KEGG   ENZYME: 1.1.1.277
Entry
EC 1.1.1.277                Enzyme                                 
Name
3beta-hydroxy-5beta-steroid dehydrogenase;
3beta-hydroxysteroid 5beta-oxidoreductase;
3beta-hydroxysteroid 5beta-progesterone oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase
Reaction(IUBMB)
3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + NADPH + H+ [RN:R06166]
Reaction(KEGG)
R06166
Substrate
3beta-hydroxy-5beta-pregnane-20-one [CPD:C11825];
NADP+ [CPD:C00006]
Product
5beta-pregnan-3,20-dione;
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.277 created 2003
Reference
1
  Authors
Stuhlemmer, U. and Kreis, W.
  Title
Cardenolide formation and activity of pregnane-modifying enzymes in cell suspension cultures, shoot cultures and leaves of Digitalis lanata.
  Journal
Plant Physiol 34:85-91 (1996)
Reference
2
  Authors
Seitz, H.U. and Gaertner, D.E.
  Title
Enzymes in cardenolide-accumulating shoot cultures of Digitalis purpurea.
  Journal
Plant Cell 38:337-344 (1994)
Reference
3
  Authors
Lindemann, P. and Luckner, M.
  Title
Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata.
  Journal
Phytochemistry 46:507-513 (1997)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.277
IUBMB Enzyme Nomenclature: 1.1.1.277
ExPASy - ENZYME nomenclature database: 1.1.1.277
BRENDA, the Enzyme Database: 1.1.1.277
CAS: 162731-81-9
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