KEGG   ENZYME: 1.12.1.3
Entry
EC 1.12.1.3                 Enzyme                                 
Name
hydrogen dehydrogenase (NADP+);
NADP+-linked hydrogenase;
NADP+-reducing hydrogenase;
hydrogenase (ambiguous);
hydrogenase I (ambiguous)
Class
Oxidoreductases;
Acting on hydrogen as donor;
With NAD+ or NADP+ as acceptor
Sysname
hydrogen:NADP+ oxidoreductase
Reaction(IUBMB)
H2 + NADP+ = H+ + NADPH [RN:R07181]
Reaction(KEGG)
R07181
Substrate
H2 [CPD:C00282];
NADP+ [CPD:C00006]
Product
H+ [CPD:C00080];
NADPH [CPD:C00005]
Comment
The protein from the bacterium Desulfovibrio fructosovorans is an iron-sulfur protein that exclusively functions as a hydrogen dehydrogenase [1], while the enzyme from the archaeon Pyrococcus furiosus is a nickel, iron, iron-sulfur protein, that is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4, sulfhydrogenase). Different from EC 1.12.1.5, hydrogen dehydrogenase [NAD(P)+].
History
EC 1.12.1.3 created 2002, modified 2013
Orthology
K17992  NADP-reducing hydrogenase subunit HndB
K17993  sulfhydrogenase subunit alpha
K17994  sulfhydrogenase subunit delta
K18330  NADP-reducing hydrogenase subunit HndA
K18331  NADP-reducing hydrogenase subunit HndC
K18332  NADP-reducing hydrogenase subunit HndD
Genes
AVL: AvCA_04400(hoxH)
AVD: AvCA6_04400(hoxH)
ACX: Achr_4360(hoxY) Achr_4370(hoxH)
MSQ: BKP64_00955 BKP64_00960
MARA: D0851_07215 D0851_07220
PAEW: KIH87_09725 KIH87_09730
MICC: AUP74_02543(hoxH) AUP74_02544(hoxY)
MII: BTJ40_11460 BTJ40_11465
MICT: FIU95_09940(hoxH) FIU95_09945(hoxY)
MHYD: GTQ55_08910 GTQ55_08915
ALG: AQULUS_13030(hoxH) AQULUS_13040(hoxY)
ASIP: AQUSIP_08270(hoxY) AQUSIP_08280(hoxH)
LPN: lpg2467(hydA) lpg2468
LPH: LPV_2792 LPV_2793
LPO: LPO_2656 LPO_2657
LPU: LPE509_00593 LPE509_00594
LPM: LP6_2497(hydA) LP6_2498
LPF: lpl2387 lpl2388
LPP: lpp2532 lpp2533
LPC: LPC_2010 LPC_2011(hydA)
LPA: lpa_03596 lpa_03597
LPE: lp12_2459 lp12_2460
LLO: LLO_2450 LLO_2451
LOK: Loa_02480 Loa_02481
LSH: CAB17_17515 CAB17_17520
LIB: E4T55_10920 E4T55_10925
LGT: E4T54_10400 E4T54_10405
LJR: NCTC11533_01742(hoxH) NCTC11533_01743(hoxY)
LCJ: NCTC11976_02959(hoxY) NCTC11976_02962(hoxH_2)
LSS: NCTC12082_00642(hoxY) NCTC12082_00643(hoxH)
TMC: LMI_1438 LMI_1439
MMAI: sS8_1969 sS8_1970
FPH: Fphi_0818 Fphi_0819
FPT: BZ13_1195 BZ13_1196
FPI: BF30_1033 BF30_1034
FPM: LA56_1342 LA56_1343
FPX: KU46_521 KU46_522
FPZ: LA55_2065 LA55_2066
FPJ: LA02_420 LA02_421
FRT: F7308_1952 F7308_1953
FNA: OOM_1816
FNL: M973_00225
FRF: LO80_06090 LO80_06095
FHA: CDV26_00130 CDV26_00135
FRX: F7310_10160 F7310_10165
FRC: KX01_345 KX01_346
FMI: F0R74_08320 F0R74_08325
FSR: KQR59_09315 KQR59_09320
TLO: J9253_17480 J9253_17485
NHL: Nhal_1537 Nhal_1538
NWR: E3U44_15705 E3U44_15710
ALV: Alvin_0807 Alvin_0808
TEE: Tel_04925 Tel_04930
THIM: KFB96_22620 KFB96_22625
HHC: M911_03920 M911_03925
EBS: ECTOBSL9_1957 ECTOBSL9_1958
TGR: Tgr7_1137 Tgr7_1138
TNI: TVNIR_2169 TVNIR_2170(vhuG_[H])
TTI: THITH_06475 THITH_06480
TVR: TVD_13255 TVD_13260
APRS: BI364_04840 BI364_04845
HAZ: A9404_02270 A9404_02275
TTC: FOKN1_2277 FOKN1_2278
HSI: BOX17_10620 BOX17_10625
HBE: BEI_0366 BEI_0367
MGEO: CFI10_06200 CFI10_06205
MSEC: LN244_04715 LN244_04720
NCU: F0U83_02275 F0U83_02280
RFO: REIFOR_00615 REIFOR_00616
OCE: GU3_11735 GU3_11740
ZDF: AN401_10020 AN401_10025
GBI: PG2T_03070 PG2T_03075
SLIM: SCL_2124 SCL_2125
SVA: SVA_2158 SVA_2159
REV: HUE57_13155 HUE57_13160
ENM: EBS_0040 EBS_0041
NBA: CUN60_10630 CUN60_10635
BUZ: AYM40_36800 AYM40_36805
PARB: CJU94_13625 CJU94_13630
PVE: UC34_24700
PTX: ABW99_09705 ABW99_09710
BHO: D560_2878
BHM: D558_2856
NOK: FAY22_03480 FAY22_03485
