KEGG   DRUG: Flindokalner
Entry
D04192                      Drug                                   

Name
Flindokalner (USAN/INN);
Maxipost (TN)
Formula
C16H10ClF4NO2
Exact mass
359.0336
Mol weight
359.7027
Structure
Simcomp
Remark
Same as: C13830
Efficacy
Neuroprotectant, Potassium channel modulator
Comment
opener of large conductance, calcium-activated (maxi-K) K+ channels
Target
KCNQ [HSA:3784 3785 3786 9132 56479] [KO:K04926 K04927 K04928 K04929 K04930]
KCNMB1 [HSA:3779] [KO:K04937]
  Pathway
hsa04270  Vascular smooth muscle contraction
hsa04725  Cholinergic synapse
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Potassium channels
    KCNQ
     D04192  Flindokalner (USAN/INN)
    KCNMB1
     D04192  Flindokalner (USAN/INN)
Other DBs
CAS: 187523-35-9
PubChem: 47206138
ChEBI: 34548
ChEMBL: CHEMBL266510
LigandBox: D04192
LinkDB
KCF data

ATOM        24
            1   C8y C    16.1581  -14.1268
            2   C8x C    16.1581  -15.5293
            3   C8x C    17.3726  -16.2302
            4   C8y C    18.5870  -15.5293
            5   C8y C    18.5870  -14.1268
            6   C8x C    17.3726  -13.4257
            7   C1z C    19.9206  -15.9625
            8   C5x C    20.7449  -14.8280
            9   N1x N    19.9206  -13.6936
            10  O5x O    22.1412  -14.8280
            11  C1d C    14.9437  -13.4257
            12  X   F    13.7277  -12.7246
            13  C8y C    19.9206  -17.3606
            14  C8x C    18.7089  -18.0601
            15  C8y C    18.7089  -19.4582
            16  C8x C    19.9197  -20.1572
            17  C8x C    21.1314  -19.4577
            18  C8y C    21.1314  -18.0596
            19  X   F    21.2711  -16.3243
            20  X   F    15.6433  -12.2130
            21  X   F    14.2460  -14.6349
            22  X   Cl   17.5146  -20.1475
            23  O2a O    22.3767  -17.3407
            24  C1a C    23.5674  -18.0286
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    8  10 2
            12    1  11 1
            13   11  12 1
            14    7  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   13  18 1
            21    7  19 1 #Down
            22   11  20 1
            23   11  21 1
            24   15  22 1
            25   18  23 1
            26   23  24 1

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