| Entry |
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| Name |
A-factor type gamma-butyrolactone 1'-reductase (1S-forming);
barS1 (gene name)
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
(3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one:NADP+ 1'-oxidoreductase
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| Reaction(IUBMB) |
a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP+ = a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H+ [RN: R11776]
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| Reaction(KEGG) |
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| Substrate |
(3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one [CPD: C21666];
NADP+ [CPD: C00006]
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| Product |
(3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one [CPD: C21668];
NADPH [CPD: C00005];
H+ [CPD: C00080]
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| Comment |
The enzyme, which is found in bacteria that produce virginiae-butanolide (VB) type gamma-butyrolactone autoregulators, reduces its substrate stereospecifically, forming a hydroxyl group in the (S) configuration.
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| History |
EC 1.1.1.413 created 2017
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| Orthology |
| K22322 | A-factor type gamma-butyrolactone 1'-reductase (1S-forming) |
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| Genes |
» show all
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| Reference |
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| Authors |
Shikura N, Yamamura J, Nihira T |
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| Title |
barS1, a gene for biosynthesis of a gamma-butyrolactone autoregulator, a microbial signaling molecule eliciting antibiotic production in Streptomyces species. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.1.1.413 |
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| LinkDB |
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