BBAG: E1O_11220 E1O_11230
TBD: Tbd_1263
GEB: GM18_1856 GM18_1857 GM18_1858 GM18_1859
GPI: GPICK_09395
GEO: Geob_0218(bamH-1) Geob_0234(bamH-2)
GBN: GEOBRER4_17890 GEOBRER4_17900
GSB: GSUB_14255 GSUB_14260
GER: KP004_08740 KP004_08745
GSUB: KP001_06415 KP001_06420
GNT: KP003_08265 KP003_08270
PCA: Pcar_1602(hndA-3) Pcar_1603(hndB-3) Pcar_1604(hndC-3) Pcar_1605(hndD-3) Pcar_1633(hndD-2) Pcar_1634(hndC-2) Pcar_1635(hndB-2) Pcar_1636(hndA-2) Pcar_1844(hndC-1) Pcar_1845(hndB-1) Pcar_1846(hndA-1) Pcar_2708(hndC-5)
PACE: A6070_04705 A6070_07085 A6070_07090 A6070_07095 A6070_07100 A6070_07285 A6070_07950 A6070_07955 A6070_07960 A6070_07965 A6070_09010
PEF: A7E78_02215 A7E78_02220 A7E78_02225 A7E78_02230 A7E78_06775 A7E78_06780
PPD: Ppro_3516 Ppro_3517 Ppro_3518
DES: DSOUD_2750 DSOUD_2751 DSOUD_3307 DSOUD_3308
DEU: DBW_2713 DBW_2714 DBW_3345 DBW_3346
DVE: DESUT3_12230 DESUT3_12240
DFL: DFE_3279 DFE_3280
DSD: GD606_13030 GD606_13035
DMA: DMR_02450 DMR_02460 DMR_02470(nuoF) DMR_02480
DCB: C3Y92_00825 C3Y92_00830 C3Y92_00835 C3Y92_00840
DAF: Desaf_2138 Desaf_2139
DSX: GD604_00285 GD604_00290
DSF: UWK_01340 UWK_01341
DML: Dmul_28600(nuoF3) Dmul_34230(morB)
DAL: Dalk_2271
DAT: HRM2_16520
DTO: TOL2_C03720(bamH1) TOL2_C28870 TOL2_C28900 TOL2_C41380(bamH2) TOL2_C43510(bamH3)
DOV: DSCO28_20310 DSCO28_66020
DALK: DSCA_31590 DSCA_31610 DSCA_35390 DSCA_35400
DLI: dnl_05790 dnl_18600 dnl_18610(nuoF) dnl_49300
DMM: dnm_034430 dnm_042000(nuoF1) dnm_042010 dnm_042020
DEK: DSLASN_10770 DSLASN_26630 DSLASN_26640 DSLASN_26650 DSLASN_26660
CFUS: CYFUS_000606 CYFUS_000607
SCL: sce4575(hoxH)
SCU: SCE1572_36515 SCE1572_36520
LLU: AKJ09_02923 AKJ09_02924
SAT: SYN_00152 SYN_02221 SYN_02222
DAO: Desac_1693 Desac_1694
DTI: Desti_1918 Desti_2752 Desti_2753
DAX: FDQ92_01160(nuoF)
DBR: Deba_0481 Deba_0785 Deba_1519 Deba_1520 Deba_2120
PCAY: FRD00_01940 FRD00_01945
OCA: OCAR_5286
OCG: OCA5_c26870
OCO: OCA4_c26860
BID: Bind_0506 Bind_0507
MSC: BN69_0845 BN69_0846
MROS: EHO51_04985 EHO51_04990
MPAR: F7D14_01855 F7D14_01860
MTW: CQW49_20325 CQW49_20330
LABP: FJ695_24195
RRF: F11_01565
MGY: MGMSRv2__1308 MGMSRv2__1309
MGRY: MSR1_09580(hoxH) MSR1_09590(hoxY)
DEX: HWD60_06920 HWD60_06925
MAGQ: MGMAQ_3148 MGMAQ_3149
MGM: Mmc1_0883
AFR: AFE_0937(hoxH) AFE_0938(hoxY)
AFE: Lferr_1055 Lferr_1056
AFI: Acife_1820 Acife_1821
AFJ: AFERRID_21540 AFERRID_21550
PAEQ: R50912_06580 R50912_06585
PAEA: R70723_15795 R70723_15800
PAEE: R70331_15235 R70331_15240
PBAC: HUB98_24435
PTJ: JRJ22_12795(nuoF) JRJ22_12800
LRN: CMV25_02440 CMV25_02445
EGV: EGCR1_07010 EGCR1_07015
EAV: EH197_17435(nuoF) EH197_17440
ERAF: J9537_09250(nuoF) J9537_09255
CBK: CLL_A2000
CBT: CLH_1604 CLH_1644
CBE: Cbei_1773
CBZ: Cbs_1773
CBEI: LF65_01916 LF65_03652
CLJ: CLJU_c07040
CCB: Clocel_2588
CLS: CXIVA_00910 CXIVA_06850 CXIVA_14930 CXIVA_16350 CXIVA_21460(NuoF) CXIVA_23660 CXIVA_23670(NuoF) CXIVA_23680 CXIVA_23700(NuoE)
CLB: Clo1100_0751 Clo1100_2676 Clo1100_2677 Clo1100_2678 Clo1100_2680
CSR: Cspa_c24540 Cspa_c33070(hndD1) Cspa_c35380 Cspa_c47550(nuoF)
CPAT: CLPA_c34400(hndC)
CPAE: CPAST_c34400(hndC)
CSB: CLSA_c23760(hndD)
CAH: CAETHG_2795
CSQ: CSCA_4946
CACE: CACET_c32700 CACET_c32710 CACET_c32730 CACET_c32740 CACET_c35720(nuoG) CACET_c35740
CCK: Ccar_16070
CTAE: BGI42_08165
CFM: BJL90_01765 BJL90_01780 BJL90_01785
CDRK: B9W14_20080
CIA: BEN51_01050 BEN51_03310
CDY: F3K33_08790
CFER: D4Z93_04800
CLOS: DMR38_03370
CCAA: KQH81_00505
AMT: Amet_0638 Amet_0639 Amet_0640 Amet_4100 Amet_4101 Amet_4109
GFE: Gferi_09405 Gferi_20695 Gferi_20705 Gferi_20765 Gferi_20770 Gferi_22870 Gferi_22875
CALE: FDN13_01610 FDN13_01615(nuoF) FDN13_01620 FDN13_10460 FDN13_12880 FDN13_12885
