KEGG   DRUG: Fluorouracil sodium salt
Entry
D07974                      Drug                                   

Name
Fluorouracil sodium salt;
Fluorouracil (TN)
Formula
C4H3FN2O2. xNa
Structure
Simcomp
Class
Antineoplastic
 DG01958  Nucleic acid derivative, antineoplastic
  DG01935  Fluoropyrimidine antineoplastic
 DG01935  Fluoropyrimidine antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01935  Fluoropyrimidine antineoplastic
Metabolizing enzyme substrate
 DG02984  DPYD substrate
Remark
ATC code: L01BC02
Chemical structure group: DG00687
Product (DG00687): D00584<JP/US>
Efficacy
Antineoplastic, Antimetabolite
Target
TYMS [HSA:7298] [KO:K00560]
  Pathway
hsa00240  Pyrimidine metabolism
hsa00670  One carbon pool by folate
Metabolism
Enzyme: DPYD [HSA:1806]
Interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BC Pyrimidine analogues
     L01BC02 Fluorouracil
      D07974  Fluorouracil sodium salt
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    TYMS
     D07974  Fluorouracil sodium salt
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07974
Other DBs
PubChem: 96024669
LigandBox: D07974
LinkDB
KCF data

ATOM        10
            1   C8y C    26.3200  -15.4700
            2   C8y C    25.1300  -16.2400
            3   N4x N    27.5100  -16.2400
            4   O5x O    26.3200  -14.0700
            5   C8x C    25.1300  -17.5700
            6   X   F    23.8700  -15.4700
            7   C8y C    27.5100  -17.5700
            8   N4x N    26.3200  -18.2700
            9   O5x O    28.7700  -18.2700
            10  Z   Na   32.2000  -17.2200
BOND        9
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     5   8 1
            8     7   9 2
            9     7   8 1
BRACKET     1    30.9400  -18.0600   30.9400  -16.1000
            1    34.0900  -16.1000   34.0900  -18.0600
            1  x
 ORIGINAL  1   10
 REPEAT    1

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