KEGG T01001: 3784

Homo sapiens (human): 3784

Entry

3784              CDS       T01001

Symbol

KCNQ1, ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, KVLQT1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, WRS

Name

(RefSeq) potassium voltage-gated channel subfamily Q member 1

K04926

potassium voltage-gated channel KQT-like subfamily member 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04261

Adrenergic signaling in cardiomyocytes

hsa04725

Cholinergic synapse

hsa04971

Gastric acid secretion

hsa04972

Pancreatic secretion

hsa04974

Protein digestion and absorption

hsa05110

Vibrio cholerae infection

Disease

H00713

Beckwith-Wiedemann syndrome

H00720

Long QT syndrome

H00725

Short QT syndrome

H00731

Atrial fibrillation

H02091

Jervell and Lange-Nielsen syndrome

Drug target

Ambasilide:

D09758

Amiodarone (DG00204):

D00636<JP/US> D02910

Azimilide dihydrochloride:

D03037

Bepridil (DG00333):

D00631<JP> D07520

Dronedarone (DG00207):

D02537 D03914<US>

Flindokalner:

D04192

Retigabine:

D09569

Terikalant:

D09757

Brite

KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    3784 (KCNQ1)
  09154 Digestive system
   04971 Gastric acid secretion
    3784 (KCNQ1)
   04972 Pancreatic secretion
    3784 (KCNQ1)
   04974 Protein digestion and absorption
    3784 (KCNQ1)
  09156 Nervous system
   04725 Cholinergic synapse
    3784 (KCNQ1)
09160 Human Diseases
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    3784 (KCNQ1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    3784 (KCNQ1)
Ion channels [BR:hsa04040]
Voltage-gated cation channels
  Potassium channel, voltage-gated (Kv)
   3784 (KCNQ1)

SSDB

Motif

Pfam:

Ion_trans KCNQ_channel Ion_trans_2 WDCP

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

11:2445008..2849105

AA seq 676 aa
MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPG
PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGW
KCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC
RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA
DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQR
QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK
KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM
RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD
VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT
QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLP
TYEQLTVPRRGPDEGS

NT seq 2031 nt +upstreamnt +downstreamnt
atggccgcggcctcctccccgcccagggccgagaggaagcgctggggttggggccgcctg
ccaggcgcccggcggggcagcgcgggcctggccaagaagtgccccttctcgctggagctg
gcggagggcggcccggcgggcggcgcgctctacgcgcccatcgcgcccggcgccccaggt
cccgcgccccctgcgtccccggccgcgcccgccgcgcccccagttgcctccgaccttggc
ccgcggccgccggtgagcctagacccgcgcgtctccatctacagcacgcgccgcccggtg
ttggcgcgcacccacgtccagggccgcgtctacaacttcctcgagcgtcccaccggctgg
aaatgcttcgtttaccacttcgccgtcttcctcatcgtcctggtctgcctcatcttcagc
gtgctgtccaccatcgagcagtatgccgccctggccacggggactctcttctggatggag
atcgtgctggtggtgttcttcgggacggagtacgtggtccgcctctggtccgccggctgc
cgcagcaagtacgtgggcctctgggggcggctgcgctttgcccggaagcccatttccatc
atcgacctcatcgtggtcgtggcctccatggtggtcctctgcgtgggctccaaggggcag
gtgtttgccacgtcggccatcaggggcatccgcttcctgcagatcctgaggatgctacac
gtcgaccgccagggaggcacctggaggctcctgggctccgtggtcttcatccaccgccag
gagctgataaccaccctgtacatcggcttcctgggcctcatcttctcctcgtactttgtg
tacctggctgagaaggacgcggtgaacgagtcaggccgcgtggagttcggcagctacgca
gatgcgctgtggtggggggtggtcacagtcaccaccatcggctatggggacaaggtgccc
cagacgtgggtcgggaagaccatcgcctcctgcttctctgtctttgccatctccttcttt
gcgctcccagcggggattcttggctcggggtttgccctgaaggtgcagcagaagcagagg
cagaagcacttcaaccggcagatcccggcggcagcctcactcattcagaccgcatggagg
tgctatgctgccgagaaccccgactcctccacctggaagatctacatccggaaggccccc
cggagccacactctgctgtcacccagccccaaacccaagaagtctgtggtggtaaagaaa
aaaaagttcaagctggacaaagacaatggggtgactcctggagagaagatgctcacagtc
ccccatatcacgtgcgaccccccagaagagcggcggctggaccacttctctgtcgacggc
tatgacagttctgtaaggaagagcccaacactgctggaagtgagcatgccccatttcatg
agaaccaacagcttcgccgaggacctggacctggaaggggagactctgctgacacccatc
acccacatctcacagctgcgggaacaccatcgggccaccattaaggtcattcgacgcatg
cagtactttgtggccaagaagaaattccagcaagcgcggaagccttacgatgtgcgggac
gtcattgagcagtactcgcagggccacctcaacctcatggtgcgcatcaaggagctgcag
aggaggctggaccagtccattgggaagccctcactgttcatctccgtctcagaaaagagc
aaggatcgcggcagcaacacgatcggcgcccgcctgaaccgagtagaagacaaggtgacg
cagctggaccagaggctggcactcatcaccgacatgcttcaccagctgctctccttgcac
ggtggcagcacccccggcagcggcggcccccccagagagggcggggcccacatcacccag
ccctgcggcagtggcggctccgtcgaccctgagctcttcctgcccagcaacaccctgccc
acctacgagcagctgaccgtgcccaggaggggccccgatgaggggtcctga

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