KEGG   DISEASE: Melioidosis
Entry
H00317                      Disease                                
Name
Melioidosis
Description
Melioidosis (MD) is an infection caused by the gram-negative soil-dwelling bacillus Burkholderia pseudomallei. It predominantly affects people in regular contact with soil and water and is endemic in areas of Southeast Asia and Northern Australia. There are many possible disease manifestations including melioidosis septic shock, pneumonia, and hepatic and splenic abscesses.
Category
Bacterial infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Other bacterial diseases
   1C42  Melioidosis
    H00317  Melioidosis
Pathway-based classification of diseases [BR:br08402]
 Immune system
  nt06517  TLR signaling
   H00317  Melioidosis
Genome-based classification of infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by beta proteobacteria
   H00317  Melioidosis
Pathway
hsa04620  Toll-like receptor signaling pathway
Network
nt06517 TLR signaling
Gene
TLR5 (resistance) [HSA:7100] [KO:K10168]
Pathogen
Burkholderia pseudomallei [GN:bps bpm bpl bpd bpr bpse bpz bpq]
Other DBs
ICD-11: 1C42
ICD-10: A24.1 A24.2 A24.3 A24.4
MeSH: D008554
OMIM: 615557
Reference
  Authors
Limmathurotsakul D, Peacock SJ
  Title
Melioidosis: a clinical overview.
  Journal
Br Med Bull 99:125-39 (2011)
DOI:10.1093/bmb/ldr007
Reference
  Authors
Wiersinga WJ, van der Poll T, White NJ, Day NP, Peacock SJ
  Title
Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei.
  Journal
Nat Rev Microbiol 4:272-82 (2006)
DOI:10.1038/nrmicro1385
Reference
PMID:23447684 (TLR5)
  Authors
West TE, Chantratita N, Chierakul W, Limmathurotsakul D, Wuthiekanun V, Myers ND, Emond MJ, Wurfel MM, Hawn TR, Peacock SJ, Skerrett SJ
  Title
Impaired TLR5 functionality is associated with survival in melioidosis.
  Journal
J Immunol 190:3373-9 (2013)
DOI:10.4049/jimmunol.1202974
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