KEGG   DRUG: Buspirone hydrochloride
Entry
D00702                      Drug                                   
Name
Buspirone hydrochloride (USP);
Buspar (TN)
Product
  Generic
BUSPIRONE HCL (Advagen Pharma), BUSPIRONE HCL (Amneal Pharmaceuticals NY LLC), BUSPIRONE HCL (Bryant Ranch Prepack), BUSPIRONE HCL (Direct Rx), BUSPIRONE HCL (Direct_Rx), BUSPIRONE HCL (Direct_Rx), BUSPIRONE HCL (Proficient Rx LP), BUSPIRONE HCL (Proficient Rx LP), BUSPIRONE HCL (Quality Care Products), BUSPIRONE HCL (REMEDYREPACK), BUSPIRONE HCL (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (A-S Medication Solutions), BUSPIRONE HYDROCHLORIDE (Accord Healthcare), BUSPIRONE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), BUSPIRONE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), BUSPIRONE HYDROCHLORIDE (American Health Packaging), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUSPIRONE HYDROCHLORIDE (Asclemed USA), BUSPIRONE HYDROCHLORIDE (Aurobindo Pharma Limited), BUSPIRONE HYDROCHLORIDE (AvPAK), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Bryant Ranch Prepack), BUSPIRONE HYDROCHLORIDE (Cardinal Health 107), BUSPIRONE HYDROCHLORIDE (Cardinal Health 107), BUSPIRONE HYDROCHLORIDE (Cardinal Health 107), BUSPIRONE HYDROCHLORIDE (DIRECT RX), BUSPIRONE HYDROCHLORIDE (Denton Pharma), BUSPIRONE HYDROCHLORIDE (Direct Rx), BUSPIRONE HYDROCHLORIDE (Direct_Rx), BUSPIRONE HYDROCHLORIDE (EPIC PHARMA), BUSPIRONE HYDROCHLORIDE (Epic Pharma), BUSPIRONE HYDROCHLORIDE (Golden State Medical Supply), BUSPIRONE HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Major Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Major Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Mylan Institutional), BUSPIRONE HYDROCHLORIDE (Mylan Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (NCS HealthCare of KY), BUSPIRONE HYDROCHLORIDE (NCS HealthCare of KY), BUSPIRONE HYDROCHLORIDE (Nivagen Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Northwind Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Northwind Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Northwind Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (NuCare Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (NuCare Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (NuCare Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Oxford Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Preferred Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Preferred Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Preferred Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Proficient Rx LP), BUSPIRONE HYDROCHLORIDE (Proficient Rx LP), BUSPIRONE HYDROCHLORIDE (Proficient Rx LP), BUSPIRONE HYDROCHLORIDE (Proficient Rx LP), BUSPIRONE HYDROCHLORIDE (Proficient Rx LP), BUSPIRONE HYDROCHLORIDE (Proficient Rx LP), BUSPIRONE HYDROCHLORIDE (Proficient Rx LP), BUSPIRONE HYDROCHLORIDE (Proficient Rx LP), BUSPIRONE HYDROCHLORIDE (Quality Care Products), BUSPIRONE HYDROCHLORIDE (Quality Care Products), BUSPIRONE HYDROCHLORIDE (Quality Care Products), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (REMEDYREPACK), BUSPIRONE HYDROCHLORIDE (RPK Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (RPK Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (RPK Pharmaceuticals), BUSPIRONE HYDROCHLORIDE (Strides Pharma Science Limited), BUSPIRONE HYDROCHLORIDE (Strides Pharma), BUSPIRONE HYDROCHLORIDE (Teva Pharmaceuticals USA), BUSPIRONE HYDROCHLORIDE (Unichem Pharmaceuticals (USA)), BUSPIRONE HYDROCHLORIDE (Yiling Pharmaceutical), BUSPIRONE HYDROCHLORIDE (Zydus Lifesciences Limited), BUSPIRONE HYDROCHLORIDE (Zydus Pharmaceuticals USA)
Formula
C21H31N5O2. HCl
Exact mass
421.2245
Mol weight
421.9641
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01483  5-HT1A-receptor agonist
Remark
ATC code: N05BE01
Chemical structure group: DG00913
Product (DG00913): D00702<US>
Efficacy
Antianxiety, Minor tranquilizer, Serotonin 5-HT1A receptor agonist
  Disease
Generalized anxiety disorder [DS:H01662]
Comment
Buspirone derivative
Target
HTR1A [HSA:3350] [KO:K04153]
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07030  Anxiolytics
map07211  Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BE Azaspirodecanedione derivatives
     N05BE01 Buspirone
      D00702  Buspirone hydrochloride (USP) <US>
USP drug classification [BR:br08302]
 Anxiolytics
  Anxiolytics, Other
   Buspirone
    D00702  Buspirone hydrochloride (USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01483  5-HT1A-receptor agonist
   DG00913  Buspirone
    D00702  Buspirone hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00702  Buspirone hydrochloride (USP) <US>
   Serotonin
    HTR1A
     D00702  Buspirone hydrochloride (USP) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01483  5-HT1A-receptor agonist
   DG00913  Buspirone
Other DBs
CAS: 33386-08-2
PubChem: 7847767
ChEBI: 3224
LigandBox: D00702
NIKKAJI: J240.216E
LinkDB
KCF data

ATOM        29
            1   C1z C    30.6703  -12.8797
            2   C1x C    29.4326  -12.1783
            3   C1x C    30.6740  -14.2783
            4   C5x C    28.2471  -12.9204
            5   C5x C    29.4419  -15.0222
            6   N1y N    28.2509  -14.3190
            7   O5x O    27.0095  -12.2190
            8   O5x O    29.4440  -16.3742
            9   C1b C    27.0637  -15.0147
            10  C1b C    25.8261  -14.3132
            11  C1b C    24.6389  -15.0088
            12  C1b C    23.4014  -14.3074
            13  N1y N    22.2159  -15.0496
            14  C1x C    20.9783  -14.3482
            15  C1x C    22.2197  -16.4482
            16  C1x C    19.7911  -15.0437
            17  C1x C    20.9859  -17.1454
            18  N1y N    19.7949  -16.4424
            19  C8y C    18.5612  -17.1396
            20  N5x N    17.3702  -16.4366
            21  N5x N    18.5183  -18.5383
            22  C8x C    16.0664  -17.1338
            23  C8x C    17.3311  -19.2338
            24  C8x C    16.0935  -18.5308
            25  C1x C    32.0020  -13.3124
            26  C1x C    32.8245  -12.1795
            27  C1x C    32.0012  -11.0471
            28  C1x C    30.6698  -11.4802
            29  X   Cl   32.5491  -16.1055
BOND        31
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     4   7 2
            7     5   8 2
            8     6   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   18  19 1
            19   19  20 1
            20   19  21 2
            21   20  22 2
            22   21  23 1
            23   22  24 1
            24    5   6 1
            25   17  18 1
            26   23  24 2
            27    1  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31    1  28 1

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