| Entry |
|
|---|
| Name |
Flindokalner (USAN/INN);
Maxipost (TN) |
|---|
| Formula |
C16H10ClF4NO2
|
|---|
| Exact mass |
359.0336
|
|---|
| Mol weight |
359.70
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Remark |
|
|---|
| Efficacy |
Neuroprotectant, Potassium channel modulator |
|---|
| Comment |
opener of large conductance, calcium-activated (maxi-K) K+ channels
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Brite |
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Potassium channels
KCNQ
D04192 Flindokalner (USAN/INN)
KCNMB1
D04192 Flindokalner (USAN/INN)
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 24
1 C8y C 16.1581 -14.1268
2 C8x C 16.1581 -15.5293
3 C8x C 17.3726 -16.2302
4 C8y C 18.5870 -15.5293
5 C8y C 18.5870 -14.1268
6 C8x C 17.3726 -13.4257
7 C1z C 19.9206 -15.9625
8 C5x C 20.7449 -14.8280
9 N1x N 19.9206 -13.6936
10 O5x O 22.1412 -14.8280
11 C1d C 14.9437 -13.4257
12 X F 13.7277 -12.7246
13 C8y C 19.9206 -17.3606
14 C8x C 18.7089 -18.0601
15 C8y C 18.7089 -19.4582
16 C8x C 19.9197 -20.1572
17 C8x C 21.1314 -19.4577
18 C8y C 21.1314 -18.0596
19 X F 21.2711 -16.3243
20 X F 15.6433 -12.2130
21 X F 14.2460 -14.6349
22 X Cl 17.5146 -20.1475
23 O2a O 22.3767 -17.3407
24 C1a C 23.5674 -18.0286
BOND 26
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 5 9 1
11 8 10 2
12 1 11 1
13 11 12 1
14 7 13 1
15 13 14 2
16 14 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 13 18 1
21 7 19 1 #Down
22 11 20 1
23 11 21 1
24 15 22 1
25 18 23 1
26 23 24 1
|
|---|
