KEGG   DRUG: Betamethasone sodium phosphate
Entry
D00972                      Drug                                   

Name
Betamethasone sodium phosphate (JP17/USP);
Celestone (TN)
Formula
C22H28FO8P. 2Na
Exact mass
516.1301
Mol weight
516.4046
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 1315 1329 2454
ATC code: A07EA04 C05AA05 D07AC01 D07XC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03
Chemical structure group: DG00095
Product (DG00095): D00244<JP> D00972<JP> D01357<JP/US> D01637<JP/US> D02032<JP>
Product (mixture): D04246<JP> D04446<JP/US>
Efficacy
Anti-inflammatory, Antirheumatic, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA04 Betamethasone
      D00972  Betamethasone sodium phosphate (JP17/USP) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA05 Betamethasone
      D00972  Betamethasone sodium phosphate (JP17/USP) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC01 Betamethasone
      D00972  Betamethasone sodium phosphate (JP17/USP) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XC Corticosteroids, potent, other combinations
     D07XC01 Betamethasone
      D00972  Betamethasone sodium phosphate (JP17/USP) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB01 Betamethasone
      D00972  Betamethasone sodium phosphate (JP17/USP) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD06 Betamethasone
      D00972  Betamethasone sodium phosphate (JP17/USP) <JP>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA04 Betamethasone
      D00972  Betamethasone sodium phosphate (JP17/USP) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA06 Betamethasone
      D00972  Betamethasone sodium phosphate (JP17/USP) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB04 Betamethasone
      D00972  Betamethasone sodium phosphate (JP17/USP) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA07 Betamethasone
      D00972  Betamethasone sodium phosphate (JP17/USP) <JP>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA03 Betamethasone
      D00972  Betamethasone sodium phosphate (JP17/USP) <JP>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Betamethasone
     D00972  Betamethasone sodium phosphate (JP17/USP)
   Glucocorticoids, High Potency
    Betamethasone
     D00972  Betamethasone sodium phosphate (JP17/USP)
   Glucocorticoids, Very High Potency
    Betamethasone
     D00972  Betamethasone sodium phosphate (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1315  Ophthalmic cortisones
     D00972  Betamethasone sodium phosphate (JP17/USP)
   132  Otic and nasal agents
    1329  Others
     D00972  Betamethasone sodium phosphate (JP17/USP)
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2454  Fluorinated adrenocorticotropic hormones
     D00972  Betamethasone sodium phosphate (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00972  Betamethasone sodium phosphate (JP17/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00972  Betamethasone sodium phosphate
Other DBs
CAS: 151-73-5
PubChem: 7848035
ChEBI: 3078
ChEMBL: CHEMBL1200762
DrugBank: DB00443
LigandBox: D00972
NIKKAJI: J7.409H
LinkDB
KCF data

ATOM        34
            1   C1y C    20.5509  -18.6771
            2   C1y C    19.3622  -19.3588
            3   C1z C    20.5626  -17.2961
            4   C1x C    22.9399  -18.7004
            5   C1z C    18.1794  -18.6655
            6   C1x C    19.3622  -20.7281
            7   C1z C    21.7686  -16.6144
            8   C1x C    19.3855  -16.6144
            9   C1a C    20.5567  -15.9269
            10  C1y C    22.9514  -17.3253
            11  C1z C    16.9908  -19.3471
            12  C1y C    18.1910  -17.2961
            13  X   F    18.1677  -20.0289
            14  C1x C    18.1677  -21.4098
            15  C5a C    21.7745  -15.2451
            16  O1a O    23.0913  -16.2589
            17  C1a C    24.2741  -17.2381
            18  C2y C    16.9849  -20.7222
            19  C2x C    15.8021  -18.6596
            20  C1a C    16.9791  -17.9662
            21  O1a O    17.0025  -16.6028
            22  C1b C    22.9573  -14.5575
            23  O5a O    20.5743  -14.5575
            24  C2x C    15.8021  -21.4040
            25  C2x C    14.6135  -19.3471
            26  O2b O    24.1401  -15.2334
            27  C5x C    14.6135  -20.7222
            28  P1b P    25.2763  -14.4585
            29  O5x O    13.4190  -21.3981
            30  O1c O    26.4534  -15.1461
            31  O1c O    26.4068  -13.6836 #-
            32  O1c O    24.5014  -13.3223 #-
            33  Z   Na   28.9880  -14.9538 #+
            34  Z   Na   28.9181  -18.1935 #+
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    5  13 1 #Down
            13    6  14 1
            14    7  15 1 #Up
            15    7  16 1 #Down
            16   10  17 1 #Up
            17   11  18 1
            18   11  19 1
            19   11  20 1 #Up
            20   12  21 1 #Up
            21   15  22 1
            22   15  23 2
            23   18  24 2
            24   19  25 2
            25   22  26 1
            26   24  27 1
            27   26  28 1
            28   27  29 2
            29   28  30 2
            30   28  31 1
            31   28  32 1
            32    7  10 1
            33    8  12 1
            34   14  18 1
            35   25  27 1

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