CRS: FQB35_03905 FQB35_03910(nuoF) FQB35_03915 FQB35_11220 FQB35_14710
CPRF: K7H06_03105 K7H06_03110(nuoF) K7H06_03115 K7H06_03125 K7H06_03130(nuoF) K7H06_03135 K7H06_11915 K7H06_17800
PBIF: KXZ80_11255
CAZO: G3A45_06540 G3A45_06545 G3A45_11645 G3A45_11650(nuoF) G3A45_11655 G3A45_11715 G3A45_11730
CTH: Cthe_0338 Cthe_0340 Cthe_0341 Cthe_0342
CTX: Clo1313_1881 Clo1313_1882 Clo1313_1883 Clo1313_1885
CCL: Clocl_1309 Clocl_1311 Clocl_1312 Clocl_1313
HSC: HVS_11610(hndB1) HVS_12575(hndD2) HVS_12580(hndC2) HVS_12585(hndB2) HVS_12595(hndA2)
RUK: A4V00_14230 A4V00_14235 A4V00_14240
CCE: Ccel_2232 Ccel_2233 Ccel_2234 Ccel_2236 Ccel_2467
RHER: EHE19_005425(nuoE) EHE19_005435 EHE19_005440(nuoF) EHE19_005445
CSS: Cst_c09400(nuoE) Cst_c09420 Cst_c09430(nuoF2) Cst_c09440
CSD: Clst_0900(fhbA) Clst_0902(fdx1) Clst_0903(fhbB) Clst_0904(fhbC)
CTHD: CDO33_16050 CDO33_16055 CDO33_16060 CDO33_16070
ESR: ES1_19890 ES1_19910 ES1_19930
ESU: EUS_11280 EUS_11300 EUS_11320
CCEL: CCDG5_0742 CCDG5_0743(hndC) CCDG5_0744(hndD)
FPLA: A4U99_00370 A4U99_03555 A4U99_03560 A4U99_03565
EHA: Ethha_2293
RAL: Rumal_2964 Rumal_2965
RCH: RUM_16060 RUM_16080 RUM_16090 RUM_16100
CAPR: EQM14_01110
OVA: OBV_29610
SMAN: C12CBH8_13120 C12CBH8_13130 C12CBH8_13140 C12CBH8_13160
CFEM: HCR03_13575
ACOL: K5I23_04445
CLE: Clole_2394 Clole_2395 Clole_2396 Clole_2397
CEW: EKH84_14585 EKH84_14590 EKH84_14595
CCT: CC1_10620 CC1_10630 CC1_10640
CCOM: I6K69_07370
BPRO: PMF13cell1_04623(hndD_2)
CPY: Cphy_2056 Cphy_3801 Cphy_3803 Cphy_3804 Cphy_3805
LACY: A4V08_01515 A4V08_10155 A4V08_10160 A4V08_10165
CSCI: HDCHBGLK_00083(hndD_1) HDCHBGLK_00084(hndC_1) HDCHBGLK_00085(hndB) HDCHBGLK_00087(hndA) HDCHBGLK_00500(hndD_2)
CSH: Closa_3390 Closa_3392 Closa_3393 Closa_3394
CSO: CLS_02870
BPRL: CL2_24320
ARF: AR1Y2_2834
ACAC: EYQ97_04130
HSD: SD1D_2323 SD1D_2324(hndC) SD1D_2325(hndD)
LUA: D4A81_12960
EHL: EHLA_0358 EHLA_2242
ANR: Ana3638_06225 Ana3638_06230(nuoF) Ana3638_06235
ACEL: acsn021_01000 acsn021_01010 acsn021_01020 acsn021_01040
ACHT: bsdcttw_47950 bsdcttw_47960 bsdcttw_47970
EEL: EUBELI_00201
RTO: RTO_15320
CBOL: CGC65_22485 CGC65_22490 CGC65_22495 CGC65_22580
DLO: K5I24_14130
LBW: C3V36_13275 C3V36_13280 C3V36_13285
EAC: EAL2_808p02660 EAL2_c04310(hymC)
PSOR: RSJ16_04570 RSJ16_12970
ROC: HF520_03830
PHX: KGNDJEFE_00571(hndD)
TEM: JW646_04820
TEB: T8CH_1954(hndD) T8CH_2293(hndD) T8CH_3077(hndD)
SWO: Swol_0784 Swol_1701 Swol_2436
SLP: Slip_0124 Slip_0543 Slip_2098
SALQ: SYNTR_0507 SYNTR_1606 SYNTR_1607
SGY: Sgly_2185 Sgly_2914
DED: DHBDCA_p1588(hymB) DHBDCA_p1589 DHBDCA_p1590(hymA) DHBDCA_p1640 DHBDCA_p874(hymC)
DEC: DCF50_p1598(hymB) DCF50_p1599 DCF50_p1600(hymA) DCF50_p1649 DCF50_p933(hymC)
DRS: DEHRE_08805 DEHRE_11740 DEHRE_11745 DEHRE_11750 DEHRE_11890 DEHRE_12025
DCA: Desca_1017 Desca_1224 Desca_1225 Desca_1997 Desca_1998
PTH: PTH_1377 PTH_1378(NuoF) PTH_2010
DRM: Dred_0463 Dred_1651
DRU: Desru_0515 Desru_0516 Desru_2397 Desru_2398 Desru_3431
DFG: B0537_03245 B0537_07840 B0537_07845
DAE: Dtox_0172 Dtox_0173 Dtox_0174 Dtox_0176 Dtox_3504 Dtox_3829 Dtox_3830
DKU: Desku_0995 Desku_1528 Desku_2307 Desku_2308 Desku_2309 Desku_2311
DAU: Daud_0109 Daud_0152 Daud_1338 Daud_1548 Daud_1923
TFR: BR63_13425 BR63_13430(nuoF) BR63_13435 BR63_13440(nuoE) BR63_18510 BR63_18515 BR63_18520
FWA: DCMF_01595 DCMF_07650 DCMF_07660 DCMF_07665 DCMF_20805
TJR: TherJR_0743 TherJR_2550 TherJR_2551 TherJR_2552
DGI: Desgi_1115 Desgi_1983 Desgi_2137
HMO: HM1_1029(nuoG)
HCV: FTV88_2333 FTV88_2334 FTV88_2507 FTV88_2509
ELM: ELI_0845 ELI_0846 ELI_0847
EMT: CPZ25_017165 CPZ25_017170 CPZ25_017175
