| Entry |
|
|---|
| Name |
Fonazine mesylate (USAN);
Dimetotiazine mesilate (JAN);
Banistyl (TN) |
|---|
| Formula |
C19H25N3O2S2. CH4SO3
|
|---|
| Exact mass |
487.1269
|
|---|
| Mol weight |
487.6564
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
|
|---|
| Remark |
| Therapeutic category: | 1149 |
| Product (DG00843): | D01902<JP> |
|
|---|
| Efficacy |
Antimigraine, Serotonin receptor antagonist, H1 receptor antagonist |
|---|
| Comment |
Phenothiazine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02C ANTIMIGRAINE PREPARATIONS
N02CX Other antimigraine preparations
N02CX05 Dimetotiazine
D01902 Fonazine mesylate (USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
114 Antipyretics and analgesics, anti-inflammatory agents
1149 Others
D01902 Fonazine mesylate (USAN); Dimetotiazine mesilate (JAN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00843 Dimetotiazine
D01902 Fonazine mesylate
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D01902 Fonazine mesylate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D01902 Fonazine mesylate (USAN) <JP>
Serotonin
HTR2
D01902 Fonazine mesylate (USAN) <JP>
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00843 Dimetotiazine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 31
1 S2x S 20.7043 -19.6995
2 N1y N 20.7043 -16.8964
3 C8y C 21.9139 -17.5972
4 C8y C 21.9080 -18.9987
5 C8x C 23.1187 -19.7046
6 C8x C 24.3354 -19.0091
7 C8y C 24.3415 -17.6076
8 C8x C 23.1307 -16.9017
9 C8y C 19.4876 -18.9987
10 C8y C 19.4876 -17.5972
11 C8x C 18.2739 -16.8964
12 C8x C 17.0601 -17.5972
13 C8x C 17.0601 -18.9987
14 C8x C 18.2739 -19.6995
15 C1b C 20.7062 -15.4949
16 C1c C 21.9209 -14.7957
17 C1a C 23.1338 -15.4979
18 N1c N 21.9226 -13.3941
19 C1a C 23.1372 -12.6948
20 C1a C 20.7097 -12.6918
21 S4a S 25.5565 -16.9131
22 N1c N 26.7726 -17.6220
23 O1d O 26.5300 -15.9600
24 O1d O 24.5700 -15.9600
25 C1a C 27.9556 -16.9455
26 C1a C 26.7671 -19.0397
27 S4a S 33.5466 -16.9222
28 O1d O 33.5302 -15.5676
29 O1d O 33.5068 -18.3236
30 C1a C 32.1452 -16.9222
31 O1d O 34.9479 -16.9222
BOND 32
1 1 4 1
2 9 10 2
3 10 11 1
4 11 12 2
5 12 13 1
6 13 14 2
7 14 9 1
8 3 2 1
9 2 15 1
10 3 4 2
11 15 16 1
12 4 5 1
13 5 6 2
14 16 17 1
15 16 18 1
16 6 7 1
17 18 19 1
18 7 8 2
19 18 20 1
20 8 3 1
21 2 10 1
22 9 1 1
23 7 21 1
24 21 22 1
25 21 23 2
26 21 24 2
27 22 25 1
28 22 26 1
29 27 28 2
30 27 29 2
31 27 30 1
32 27 31 1
|
|---|
