Homo sapiens (human): 7298 Help Entry 7298              CDS       T01001                                  Symbol TYMS, DKCD, HST422, TMS, TS Name (RefSeq) thymidylate synthetase   KO K00560   thymidylate synthase [EC:2.1.1.45] Organism hsa  Homo sapiens (human) Pathway hsa00240   Pyrimidine metabolism hsa00670   One carbon pool by folate hsa01100   Metabolic pathways hsa01232   Nucleotide metabolism hsa01523   Antifolate resistance hsa04981   Folate transport and metabolism Module hsa_M00938   Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP Disease H00507   Dyskeratosis congenita Drug target Arfolitixorin (DG03254):  D11447 D12528 Capecitabine:  D01223<JP/US> Carmofur:  D01784 Doxifluridine:  D01309<JP> Floxuridine:  D04197<US> Fluorouracil (DG00687):  D00584<JP/US> D07974 Fosifloxuridine nafalbenamide:  D12388 Metesind glucuronate:  D04964 Pemetrexed (DG00682):  D03828<US> D06503<JP/US> D07472<US> D10596<JP/US> D11352<US> Plevitrexed:  D10803 Raltitrexed:  D01064 Tegafur:  D01244 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09104 Nucleotide metabolism    00240 Pyrimidine metabolism     7298 (TYMS)   09108 Metabolism of cofactors and vitamins    00670 One carbon pool by folate     7298 (TYMS)  09150 Organismal Systems   09154 Digestive system    04981 Folate transport and metabolism     7298 (TYMS)  09160 Human Diseases   09176 Drug resistance: antineoplastic    01523 Antifolate resistance     7298 (TYMS) Enzymes [BR:hsa01000]  2. Transferases   2.1  Transferring one-carbon groups    2.1.1  Methyltransferases     2.1.1.45  thymidylate synthase      7298 (TYMS) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Thymidylat_synt Motif Other DBs NCBI-GeneID:  7298 NCBI-ProteinID:  NP_001062 OMIM:  188350 HGNC:  12441 Ensembl:  ENSG00000176890 UniProt:  P04818 Q53Y97 Structure PDBPDBj LinkDB All DBs Position 18:657653..673578 Genome browser AA seq 313 aa AA seqDB search MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG YNPHPTIKMEMAV NT seq 942 nt NT seq  +upstreamnt  +downstreamnt atgcctgtggccggctcggagctgccgcgccggcccttgccccccgccgcacaggagcgg gacgccgagccgcgtccgccgcacggggagctgcagtacctggggcagatccaacacatc ctccgctgcggcgtcaggaaggacgaccgcacgggcaccggcaccctgtcggtattcggc atgcaggcgcgctacagcctgagagatgaattccctctgctgacaaccaaacgtgtgttc tggaagggtgttttggaggagttgctgtggtttatcaagggatccacaaatgctaaagag ctgtcttccaagggagtgaaaatctgggatgccaatggatcccgagactttttggacagc ctgggattctccaccagagaagaaggggacttgggcccagtttatggcttccagtggagg cattttggggcagaatacagagatatggaatcagattattcaggacagggagttgaccaa ctgcaaagagtgattgacaccatcaaaaccaaccctgacgacagaagaatcatcatgtgc gcttggaatccaagagatcttcctctgatggcgctgcctccatgccatgccctctgccag ttctatgtggtgaacagtgagctgtcctgccagctgtaccagagatcgggagacatgggc ctcggtgtgcctttcaacatcgccagctacgccctgctcacgtacatgattgcgcacatc acgggcctgaagccaggtgactttatacacactttgggagatgcacatatttacctgaat cacatcgagccactgaaaattcagcttcagcgagaacccagacctttcccaaagctcagg attcttcgaaaagttgagaaaattgatgacttcaaagctgaagactttcagattgaaggg tacaatccgcatccaactattaaaatggaaatggctgtttag

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