KEGG   DRUG: Betamethasone benzoate
Entry
D02286                      Drug                                   

Name
Betamethasone benzoate (USP);
Uticort (TN)
Formula
C29H33FO6
Exact mass
496.2261
Mol weight
496.5671
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: A07EA04 C05AA05 D07AC01 D07XC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03
Chemical structure group: DG00095
Product (DG00095): D00244<JP> D00972<JP> D01357<JP/US> D01637<JP/US> D02032<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA04 Betamethasone
      D02286  Betamethasone benzoate (USP)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA05 Betamethasone
      D02286  Betamethasone benzoate (USP)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC01 Betamethasone
      D02286  Betamethasone benzoate (USP)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XC Corticosteroids, potent, other combinations
     D07XC01 Betamethasone
      D02286  Betamethasone benzoate (USP)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB01 Betamethasone
      D02286  Betamethasone benzoate (USP)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD06 Betamethasone
      D02286  Betamethasone benzoate (USP)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA04 Betamethasone
      D02286  Betamethasone benzoate (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA06 Betamethasone
      D02286  Betamethasone benzoate (USP)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB04 Betamethasone
      D02286  Betamethasone benzoate (USP)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA07 Betamethasone
      D02286  Betamethasone benzoate (USP)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA03 Betamethasone
      D02286  Betamethasone benzoate (USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D02286  Betamethasone benzoate (USP)
Other DBs
CAS: 22298-29-9
PubChem: 7849345
ChEMBL: CHEMBL1200376
DrugBank: DB00443
LigandBox: D02286
NIKKAJI: J11.413H
LinkDB
KCF data

ATOM        36
            1   C2x C    15.5339  -19.8143
            2   C5x C    15.5339  -21.1939
            3   C2x C    16.7287  -21.8837
            4   C2y C    17.9235  -21.1939
            5   C1z C    17.9235  -19.8143
            6   C2x C    16.7287  -19.1245
            7   C1x C    19.1182  -21.8837
            8   C1x C    20.3130  -21.1939
            9   C1y C    20.3130  -19.8143
            10  C1z C    19.1182  -19.1245
            11  C1y C    21.5077  -19.1245
            12  C1z C    21.5077  -17.7449
            13  C1x C    20.3130  -17.0551
            14  C1y C    19.1182  -17.7449
            15  C1x C    23.8973  -19.1245
            16  C1y C    23.8973  -17.7449
            17  C1z C    22.7024  -17.0551
            18  O5x O    14.3392  -21.8837
            19  C1a C    17.9252  -18.4347
            20  C1a C    21.5122  -16.3653
            21  C1a C    25.0047  -17.2364
            22  X   F    19.1208  -20.5041
            23  O1a O    17.9254  -17.0562
            24  C5a C    22.7078  -15.3256
            25  C1b C    21.5157  -14.6311
            26  O5a O    23.9052  -14.6403
            27  O1a O    20.3137  -15.3189
            28  O7a O    23.9035  -16.3653
            29  C7a C    25.6330  -16.3653
            30  O6a O    26.3228  -17.5601
            31  C8y C    26.3228  -15.1705
            32  C8x C    27.7024  -15.1705
            33  C8x C    28.3922  -13.9758
            34  C8x C    27.7024  -12.7811
            35  C8x C    26.3228  -12.7811
            36  C8x C    25.6330  -13.9758
BOND        40
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Up
            25   10  22 1 #Down
            26   14  23 1 #Up
            27   17  24 1 #Up
            28   24  25 1
            29   24  26 2
            30   25  27 1
            31   17  28 1 #Down
            32   28  29 1
            33   29  30 2
            34   29  31 1
            35   31  32 2
            36   32  33 1
            37   33  34 2
            38   34  35 1
            39   35  36 2
            40   31  36 1

» Japanese version   » Back

DBGET integrated database retrieval system