ELIM: B2M23_11915 B2M23_11925 B2M23_11930 B2M23_11935
AWO: Awo_c26970(hydA1) Awo_c26980(hydB) Awo_c26990(hydD)
ALKA: J0B03_01890 J0B03_02965 J0B03_03015
CTHM: CFE_2039 CFE_2040 CFE_2217
CMIU: B1H56_03765 B1H56_04375 B1H56_04380 B1H56_04385
IBU: IB211_00393 IB211_00394 IB211_00395
CBAR: PATL70BA_1019(hndD) PATL70BA_1020(hndC) PATL70BA_1021 PATL70BA_2848(hndD)
VGU: HYG85_00670 HYG85_10350 HYG85_10355 HYG85_10360 HYG85_15080 HYG85_15085 HYG85_15090
VPY: HZI73_02030 HZI73_02035 HZI73_02040 HZI73_06730 HZI73_11280 HZI73_20445 HZI73_22865 HZI73_22870 HZI73_22875 HZI73_22880
ACAE: HYG86_02045(nuoF) HYG86_02050 HYG86_03675 HYG86_07620
LASA: L9O85_09690 L9O85_09700
MDV: C5Q96_03535 C5Q96_03540
ETM: CE91St48_32250
BPRM: CL3_28570
BPRS: CK3_02010
TTE: TTE0892 TTE0893(NuoF) TTE0894(NuoG)
TEX: Teth514_2138 Teth514_2139 Teth514_2140
THX: Thet_0795 Thet_0796 Thet_0797
TPD: Teth39_1456 Teth39_1457 Teth39_1458
TIT: Thit_0828 Thit_0829 Thit_0830
TMT: Tmath_0867 Tmath_0868 Tmath_0869
TBO: Thebr_1491 Thebr_1492 Thebr_1493
TWI: Thewi_0978 Thewi_0979 Thewi_0980
TKI: TKV_c19580(hydA1)
MTA: Moth_1717 Moth_1718
MTHO: MOTHE_c17260(hndD1) MOTHE_c17270(hndC1)
MTHZ: MOTHA_c18090(hndD1) MOTHA_c18100(hndC1)
ADG: Adeg_0290 Adeg_0332
TPZ: Tph_c18450 Tph_c26910 Tph_c26920
GEK: kuro4_25690
CSC: Csac_1860 Csac_1862 Csac_1863 Csac_1864
ATE: Athe_1295 Athe_1297 Athe_1298 Athe_1299
COB: COB47_1258 COB47_1259 COB47_1260 COB47_1262
CHD: Calhy_1427 Calhy_1428 Calhy_1429 Calhy_1431
COW: Calow_1086 Calow_1088 Calow_1089 Calow_1090
CKI: Calkr_1280 Calkr_1282 Calkr_1283 Calkr_1284
CLC: Calla_0683 Calla_0685 Calla_0686 Calla_0687
CKN: Calkro_1402 Calkro_1403 Calkro_1404 Calkro_1406
CCHA: ELD05_06980 ELD05_06985(nuoF) ELD05_06990 ELD05_07000(nuoE)
CDIA: CaldiYA01_12070
TTM: Tthe_1116 Tthe_1118 Tthe_1119 Tthe_1120
TTO: Thethe_01060 Thethe_01062 Thethe_01063 Thethe_01064
TXY: Thexy_1580 Thexy_1581 Thexy_1582 Thexy_1584
TSH: Tsac_2126 Tsac_2127 Tsac_2128 Tsac_2130
TACI: TDSAC_1040
MAS: Mahau_1250 Mahau_1252 Mahau_1253 Mahau_1254 Mahau_1381 Mahau_1382
TEP: TepRe1_1888 TepRe1_1889 TepRe1_1890
TAE: TepiRe1_2033(hndD) TepiRe1_2034(hndC) TepiRe1_2035
TOC: Toce_0693 Toce_0695 Toce_0696 Toce_0697
NTH: Nther_0098 Nther_0099 Nther_0703
NCD: ACONDI_00300(hndD) ACONDI_02921(hndB_2)
HOR: Hore_06320
HAS: Halsa_1862 Halsa_1863 Halsa_1864 Halsa_1866
HPK: Hprae_1627 Hprae_1628 Hprae_1629 Hprae_1631
HALS: D7D81_01595 D7D81_01605 D7D81_17425
IFN: GM661_14115 GM661_14135 GM661_17630 GM661_17640
AAR: Acear_0268 Acear_0269 Acear_0270 Acear_0271 Acear_0532 Acear_0982 Acear_1883 Acear_1884 Acear_2301 Acear_2302
HHL: Halha_0376 Halha_0377 Halha_2285 Halha_2286 Halha_2287 Halha_2289
AFT: BBF96_04540 BBF96_04550 BBF96_07410 BBF96_07415 BBF96_09125 BBF96_09130 BBF96_09135
KME: H0A61_01405(hndC_2) H0A61_01871(hndA_4) H0A61_01873(hndB_1) H0A61_01874(hndC_4) H0A61_01875(hndD_3) H0A61_01878(hndA_5) H0A61_01879(hndB_2) H0A61_01881(hndD_4)
FMA: FMG_1155
PMIC: NW74_03325 NW74_07160
PHAR: NCTC13077_00350(nqo1)
SPOA: EQM13_17995 EQM13_18000 EQM13_18005
KPAR: JL105_09265 JL105_10660
SEDZ: JYG23_10935(nuoE) JYG23_10940 JYG23_10945(nuoF) JYG23_10950
MED: MELS_0888
MEG: DKB62_05660 DKB62_05665 DKB62_11300
MMAX: LCQ47_05555
SSG: Selsp_1525
SRI: SELR_26360
MHG: MHY_20970
MFUN: GXM21_01745 GXM21_01755
PUF: UFO1_1386
PFT: JBW_04037 JBW_04038 JBW_04039
MANA: MAMMFC1_00410 MAMMFC1_00827(hndD_2) MAMMFC1_00828(hndC_3) MAMMFC1_00830(hndD_3) MAMMFC1_00831(hndC_4) MAMMFC1_00940(hndD_4)
STED: SPTER_13820(hndD_1) SPTER_13950(sfrA) SPTER_14070(hndB) SPTER_14080(hndC_2) SPTER_14090(hndD_3)
AFN: Acfer_1955
AIN: Acin_2259(nuoG)
