KEGG   ENZYME: 1.1.1.287
Entry
EC 1.1.1.287                Enzyme                                 

Name
D-arabinitol dehydrogenase (NADP+);
NADP+-dependent D-arabitol dehydrogenase;
ARD1p;
D-arabitol dehydrogenase 1
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-arabinitol:NADP+ oxidoreductase
Reaction(IUBMB)
(1) D-arabinitol + NADP+ = D-xylulose + NADPH + H+ [RN:R07143];
(2) D-arabinitol + NADP+ = D-ribulose + NADPH + H+ [RN:R07144]
Reaction(KEGG)
R07143 R07144
Substrate
D-arabinitol [CPD:C01904];
NADP+ [CPD:C00006]
Product
D-xylulose [CPD:C00310];
NADPH [CPD:C00005];
H+ [CPD:C00080];
D-ribulose [CPD:C00309]
Comment
The enzyme from the rust fungus Uromyces fabae can use D-arabinitol and D-mannitol as substrates in the forward direction and D-xylulose, D-ribulose and, to a lesser extent, D-fructose as substrates in the reverse direction. This enzyme carries out the reactions of both EC 1.1.1.11, D-arabinitol 4-dehydrogenase and EC 1.1.1.250, D-arabinitol 2-dehydrogenase, but unlike them, uses NADP+ rather than NAD+ as cofactor. D-Arabinitol is capable of quenching reactive oxygen species involved in defense reactions of the host plant.
History
EC 1.1.1.287 created 2005
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K17818  D-arabinitol dehydrogenase (NADP+)
Genes
BFO: BRAFLDRAFT_96053
CIN: 100181990 100184356
TCA: 656777 656956
DPA: 109543751
ATD: 109606193 109606521
BMOR: 732960
BMAN: 114244156
DPL: KGM_208136
PMAC: 106716118
PRAP: 111000494
HAW: 110382525
TNL: 113498593
EPA: 110231764
ADF: 107355656
AMIL: 114963647
DGT: 114536034
HMG: 100204180
MGR: MGG_01114
SSCK: SPSK_09459
MAW: MAC_06529
MAJ: MAA_07660
MBE: MBM_09044
ANI: AN0443.2
ANG: ANI_1_452014(An01g03480) ANI_1_552044(An05g02000)
ABE: ARB_06173
TVE: TRV_00619
PTE: PTT_18102
CNE: CNC06260
CNB: CNBC0940
TASA: A1Q1_00927
ABP: AGABI1DRAFT116829(AGABI1DRAFT_116829) AGABI1DRAFT46050(AGABI1DRAFT_46050)
ABV: AGABI2DRAFT145143(AGABI2DRAFT_145143) AGABI2DRAFT194619(AGABI2DRAFT_194619)
ART: Arth_1823
MRB: Mrub_2061
IAG: Igag_0313
 » show all
Reference
1  [PMID:15796718]
  Authors
Link T, Lohaus G, Heiser I, Mendgen K, Hahn M, Voegele RT.
  Title
Characterization of a novel NADP(+)-dependent D-arabitol dehydrogenase from the plant pathogen Uromyces fabae.
  Journal
Biochem J 389:289-95 (2005)
DOI:10.1042/BJ20050301
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.287
IUBMB Enzyme Nomenclature: 1.1.1.287
ExPASy - ENZYME nomenclature database: 1.1.1.287
BRENDA, the Enzyme Database: 1.1.1.287
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