Entry |
|
Name |
3beta-hydroxy-5beta-steroid dehydrogenase;
3beta-hydroxysteroid 5beta-oxidoreductase;
3beta-hydroxysteroid 5beta-progesterone oxidoreductase
|
Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase
|
Reaction(IUBMB) |
3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + NADPH + H+ [RN: R06166]
|
Reaction(KEGG) |
|
Substrate |
3beta-hydroxy-5beta-pregnane-20-one [CPD: C11825];
NADP+ [CPD: C00006]
|
Product |
5beta-pregnan-3,20-dione;
NADPH [CPD: C00005];
H+ [CPD: C00080]
|
History |
EC 1.1.1.277 created 2003
|
Reference |
1 |
Authors |
Stuhlemmer, U. and Kreis, W. |
Title |
Cardenolide formation and activity of pregnane-modifying enzymes in cell suspension cultures, shoot cultures and leaves of Digitalis lanata. |
Journal |
Plant Physiol 34:85-91 (1996) |
Reference |
2 |
Authors |
Seitz, H.U. and Gaertner, D.E. |
Title |
Enzymes in cardenolide-accumulating shoot cultures of Digitalis purpurea. |
Journal |
Plant Cell 38:337-344 (1994) |
Reference |
3 |
Authors |
Lindemann, P. and Luckner, M. |
Title |
Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata. |
Journal |
Phytochemistry 46:507-513 (1997) |
Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.277 |
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LinkDB |
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