PFAC: PFJ30894_00902(hndB) PFJ30894_00903(hndC) PFJ30894_00904(hndD_1)
CIU: G4D55_17605
ERM: EYR00_09750 EYR00_09785 EYR00_09790 EYR00_09795
BULL: JOS54_06760
EBM: SG0102_13030
LCG: L3BBH23_06690
ERB: A4V01_20385
TUR: AT726_09495 AT726_09500 AT726_09505
TSG: HLK68_09355 HLK68_09360(nuoF) HLK68_09365
LPIL: LIP_0582 LIP_0583 LIP_0871
MANR: MPAN_008040 MPAN_013430 MPAN_013450
MBJ: KQ51_00322(hndB_1) KQ51_00323(hndC_1) KQ51_00324 KQ51_00791(hndD_1) KQ51_01818(hndB_2) KQ51_01835(nuoG)
TBM: BK010_06995 BK010_07000 BK010_07005
TBZ: BK011_07465 BK011_07470 BK011_07475
MMAN: MMAN_14450 MMAN_14460
MMC: Mmcs_3416 Mmcs_3417
MKM: Mkms_3479 Mkms_3480
MJL: Mjls_3427 Mjls_3428
MMI: MMAR_3497 MMAR_3498
MMAE: MMARE11_34090 MMARE11_34100
MLI: MULP_03750
MKN: MKAN_04225 MKAN_04230
MYE: AB431_12170 AB431_12175
MHAD: B586_16665 B586_16670
MSHG: MSG_02854 MSG_02855
MSTO: MSTO_04520 MSTO_04530
MSAK: MSAS_49680 MSAS_49690
MNV: MNVI_35470 MNVI_35480
MPAG: C0J29_14650 C0J29_14655
MGOR: H0P51_17800 H0P51_17805
MBAI: MB901379_03108(hoxH) MB901379_03109(hoxY)
MSEO: MSEO_00840 MSEO_00850
MPSE: MPSD_35740 MPSD_35750
MHEK: JMUB5695_01550(hoxH) JMUB5695_01551
MLJ: MLAC_23590 MLAC_23600
MBRD: MBRA_29200
MSHJ: MSHI_09600 MSHI_09610
MDF: K0O62_06400
MHER: K3U94_12980 K3U94_12985
MPAE: K0O64_11895
MSPG: F6B93_12825 F6B93_12830
MOT: LTS72_06950 LTS72_06955
MSM: MSMEG_3928
MSG: MSMEI_3838
MSB: LJ00_19525 LJ00_19530
MSN: LI99_19530 LI99_19535
MSH: LI98_19535 LI98_19540
MCB: Mycch_1699
MLL: B1R94_11315 B1R94_11320
MTHN: 4412656_03554(hoxY) 4412656_03555(hoxH)
MDU: MDUV_51500 MDUV_51510
MAIC: MAIC_21360 MAIC_21370
MPSC: MPSYJ_48130 MPSYJ_48140
MANY: MANY_17730 MANY_17740
CPEG: CPELA_10915
NSR: NS506_04373(hydA) NS506_04374(mvhG)
NAH: F5544_17320 F5544_17325
NTC: KHQ06_22645 KHQ06_22650
NGP: LTT66_32155
RER: RER_34040
REQ: REQ_15170
RAV: AAT18_20765 AAT18_20770
RHW: BFN03_07920 BFN03_07925
SCB: SCAB_10361
SHY: SHJG_8771 SHJG_8772
SHO: SHJGH_8527 SHJGH_8528
SRC: M271_48220 M271_48225
SMAL: SMALA_7420 SMALA_7421
SSOI: I1A49_40860 I1A49_40865
SDV: BN159_8137 BN159_8138
SXI: SXIM_54300 SXIM_54310
STRM: M444_33590 M444_33595
SCX: AS200_40165 AS200_40170
SRW: TUE45_pSRc_0046(hoxH) TUE45_pSRc_0047(hoxY)
SPLU: LK06_000325 LK06_000330
SAUO: BV401_40720 BV401_40725
SGV: B1H19_03575 B1H19_03580
SLAU: SLA_6981
SALF: SMD44_08103 SMD44_08104
SALJ: SMD11_1043 SMD11_1044
STRO: STRMOE7_01900 STRMOE7_01905
SFK: KY5_7224 KY5_7225
SGE: DWG14_00278(hoxY) DWG14_00279(hoxH)
SCYA: EJ357_43835 EJ357_43840
SNQ: CP978_06415 CP978_06420
STIR: DDW44_00725 DDW44_00730
SKA: CP970_03590 CP970_03595
SGZ: C0216_13070 C0216_13075
SVR: CP971_32660 CP971_32665
SAQU: EJC51_04405 EJC51_04410
SRIM: CP984_01485 CP984_01490
SPHV: F9278_19940
SFUG: CNQ36_00175 CNQ36_00180
SCHF: IPT68_01195 IPT68_01200
SFEU: IM697_26300 IM697_26305
SMOB: J7W19_00255 J7W19_00260
SROI: IAG44_01410 IAG44_01415
ACTW: F7P10_09095 F7P10_09100
SRO: Sros_4826
NOA: BKM31_18850 BKM31_18855
NOW: GBF35_15985 GBF35_15990
NCX: Nocox_21175(hoxH)
TBI: Tbis_1858
FRA: Francci3_4496 Francci3_4497
ACE: Acel_1018 Acel_1019
PDX: Psed_3296
PHH: AFB00_26060
KAL: KALB_4152 KALB_4157
PSUU: Psuf_068760 Psuf_068770
ATL: Athai_08880 Athai_08890
DVC: Dvina_37845
SNA: Snas_3473 Snas_3474
RUB: GBA63_20400 GBA63_20405
SHI: Shel_16530
ELE: Elen_1255 Elen_1256
EYY: EGYY_04050 EGYY_12130 EGYY_12140 EGYY_15690
EGD: GS424_006590 GS424_006595
GPA: GPA_23180
AEQ: AEQU_0878 AEQU_0879 AEQU_2224
AHAT: ADCFC_00730 ADCFC_14510 ADCFC_14520
OLS: Olsu_0826 Olsu_1006
TIO: INP52_07055
CGO: Corgl_0838
CAER: CSV91_04530
ERZ: ER308_18500
LBO: LBWT_7400 LBWT_7410
CYN: Cyan7425_2660 Cyan7425_2661
