KEGG   ENZYME: 1.1.1.349
Entry
EC 1.1.1.349                Enzyme                                 

Name
norsolorinic acid ketoreductase;
aflD (gene name);
nor-1 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(1'S)-averantin:NADP+ oxidoreductase
Reaction(IUBMB)
(1'S)-averantin + NADP+ = norsolorinic acid + NADPH + H+ [RN:R10309]
Reaction(KEGG)
R10309
Substrate
(1'S)-averantin [CPD:C20499];
NADP+ [CPD:C00006]
Product
norsolorinic acid [CPD:C20452];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
History
EC 1.1.1.349 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17644  norsolorinic acid ketoreductase
Genes
QSU: 111983631 111989788 112001206 112014326
NTE: NEUTE1DRAFT119162(NEUTE1DRAFT_119162) NEUTE1DRAFT142190(NEUTE1DRAFT_142190)
SMP: SMAC_00337 SMAC_12125
PAN: PODANSg8549 PODANSg8566
TTT: THITE_2089433 THITE_2147584
MGR: MGG_10274 MGG_10910
TMN: UCRPA7_6053 UCRPA7_7330 UCRPA7_8840
SSCK: SPSK_09534
FVR: FVEG_09885 FVEG_13322
FOX: FOXG_15212
CMT: CCM_08014
MBE: MBM_03300
ANI: AN7821.2
ANG: ANI_1_1648104(An12g03210) ANI_1_1730094(An11g02460) ANI_1_1984104(An12g06400) ANI_1_2226024(An02g01090)
 » show all
Reference
1  [PMID:8368836]
  Authors
Yabe K, Matsuyama Y, Ando Y, Nakajima H, Hamasaki T
  Title
Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin.
  Journal
Appl Environ Microbiol 59:2486-92 (1993)
DOI:10.1128/AEM.59.8.2486-2492.1993
Reference
2  [PMID:10584035]
  Authors
Zhou R, Linz JE
  Title
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus.
  Journal
Appl Environ Microbiol 65:5639-41 (1999)
DOI:10.1128/AEM.65.12.5639-5641.1999
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.349
IUBMB Enzyme Nomenclature: 1.1.1.349
ExPASy - ENZYME nomenclature database: 1.1.1.349
BRENDA, the Enzyme Database: 1.1.1.349
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