KEGG   ENZYME: 1.1.1.324
Entry
EC 1.1.1.324                Enzyme                                 
Name
8-hydroxygeraniol dehydrogenase;
8-hydroxygeraniol oxidoreductase;
CYP76B10;
G10H;
CrG10H;
SmG10H;
acyclic monoterpene primary alcohol:NADP+ oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(6E)-8-hydroxygeraniol:NADP+ oxidoreductase
Reaction(IUBMB)
(6E)-8-hydroxygeraniol + 2 NADP+ = (6E)-8-oxogeranial + 2 NADPH + 2 H+ (overall reaction) [RN:R08499];
(1a) (6E)-8-hydroxygeraniol + NADP+ = (6E)-8-hydroxygeranial + NADPH + H+ [RN:R09926];
(1b) (6E)-8-hydroxygeraniol + NADP+ = (6E)-8-oxogeraniol + NADPH + H+  [RN:R09927];
(1c) (6E)-8-hydroxygeranial + NADP+ = (6E)-8-oxogeranial + NADPH + H+  [RN:R09928];
(1d) (6E)-8-oxogeraniol + NADP+ = (6E)-8-oxogeranial + NADPH + H+ [RN:R09929]
Reaction(KEGG)
Substrate
(6E)-8-hydroxygeraniol [CPD:C17621];
NADP+ [CPD:C00006];
(6E)-8-hydroxygeranial [CPD:C20222];
(6E)-8-oxogeraniol [CPD:C20223]
Product
(6E)-8-oxogeranial [CPD:C17622];
NADPH [CPD:C00005];
H+ [CPD:C00080];
(6E)-8-hydroxygeranial [CPD:C20222];
(6E)-8-oxogeraniol [CPD:C20223]
Comment
Contains Zn2+. The enzyme catalyses the oxidation of (6E)-8-hydroxygeraniol to (6E)-8-oxogeranial via either (6E)-8-hydroxygeranial or (6E)-8-oxogeraniol. Also acts on geraniol, nerol and citronellol. May be identical to EC 1.1.1.183 geraniol dehydrogenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the substrate rather than 10-hydroxygeraniol as used by references 1 and 2. See prenol nomenclature {iupac/misc/prenol#p1::Pr-1}.
History
EC 1.1.1.324 created 2012
Pathway
ec00902  Monoterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23232  8-hydroxygeraniol dehydrogenase
Genes
CIT102620668
CICCICLE_v10025755mg
PVY116129781 116131356 116133638 116143840 116143842 116146377
MINC123192061 123210469 123214839 123216740 123229782
TCC18611427 18611430
GRA105763514 105787742 105804130
GHI107925779 107940605 107940871 107943783 107947223 121209950
GAB108462294 108466633 108472514 108474204 108478314 108478630
HSYR120125616 120126736 120130479 120138239 120166901 120216530
DZI111288725 111291756 111291757 111311783 111311785 111317014
EGR104414101 104418344 104429416 104444737 104453744
GMX100809071 100816901
GSJ114409119 114409127
PVUPHAVU_002G144700g PHAVU_002G144800g
VRA106777707 106777709
VAR108320082
VUN114173303
VUM124828766 124845809 124845836
CCAJ109800810
APRC113868521 113868522 113868523
MTR11405461 11405463 11407843 11413451 11416510 11426262
TPRA123903767 123903768 123903771 123903772 123903777 123903778 123922700
CAM101510015 101510334 101510666 101511296
PSAT127076054 127118937 127118943
VVO131650205
ADU107480985 107487232 107487233 107487234 107487235 107487238
AIP107642290 107642291 107642292 107642293 107642295
AHF112747353 112747354 112747355 112747356 112747358 112791712 112799968 112799969 112799970 112799971
LANG109331771 109333059 109333060 109349124
PCIN129311339 129311340 129322367 129322368
QSAO6P43_025192 O6P43_025193 O6P43_025194 O6P43_033266 O6P43_033267 O6P43_033268 O6P43_033269
FVE101293136 101293434 101297378 101304719 101305018 105352586
RCN112170111 112170112 112170113 112170114 112173332 112187218 112190872 112190873 112197344 112197352 112197358 112197375
PPER109949827 109949828 18772394 18772397 18772399 18773163 18773263 18773431 18774545 18774850 18775537
PMUM103335223 103335236 103335246 103335256 103335267 103335277 103335288 103335298 103335314 103335323
PAVI110744604 110755099 110772149 110772150 110772154 110772158 110773133 110773134 110773136 110773885
PDUL117629578 117630081 117630082 117630719 117630894 117630895 117633135 117633136 117633137 117633139
MDM103415151 103416068 103446799 103448758 103448898 114821662
MSYL126584379 126587089 126605425 126605426 126620821 126621014 126623237 126623261
PXB103927900 103954148(SAD) 103954149 103954695 103954696
ZJU107425062 107425065 107425070 107425101 107425106 107425124 112492598 112492600 125418176
MNT21385909 21385910 21409376 21409442
CSAV115712847 115712849 115712850 115725521
CSV101222715(SECAD1)
CMO103484917
BHJ120073722
MCHA111005856
CMAX111478724
CMOS111453887
CPEP111803046
RCU8260964 8260966 8261810
JCU105641679 105641717 105641719 105641751