DLY: Dehly_0928 Dehly_0929
DEW: DGWBC_1203 DGWBC_1204
DFO: Dform_00601 Dform_00602
ATM: ANT_17790 ANT_17800 ANT_17820
ABAT: CFX1CAM_1213 CFX1CAM_1215 CFX1CAM_1216
PSUB: Pelsub_P1914 Pelsub_P1915 Pelsub_P1917
ABAO: BEQ56_02675
CAP: CLDAP_19260
THUG: KNN16_04355 KNN16_04360
TTR: Tter_1539
OTE: Oter_1545
MIN: Minf_2390(frhG) Minf_2391(frhA)
MKC: kam1_1223 kam1_2094 kam1_2096
VBS: EGM51_01930(nuoF) EGM51_01935
LCRE: Pla8534_67850(hoxY) Pla8534_67860(hoxH)
AAGG: ETAA8_22830(hoxY) ETAA8_22850
TTF: THTE_2881 THTE_3843
FMR: Fuma_01323(hoxH) Fuma_01324(hoxY)
GMR: GmarT_18740(hoxY) GmarT_18750(hoxH)
GIM: F1728_26570 F1728_26575
GPN: Pan110_37740(hoxH) Pan110_37750(hoxY)
MRI: Mal4_24330(hoxH) Mal4_24340(hoxY)
KST: KSMBR1_0596(nuoF_1) KSMBR1_1330(nuoF_2) KSMBR1_3673(hoxY) KSMBR1_3674(hoxH)
BROC: IPI25_00220(nuoE) IPI25_07695(nuoF)
PBU: L21SP3_00034(hndD_1) L21SP3_00309(hndD_2) L21SP3_00310(hndC_3)
PBP: STSP1_00009(hndD_1) STSP1_00010(hndC_1) STSP1_01250(hndD_2)
PBAS: SMSP2_01580(hndB) SMSP2_01581(hndC_2) SMSP2_01582(hndD_2) SMSP2_01657(hndD_3)
ALUS: STSP2_01432(hndB) STSP2_01433(hndC) STSP2_01434(hndD) STSP2_01452(hoxH) STSP2_01453(hoxY)
VBL: L21SP4_00378 L21SP4_00379 L21SP4_00380 L21SP4_01302(hndD_2)
TAER: GT409_10650 GT409_10655 GT409_10660 GT409_14280 GT409_14290
VAI: BU251_02010 BU251_02015 BU251_02020 BU251_07790 BU251_07795
TBE: Trebr_0332 Trebr_0333
TAZ: TREAZ_3248 TREAZ_3249
TPI: TREPR_3595
TPED: TPE_0917 TPE_2309
SCD: Spica_2775
TPK: JO40_11355
TRZ: GWP43_12150
TRC: DYE49_00610 DYE49_00615 DYE49_00620
SSM: Spirs_0474 Spirs_3688 Spirs_3689
STA: STHERM_c06260 STHERM_c13740 STHERM_c13750 STHERM_c13760
STQ: Spith_1507 Spith_1508 Spith_1509
SFC: Spiaf_1750 Spiaf_2407 Spiaf_2409
SPER: EW093_05445 EW093_05450
SLR: L21SP2_0274 L21SP2_0275
OCK: EXM22_15350 EXM22_15355(nuoF) EXM22_15360
SBU: SpiBuddy_2313 SpiBuddy_2314
SCC: Spico_0354
SGP: SpiGrapes_2477 SpiGrapes_2478
BHC: JFL75_09000 JFL75_09005
TPX: Turpa_2746
BHY: BHWA1_02502(hymC) BHWA1_02503(nuoF)
BHD: BHYOB78_03730 BHYOB78_03735
BRM: Bmur_2160
BIP: Bint_0726(hymC) Bint_0727(nuoF)
BHP: BHAMNSH16_10855 BHAMNSH16_10860
EMI: Emin_0532 Emin_0533
EPO: Epro_0734(hydA) Epro_0735(hydB) Epro_0736
FVA: FV113G1_03860(nuoF) FV113G1_03870(nuoG) FV113G1_24290 FV113G1_26580
FUL: C4N20_00705 C4N20_04455 C4N20_04460 C4N20_10420
FMO: C4N19_00165 C4N19_03610 C4N19_03615
FGO: C4N16_04400
FNF: BSQ88_02970 BSQ88_02975
IPO: Ilyop_0625 Ilyop_0626 Ilyop_0627 Ilyop_0628 Ilyop_0635 Ilyop_0689 Ilyop_0690 Ilyop_2431
LEO: AMK43_00690 AMK43_00695 AMK43_00700
STR: Sterm_0623 Sterm_0624 Sterm_0625 Sterm_3599 Sterm_3600 Sterm_3601
TAI: Taci_0147 Taci_0148 Taci_0149 Taci_0150
ACO: Amico_1557
TLI: Tlie_1466 Tlie_1619
AMO: Anamo_0024 Anamo_1679
CPOR: BED41_00310 BED41_00320 BED41_05425
BTH: BT_0123 BT_0124 BT_0125
BTHO: Btheta7330_03239(hndC) Btheta7330_03240(hndD) Btheta7330_03241(hndA)
BXY: BXY_41360 BXY_41370 BXY_41380
BOA: Bovatus_04980(hndA) Bovatus_04981(hndD) Bovatus_04982(hndC)
BCEL: BcellWH2_04988(hndC) BcellWH2_04989(hndD) BcellWH2_04990(hndA)
BCAC: CGC64_09630 CGC64_09635 CGC64_09640
BHF: C3V43_03950 C3V43_03955 C3V43_03960
BIS: DXK01_013735 DXK01_013740 DXK01_013745(nuoE)
BFE: K6V30_13375(nuoE) K6V30_13380 K6V30_13385
BNO: K8P02_07460 K8P02_07465 K8P02_07470
BVU: BVU_0396
PBT: ING2E5B_2397 ING2E5B_2398(hndC) ING2E5B_2399(hndD) ING2E5B_2400
PMUC: ING2E5A_0853(hndB) ING2E5A_0854(hndC) ING2E5A_0855(hndD) ING2E5A_0856(hndA)
PET: PEIBARAKI_6525 PEIBARAKI_6526 PEIBARAKI_6527 PEIBARAKI_6528
PSAC: PSM36_3019 PSM36_3020(hndD) PSM36_3021(hndC) PSM36_3022
PDI: BDI_1042 BDI_1043 BDI_1044 BDI_1045
