| Entry |
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| Name |
Valbenazine (USAN/INN) |
|---|
| Formula |
C24H38N2O4
|
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| Exact mass |
418.2832
|
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| Mol weight |
418.5695
|
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| Structure |
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| Class |
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| Remark |
| Product (DG02115): | D10999<JP/US> |
|
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| Efficacy |
Neuroleptic, Vesicular monoamine transporter inhibitor |
|---|
| Comment |
Treatment of hyperkinetic movement disorders
|
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| Target |
|
|---|
| Pathway |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP3A5 [HSA: 1577]; CYP2D6 [HSA: 1565]
|
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07X OTHER NERVOUS SYSTEM DRUGS
N07XX Other nervous system drugs
N07XX13 Valbenazine
D10675 Valbenazine (USAN/INN)
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG02115 Valbenazine
D10675 Valbenazine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02115 Valbenazine
D10675 Valbenazine
DG02925 CYP3A5 substrate
DG02115 Valbenazine
D10675 Valbenazine
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC18
SLC18A2 (VMAT2)
D10675 Valbenazine (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10675
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG02115 Valbenazine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02115 Valbenazine
DG02925 CYP3A5 substrate
DG02115 Valbenazine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 30
1 C8y C 14.9800 -18.2700
2 C8y C 14.9800 -19.6700
3 C8x C 16.1924 -20.3700
4 C8y C 17.4049 -19.6700
5 C8y C 17.4049 -18.2700
6 C8x C 16.1924 -17.5700
7 O2a O 13.7676 -17.5700
8 C1a C 12.5551 -18.2700
9 C1a C 12.5551 -19.6700
10 O2a O 13.7676 -20.3700
11 C1x C 18.6173 -20.3700
12 C1x C 19.8297 -19.6700
13 N1y N 19.8297 -18.2700
14 C1y C 18.6173 -17.5700
15 C1x C 21.0422 -17.5700
16 C1y C 21.0422 -16.1700
17 C1y C 19.8297 -15.4700
18 C1x C 18.6173 -16.1700
19 C1a C 23.4670 -17.5700
20 C1c C 23.4670 -16.1700
21 C1b C 22.2546 -15.4700
22 O7a O 19.8297 -14.0700
23 C7a C 18.6173 -13.3700
24 C1c C 17.4049 -14.0700
25 N1a N 17.4049 -15.4700
26 C1c C 16.1925 -13.3700
27 C1a C 14.9800 -14.0700
28 C1a C 16.1925 -11.9700
29 C1a C 24.6794 -15.4700
30 O6a O 18.6173 -11.9700
BOND 32
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 1 7 1
8 7 8 1
9 9 10 1
10 2 10 1
11 4 11 1
12 11 12 1
13 12 13 1
14 13 14 1
15 5 14 1
16 13 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 14 18 1
21 19 20 1
22 20 21 1
23 16 21 1 #Down
24 22 23 1
25 23 24 1
26 17 22 1 #Up
27 24 25 1 #Up
28 24 26 1
29 26 27 1
30 26 28 1
31 20 29 1
32 23 30 2
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