HBR110651640 110657190 110657297 110658829 110664407 110664408 110671751
MESC110604932 110604940 110608488 110608489 110608520 110608725 110627677 110627737 110629448 110629837 110629839 110630354
POP7455614 7463857 7465262 7475058 7475061 7488065
PEU105110689 105126043 105126294 105138196 105141572
PALZ118027679 118027681 118027682 118043831 118047063 118049851 118062493
JRE108984582 108986809 108986824 108994227 108999669 109003642 109003644 109003645 118349266
CILL122274147 122315253 122319192 122319194 122319195 122319298 122319299 122319300
CAVE132168433 132168436 132168441 132192152 132192286
QSU111999434 112003912 112006220 112006221 112006233 112021214
QLO115950210 115950657 115950658 115989470 115994249 115994453 115994455 115995349 115995451
TWL119986839 119995270 119998191 119999099 120012309
VVI100247559 100255907 100260964 100261642 100264687 100854583 100855108 100855415
VRI117907661 117918382 117918383 117918384 117918386 117919413 117919415
SLY101253340 101259903 101265396 104644298 543602
SPEN107003304 107003351 107003484 107004699 107004886
SOT102581654 102581912 102589424 102589753(drd-1) 102595339 102595669 102598492 102599810 102600145 102604900 107061631
SSTN125843529 125843531 125843532 125843885 125843886 125843887 125843893 125843898 125846084 125856828 125864456 125866244
SDUL129871570 129884974 129896857 129896882 129897360 129897376 129897438 129897470 129900419
CANN107849611 107850273 107850275 107850545 107850546 107851765
LBB132614181 132614242 132614243 132614851 132615022 132616209 132617051
NTA107772795(SAD4) 107773242 107773552
NSY104216597 104216598 104216600 104218512 104232065
NTO104089646 104103376 104108069 104114759 104114760
NAU109208903 109208905 109208906 109215604 109220179
INI109172721 109180300 109180302 109180303 109180304 109180305 109180306 109180307 109180308
ITR116012170 116012599 116012600 116012806 116012807 116013707 116013949 116013985 116014506 116021186 116025915
SIND105165970 105165971 105176369 105176370 105176372 105176373 105176374 105178229 105178286
OEU111373464 111373465 111373466 111376665 111376667 111385603
EGT105959003 105959013 105965126 105973276
SSPL121760094 121767408 121768607 121770429 121770797 121772668 121781933 121783176 121783317 121784594 121784595 121784596 121784598 121785111 121785252 121785270 121785680 121787553 121787593
SMIL131001627 131011140 131021871 131021872 131021874 131021875 131021877 131021878 131021920 131021921 131021922
APAN127242092 127248753 127248879 127256931 127256932 127258528
HAN110867821 110867822 110867824
ECAD122602767 122603005 122603360
LSV111883478
CCAV112510743
DCR108202765
CSIN114256186 114256196 114256206 114274899 114274964 114285850 114302967 114302972 114309783 114312840 114312846 114320821
RVL131304268 131304270 131304271 131304272 131304273 131304274 131331472 131331476 131331477
AEW130751817 130776906 130781834 130784599 130784965
BVG104895531 104895532
SOE110776508
CQI110682111 110695277 110713893 110725202
ATRI130820263 130820265
MOF131147218 131153794 131153802 131153831 131165296 131165303 131165312 131165318 131165323 131165331
NNU104588464
MING122067465 122070770 122070780 122070781 122083250
TSS122645617 122651163 122660519 122660520 122660521 122661590
PSOM113286661 113310981
ZOF121987083
MSIN131229328 131229329 131229330 131229333 131229335
 » show all
Reference
1  [PMID:1864846]
  Authors
Ikeda H, Esaki N, Nakai S, Hashimoto K, Uesato S, Soda K, Fujita T
  Title
Acyclic monoterpene primary alcohol:NADP+ oxidoreductase of Rauwolfia serpentina cells: the key enzyme in biosynthesis of monoterpene alcohols.
  Journal
J Biochem 109:341-7 (1991)
Reference
2  [PMID:7726550]
  Authors
Hallahan DL, West JM, Wallsgrove RM, Smiley DW, Dawson GW, Pickett JA, Hamilton JG
  Title
Purification and characterization of an acyclic monoterpene primary alcohol:NADP+ oxidoreductase from catmint (Nepeta racemosa).
  Journal
Arch Biochem Biophys 318:105-12 (1995)
DOI:10.1006/abbi.1995.1210
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.324
IUBMB Enzyme Nomenclature: 1.1.1.324
ExPASy - ENZYME nomenclature database: 1.1.1.324
BRENDA, the Enzyme Database: 1.1.1.324
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