PARC: CI960_08930 CI960_08935 CI960_08940 CI960_08945
PMER: INE87_00694(hndA) INE87_00695(hndD) INE87_00696(hndC) INE87_00697(hndB)
PGOL: K6V26_09170 K6V26_09175 K6V26_09180 K6V26_09185
PJO: LK449_07260 LK449_07265 LK449_07270 LK449_07275
OSP: Odosp_0184 Odosp_0185 Odosp_0186 Odosp_0187
BUY: D8S85_07440 D8S85_07445 D8S85_07450 D8S85_07455
BVIR: I6J59_09400 I6J59_09405 I6J59_09410 I6J59_09415
RBC: BN938_1638 BN938_2212 BN938_2258
TTZ: FHG85_08335 FHG85_08495 FHG85_09610(nuoE) FHG85_09615 FHG85_09620 FHG85_09625 FHG85_09660
BLQ: L21SP5_00769(hndB) L21SP5_00770(hndC_2) L21SP5_00771(hndD_1) L21SP5_00772(hndA_2) L21SP5_00830(hndD_2)
BACC: BRDCF_p1395(nuoE2) BRDCF_p1396(nuoG) BRDCF_p1397(nuoF2) BRDCF_p1398 BRDCF_p1719
DORI: FH5T_02925 FH5T_03065 FH5T_03070 FH5T_03075 FH5T_03080
DRC: G0Q07_16470 G0Q07_16595 G0Q07_16600 G0Q07_16605 G0Q07_16610
MCOS: GM418_18965 GM418_18970 GM418_18975 GM418_18980 GM418_20635
ASX: CDL62_11530 CDL62_11585 CDL62_11590 CDL62_11595 CDL62_11600
MBAS: ALGA_2626 ALGA_2627 ALGA_2628 ALGA_2629 ALGA_3125
RMR: Rmar_2590
RMG: Rhom172_2606
FLS: GLV81_05450
MGOT: MgSA37_01986(hoxY) MgSA37_01987(hoxH)
LUT: Lupro_00310
CPC: Cpar_0317 Cpar_0318
CLZ: BIU88_10290 BIU88_10295
CCH: Cag_0245
CPH: Cpha266_2168 Cpha266_2169
CPB: Cphamn1_2131 Cphamn1_2132
CLI: Clim_2096 Clim_2097
PPH: Ppha_2498 Ppha_2499
PAA: Paes_1928 Paes_1929
PROC: Ptc2401_02008(hoxY) Ptc2401_02009(hoxH)
PRS: B9H02_09675
PROS: CHL67_10255 CHL67_10260
CTS: Ctha_0344
CACI: CLOAM1181 CLOAM1183(hymB) CLOAM1184
HTE: Hydth_0495 Hydth_0496
SAF: SULAZ_0894 SULAZ_0896
PMX: PERMA_0690 PERMA_0692
TAM: Theam_0484
DTE: Dester_0745
TMA: TM0011
TMM: Tmari_0008 Tmari_0199
TMI: THEMA_03725 THEMA_04745
TMW: THMA_0007 THMA_0208
TMQ: THMB_0007 THMB_0208
TMX: THMC_0007 THMC_0208
TPT: Tpet_0912
TRQ: TRQ2_0934
TNA: CTN_0687
TNP: Tnap_0642
THQ: T2812B_03795 T2812B_04725
THZ: CELL2_04735
THR: TRQ7_04910
TLE: Tlet_1518 Tlet_1521
TTA: Theth_0092 Theth_1566 Theth_1569
PHY: AJ81_00105 AJ81_08385 AJ81_08400
TME: Tmel_1168 Tmel_1171
TAF: THA_1554 THA_1558 THA_1808
THP: BG95_06645 BG95_06660 BG95_08710
THER: Y592_06725 Y592_06740 Y592_08815
TFE: JYK00_00830
FNO: Fnod_0236 Fnod_0991 Fnod_0994
FPE: Ferpe_0291 Ferpe_0292 Ferpe_1116 Ferpe_1120
FIA: NA23_05520 NA23_05535
OCY: OSSY52_17030 OSSY52_21290(hymB) OSSY52_21300 OSSY52_21310
PMO: Pmob_0724 Pmob_0725 Pmob_0726 Pmob_1149
MPZ: Marpi_1895 Marpi_1896 Marpi_1897
MARN: LN42_10050 LN42_10055
DTN: DTL3_0214 DTL3_0799(hndD3)
KOL: Kole_0172 Kole_0181 Kole_0184
KPF: IX53_02690 IX53_02705 IX53_02780
MPG: Theba_0461 Theba_0464
MINF: MESINF_2168 MESINF_2171
ASAC: ATHSA_0551 ATHSA_0552 ATHSA_0845 ATHSA_1936
CPO: COPRO5265_0177 COPRO5265_0179 COPRO5265_0180 COPRO5265_0181
CEX: CSE_11940 CSE_11960 CSE_11970
CNI: Calni_1549
CABY: Cabys_3228 Cabys_3229 Cabys_3677 Cabys_3678
DTH: DICTH_0768
DTU: Dtur_0918
TYE: THEYE_A1853 THEYE_A1854
DTP: JZK55_04700(hydA) JZK55_04710 JZK55_05510 JZK55_11800 JZK55_21900 JZK55_21910 JZK55_21920
NIO: NITINOP_0586(hydA) NITINOP_0587(hydD)
THET: F1847_07590
NLI: G3M70_06690 G3M70_06695 G3M70_15045
ALAM: RT761_02739(hndD_2)
BANA: BARAN1_0488 BARAN1_0490(HoxF) BARAN1_0495
BIH: BIP78_1096 BIP78_1098 BIP78_1103
MOX: DAMO_0854
WWE: P147_WWE3C01G0331 P147_WWE3C01G0332
MIB: UY43_C0001G0070
PFU: PF0893 PF0894 PF1331 PF1332
PFI: PFC_03675 PFC_03680 PFC_05870 PFC_05875
PHO: PH1292(PH1292) PH1294(PH1294)
PAB: PAB0640(hydD-2) PAB0641(hydA-2) PAB1786 PAB1787
PYN: PNA2_1551 PNA2_1553 PNA2_1665 PNA2_1666
PYA: PYCH_00040 PYCH_00050 PYCH_08370 PYCH_08380
PYS: Py04_0892 Py04_0893 Py04_1129 Py04_1130
PYC: TQ32_02785 TQ32_02790 TQ32_03115 TQ32_03120
TKO: TK2069 TK2070
