| Entry |
|
|---|
| Name |
Nifekalant hydrochloride (JAN);
MS 551;
Shinbit (TN) |
|---|
| Formula |
C19H27N5O5. HCl
|
|---|
| Exact mass |
441.1779
|
|---|
| Mol weight |
441.9091
|
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| Structure |
|
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| Class |
Cardiovascular agent
DG01653 Antiarrhythmics
DG01648 Class III antiarrhythmic agent
|
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| Remark |
| Therapeutic category: | 2129 |
|
|---|
| Efficacy |
Antiarrhythmic, Potassium channel blocker |
|---|
| Comment |
Class III antiarrhythmic agent
|
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| Target |
|
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| Interaction |
|
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| Structure map |
| map07232 | Potassium channel blocking and opening drugs |
|
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2129 Others
D01856 Nifekalant hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Potassium channels
KCND3
D01856 Nifekalant hydrochloride (JAN) <JP>
KCNH2
D01856 Nifekalant hydrochloride (JAN) <JP>
Inward rectifier channels (Kir)
KCNJ12
D01856 Nifekalant hydrochloride (JAN) <JP>
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 30
1 X Cl 27.8315 -15.0437
2 C8x C 9.0553 -13.9192
3 C8y C 9.0553 -12.5189
4 C8x C 10.2708 -11.8188
5 C8x C 11.4793 -12.5189
6 C8y C 11.4793 -13.9192
7 C8x C 10.2708 -14.6193
8 C1b C 12.6914 -14.6199
9 N1c N 16.3298 -13.9225
10 C1b C 17.5420 -14.6235
11 C1b C 18.7552 -13.9244
12 N1b N 19.9672 -14.6254
13 C8y C 21.1803 -13.9261
14 C8x C 21.1775 -12.5261
15 C8y C 22.3906 -11.8268
16 N4y N 23.6028 -12.5279
17 C8y C 23.6018 -13.9281
18 N4y N 22.3886 -14.6272
19 C1a C 22.3866 -16.0275
20 O5x O 24.8138 -14.6291
21 C1a C 24.8160 -11.8287
22 O5x O 22.3917 -10.4266
23 C1b C 15.1163 -14.6194
24 C1b C 13.9070 -13.9193
25 N2b N 7.8429 -11.8181 #+
26 O3a O 7.8438 -10.4179
27 O3a O 6.6301 -12.5176 #-
28 C1b C 16.3320 -12.5223
29 C1b C 17.5457 -11.8241
30 O1a O 17.5477 -10.4239
BOND 30
1 9 10 1
2 10 11 1
3 11 12 1
4 12 13 1
5 13 14 2
6 14 15 1
7 15 16 1
8 16 17 1
9 17 18 1
10 18 13 1
11 18 19 1
12 17 20 2
13 16 21 1
14 15 22 2
15 7 2 1
16 9 23 1
17 23 24 1
18 24 8 1
19 8 6 1
20 3 25 1
21 2 3 2
22 25 26 2
23 3 4 1
24 25 27 1
25 4 5 2
26 9 28 1
27 5 6 1
28 28 29 1
29 6 7 2
30 29 30 1
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