| Entry |
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| Name |
Etoposide (JP18/USP/INN);
Vepesid (TN) |
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| Product |
|
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| Generic |
|
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| Formula |
C29H32O13
|
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| Exact mass |
588.1843
|
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| Mol weight |
588.55
|
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| Structure |
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| Simcomp |
|
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| Class |
Antineoplastic
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
|
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| Remark |
| Therapeutic category: | 4240 |
| Product (DG00693): | D00125<JP/US> D04107<US> |
|
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| Efficacy |
Antineoplastic, Topoisomerase II inhibitor |
|---|
| Disease |
Testicular tumors [DS: H00023] Small cell lung cancer [DS: H00013] |
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| Comment |
podophyllotoxin [DR: D05529] derivative
|
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| Target |
|
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| Interaction |
|
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| Structure map |
| map07042 | Antineoplastics - agents from natural products |
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| Other map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
L01CB Podophyllotoxin derivatives
L01CB01 Etoposide
D00125 Etoposide (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
Molecular Target Inhibitors
Topoisomerase Inhibitors
Etoposide
D00125 Etoposide (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
424 Plant extract preparations
4240 Plant extract preparations
D00125 Etoposide (JP18/USP/INN)
Drug groups [BR:br08330]
Antineoplastic
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
DG00693 Etoposide
D00125 Etoposide
Target-based classification of drugs [BR:br08310]
Enzymes
Isomerases (EC5)
DNA topoisomerase
TOP2
D00125 Etoposide (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00125 Etoposide
Drug groups [BR:br08330]
Antineoplastic
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
DG00693 Etoposide
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 42
1 C8y C 27.7309 -19.0593
2 C8y C 27.7309 -20.4607
3 C8x C 28.9445 -21.1614
4 C8y C 30.1582 -20.4607
5 C8y C 30.1582 -19.0593
6 C8x C 28.9445 -18.3586
7 C1y C 31.3718 -21.1614
8 C1y C 32.5854 -20.4607
9 C1y C 32.5854 -19.0593
10 C1y C 31.3718 -18.3586
11 O2x O 26.3980 -18.6263
12 C1x C 25.5743 -19.7600
13 O2x O 26.3980 -20.8938
14 C7x C 33.9182 -20.8938
15 O7x O 34.7420 -19.7600
16 C1x C 33.9182 -18.6263
17 O6a O 34.3454 -22.2089
18 C8y C 31.3718 -22.5628
19 C8x C 30.1602 -23.2623
20 C8y C 30.1602 -24.6637
21 C8y C 31.3738 -25.3644
22 C8y C 32.5854 -24.6649
23 C8x C 32.5854 -23.2635
24 O2a O 28.9635 -25.3548
25 O2a O 33.7842 -25.3571
26 C1a C 34.9737 -24.6704
27 C1a C 27.7760 -24.6693
28 O1a O 31.3738 -26.7670
29 O2a O 31.3718 -16.9572
30 C1y C 30.1602 -16.2577
31 C1y C 30.1602 -14.8553
32 C1y C 28.9465 -14.1546
33 C1y C 27.7329 -14.8553
34 C1y C 27.7329 -16.2577
35 O2x O 28.9466 -16.9584
36 O2x O 26.5192 -14.1546
37 C1y C 25.3055 -14.8553
38 O2x O 25.3055 -16.2577
39 C1x C 26.5192 -16.9584
40 O1a O 28.9465 -12.7532
41 C1a C 24.0716 -14.1427
42 O1a O 31.3911 -14.1444
BOND 48
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 1 11 1
13 11 12 1
14 12 13 1
15 2 13 1
16 8 14 1
17 14 15 1
18 15 16 1
19 9 16 1
20 14 17 2
21 7 18 1 #Down
22 18 19 2
23 19 20 1
24 20 21 2
25 21 22 1
26 22 23 2
27 18 23 1
28 20 24 1
29 22 25 1
30 25 26 1
31 24 27 1
32 21 28 1
33 10 29 1 #Up
34 30 29 1 #Down
35 30 31 1
36 31 32 1
37 32 33 1
38 33 34 1
39 34 35 1
40 30 35 1
41 33 36 1
42 36 37 1
43 37 38 1
44 38 39 1
45 34 39 1
46 32 40 1 #Down
47 37 41 1 #Up
48 31 42 1 #Up
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