TON: TON_0052 TON_0053 TON_0534 TON_0535
TSI: TSIB_0284 TSIB_0285 TSIB_1522 TSIB_1523
TBA: TERMP_00069 TERMP_00070 TERMP_00536 TERMP_00537
THE: GQS_02470 GQS_02475 GQS_04985 GQS_04990
THA: TAM4_296 TAM4_701 TAM4_99
THM: CL1_0143 CL1_0144 CL1_0643 CL1_0644
TLT: OCC_03062 OCC_03067 OCC_12216 OCC_12221
THS: TES1_0166 TES1_0167
TNU: BD01_0437 BD01_0438 BD01_2067 BD01_2068
TEU: TEU_09725 TEU_09730
TGY: X802_03245 X802_03250 X802_07560 X802_07565
THV: ADU37_CDS02170 ADU37_CDS02180 ADU37_CDS16280 ADU37_CDS16290
TCH: CHITON_0949 CHITON_0950 CHITON_1019 CHITON_1020
TPEP: A0127_05275 A0127_05280 A0127_07135 A0127_07140
TPIE: A7C91_06185 A7C91_06190 A7C91_08725 A7C91_08730
TGG: A3K92_08480 A3K92_08485
TCE: A3L02_00965 A3L02_00970 A3L02_02385 A3L02_02390
TBS: A3L01_00920 A3L01_00925 A3L01_03415 A3L01_03420
THH: CDI07_00920 CDI07_00925 CDI07_03355 CDI07_03360
TSL: A3L11_04675 A3L11_04680 A3L11_07375 A3L11_07380
TTD: A3L14_02375 A3L14_02380 A3L14_05100 A3L14_05105
TPRF: A3L09_05685 A3L09_05690 A3L09_05740 A3L09_05745
TRL: A3L10_03150 A3L10_03155 A3L10_05635 A3L10_05640
TPAF: A3L08_06480 A3L08_06485
THY: A3L12_05480 A3L12_05485
TIC: FH039_02775 FH039_02780 FH039_05970 FH039_05975
TCQ: TIRI35C_0406(shyA) TIRI35C_0407(shyD) TIRI35C_0918(hydA) TIRI35C_0919(hydD)
THEM: FPV09_03375 FPV09_03380 FPV09_06575 FPV09_06580
PPAC: PAP_01490 PAP_01495 PAP_03250 PAP_03255
MCJ: MCON_3103(nuoF)
HUT: Huta_2099 Huta_2604 Huta_2605
HTI: HTIA_1871 HTIA_2365
HALA: Hrd1104_08655 Hrd1104_08660
HDS: HSR122_2937(frhA)
HARC: HARCEL1_01230
HDF: AArcSl_2420 AArcSl_2421
ABI: Aboo_0080 Aboo_0081
ACF: AciM339_0970 AciM339_0971
THG: TCELL_1052 TCELL_1053
FFO: FFONT_1018 FFONT_1019
NCV: NCAV_0543 NCAV_0544
CSU: CSUB_C1023
KCR: Kcr_0321 Kcr_0322
BARB: AOA66_1503(shyD) AOA66_1504(hydA)
LOKI: Lokiarch_31190
PSYT: DSAG12_03219(shyD)
AGW: QT03_C0001G0117 QT03_C0001G0118
 » show all
Reference
1  [PMID:9703971]
  Authors
de Luca G, de Philip P, Rousset M, Belaich JP, Dermoun Z
  Title
The NADP-reducing hydrogenase of Desulfovibrio fructosovorans: evidence for a native complex with hydrogen-dependent methyl-viologen-reducing activity.
  Journal
Biochem Biophys Res Commun 248:591-6 (1998)
DOI:10.1006/bbrc.1998.9022
  Sequence
[ag:AAA87054 AAA87055 AAA87056 AAA87057]
Reference
2  [PMID:2538471]
  Authors
Bryant FO, Adams MW
  Title
Characterization of hydrogenase from the hyperthermophilic archaebacterium, Pyrococcus furiosus.
  Journal
J Biol Chem 264:5070-9 (1989)
  Sequence
[pfu:PF0894 PF0893]
Reference
3  [PMID:8389482]
  Authors
Ma K, Schicho RN, Kelly RM, Adams MW
  Title
Hydrogenase of the hyperthermophile Pyrococcus furiosus is an elemental sulfur reductase or sulfhydrogenase: evidence for a sulfur-reducing hydrogenase ancestor.
  Journal
Proc Natl Acad Sci U S A 90:5341-4 (1993)
DOI:10.1073/pnas.90.11.5341
Reference
4
  Authors
Ma, K., Zhou, Z.H. and Adams, M.W.
  Title
Hydrogen production from pyruvate by enzymes purified from the hyperthermophilic archaeon, Pyrococcus furiosus: A key role for NADPH.
  Journal
FEMS Microbiol Lett 122:245-250 (1994)
Reference
5  [PMID:18156274]
  Authors
van Haaster DJ, Silva PJ, Hagedoorn PL, Jongejan JA, Hagen WR
  Title
Reinvestigation of the steady-state kinetics and physiological function of the soluble NiFe-hydrogenase I of Pyrococcus furiosus.
  Journal
J Bacteriol 190:1584-7 (2008)
DOI:10.1128/JB.01562-07
Other DBs
ExplorEnz - The Enzyme Database: 1.12.1.3
IUBMB Enzyme Nomenclature: 1.12.1.3
ExPASy - ENZYME nomenclature database: 1.12.1.3
BRENDA, the Enzyme Database: 1.12.1.3
CAS: 9027-05-8
LinkDB

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