KEGG   ENZYME: 1.1.1.349
Entry
EC 1.1.1.349                Enzyme                                 
Name
norsolorinic acid ketoreductase;
aflD (gene name);
nor-1 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(1'S)-averantin:NADP+ oxidoreductase
Reaction(IUBMB)
(1'S)-averantin + NADP+ = norsolorinic acid + NADPH + H+ [RN:R10309]
Reaction(KEGG)
R10309
Substrate
(1'S)-averantin [CPD:C20499];
NADP+ [CPD:C00006]
Product
norsolorinic acid [CPD:C20452];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
History
EC 1.1.1.349 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17644  norsolorinic acid ketoreductase
Genes
PANPODANSg8566
PBELQC761_207200 QC761_207370(NOR1)
PPSDQC762_207200 QC762_207370(NOR1)
TTTTHITE_2147584
MGRMGG_10274
PPEIPpBr36_02616 PpBr36_09608
PGRIPgNI_02173 PgNI_10101
TMNUCRPA7_6053
FVNFVRRES_07755 FVRRES_10990
FVRFVEG_09885
FOXFOXG_15212
NHENECHADRAFT_19049 NECHADRAFT_44851 NECHADRAFT_94977
FFCNCS54_00901400 NCS54_00908600 NCS54_00917600 NCS54_00932700
FKRNCS57_00920500 NCS57_00926800 NCS57_00952200 NCS57_01357800
FMUJ7337_000075
TRETRIREDRAFT_103113 TRIREDRAFT_105884
TRRM419DRAFT_7213 M419DRAFT_88601
VALVDBG_02925 VDBG_06335
VDAVDAG_03485
CFJCFIO01_09694 CFIO01_11244
CLUPCLUP02_11195 CLUP02_13454 CLUP02_15568
CHIGCH63R_01668 CH63R_08584
ELAUCREL1_771 UCREL1_8646
PFYPFICI_02604 PFICI_13483 PFICI_14974
BFUBCIN_09g00680 BCIN_13g02220
PSCOLY89DRAFT_589972 LY89DRAFT_642918
GLZGLAREA_06058 GLAREA_09658 GLAREA_12088
ANIANIA_07821
AFMAFUA_5G14120
NFINFIA_072850
AORAO090023000875 AO090026000011 AO090038000063
ANGAn02g01090 An12g03210 An12g06400
AFVAFLA_006309 AFLA_007227 AFLA_012318
ALUCAKAW2_80215A
ACHEACHE_50053S
APUUAPUU_12296S APUU_20041S APUU_61047A
PCSN7525_000969
PDPPDIP_02390
POUPOX_f08371
UREUREG_06504
PNOSNOG_15959
PTEPTT_11290
BSCCOCSADRAFT_103200
AALTCC77DRAFT_1088875 CC77DRAFT_546209
ARABEKO05_0010085
FFUCLAFUR5_14299
CBETCB0940_10641
NPAUCRNP2_9593
SCMSCHCO_02748978(SCHCODRAFT_02748978)
 » show all
Reference
1  [PMID:8368836]
  Authors
Yabe K, Matsuyama Y, Ando Y, Nakajima H, Hamasaki T
  Title
Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin.
  Journal
Appl Environ Microbiol 59:2486-92 (1993)
DOI:10.1128/AEM.59.8.2486-2492.1993
Reference
2  [PMID:10584035]
  Authors
Zhou R, Linz JE
  Title
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus.
  Journal
Appl Environ Microbiol 65:5639-41 (1999)
DOI:10.1128/AEM.65.12.5639-5641.1999
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.349
IUBMB Enzyme Nomenclature: 1.1.1.349
ExPASy - ENZYME nomenclature database: 1.1.1.349
BRENDA, the Enzyme Database: 1.1.1.349
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