18  C1x C    37.0803  -17.3260
            19  C1x C    37.0803  -15.9228
            20  C1y C    35.8678  -15.2228
            21  O1a O    35.8678  -13.8228
BOND        24
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17    2  15 2
            18   12  16 1 #Up
            19    5  17 1 #Up
            20   11  18 1
            21   18  19 1
            22   19  20 1
            23   12  20 1
            24   20  21 1 #Up

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