KEGG T01001: 3357

Homo sapiens (human): 3357

Entry

3357              CDS       T01001

Symbol

HTR2B, 5-HT(2B), 5-HT-2B, 5-HT2B

Name

(RefSeq) 5-hydroxytryptamine receptor 2B

K04157

5-hydroxytryptamine receptor 2

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04082

Neuroactive ligand signaling

hsa04540

Gap junction

hsa04726

Serotonergic synapse

hsa04750

Inflammatory mediator regulation of TRP channels

Network

nt06528 Calcium signaling
nt06544 Neuroactive ligand signaling

Element

N01640

GPCR-PLCB-ITPR signaling pathway

N01900

Serotonin-HTR2-GNAQ/11 signaling pathway

Drug target

Adatanserin hydrochloride:

D02767

Brolamfetamine:

D12707

Chlorpromazine (DG00867):

D00270 D00789<JP/US> D03274 D04034<JP> D09819

Cinitapride (DG01520):

D07700 D07701

Cyproheptadine (DG01109):

D02234<JP/US> D07765

Dimetotiazine (DG00843):

D01902<JP> D07854

Flibanserin:

D02577<US>

Glemanserin:

D04320

Iloperidone:

D02666<US>

Methysergide (DG00835):

D00681 D02357

Metrenperone:

D05015

Milsaperidone:

D13099

Mirtazapine (DG02838):

D00563<JP/US> D11056

Ocaperidone:

D02675

Olanzapine (DG00898):

D00454<JP/US> D06623<US>

Opipramol (DG00930):

D01477 D08297

Pelanserin hydrochloride:

D05395

Periciazine:

D01485<JP>

Pizotifen (DG00842):

D05523 D08397

Sergolexole maleate:

D05829

Setoperone:

D02686

Tiospirone hydrochloride:

D02688

Trazodone (DG00952):

D00820<JP/US> D08626

Tropanserin hydrochloride:

D06253

Xylamidine tosylate:

D06343

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3357 (HTR2B)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3357 (HTR2B)
   04082 Neuroactive ligand signaling
    3357 (HTR2B)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    3357 (HTR2B)
09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    3357 (HTR2B)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    3357 (HTR2B)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3357 (HTR2B)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Serotonin
    3357 (HTR2B)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srv 7tm_4 7TM_GPCR_Srx

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

2:complement(231108230..231125042)

AA seq 481 aa
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
V

NT seq 1446 nt +upstreamnt +downstreamnt
atggctctctcttacagagtgtctgaacttcaaagcacaattcctgagcacattttgcag
agcacctttgttcacgttatctcttctaactggtctggattacagacagaatcaatacca
gaggaaatgaaacagattgttgaggaacagggaaataaactgcactgggcagctcttctg
atactcatggtgataatacccacaattggtggaaatacccttgttattctggctgtttca
ctggagaagaagctgcagtatgctactaattactttctaatgtccttggcggtggctgat
ttgctggttggattgtttgtgatgccaattgccctcttgacaataatgtttgaggctatg
tggcccctcccacttgttctatgtcctgcctggttatttcttgacgttctcttttcaacc
gcatccatcatgcatctctgtgccatttcagtggatcgttacatagccatcaaaaagcca
atccaggccaatcaatataactcacgggctacagcattcatcaagattacagtggtgtgg
ttaatttcaataggcattgccattccagtccctattaaagggatagagactgatgtggac
aacccaaacaatatcacttgtgtgctgacaaaggaacgttttggcgatttcatgctcttt
ggctcactggctgccttcttcacacctcttgcaattatgattgtcacctactttctcact
atccatgctttacagaagaaggcttacttagtcaaaaacaagccacctcaacgcctaaca
tggttgactgtgtctacagttttccaaagggatgaaacaccttgctcgtcaccggaaaag
gtggcaatgctggatggttctcgaaaggacaaggctctgcccaactcaggtgatgaaaca
cttatgcgaagaacatccacaattgggaaaaagtcagtgcagaccatttccaacgaacag
agagcctcaaaggtcctagggattgtgtttttcctctttttgcttatgtggtgtcccttc
tttattacaaatataactttagttttatgtgattcctgtaaccaaactactctccaaatg
ctcctggagatatttgtgtggataggctatgtttcctcaggagtgaatcctttggtctac
accctcttcaataagacatttcgggatgcatttggccgatatatcacctgcaattaccgg
gccacaaagtcagtaaaaactctcagaaaacgctccagtaagatctacttccggaatcca
atggcagagaactctaagtttttcaagaaacatggaattcgaaatgggattaaccctgcc
atgtaccagagtccaatgaggctccgaagttcaaccattcagtcttcatcaatcattcta
ctagatacgcttctcctcactgaaaatgaaggtgacaaaactgaagagcaagttagttat
gtatag

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