| Entry |
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| Name |
anthranilate 3-monooxygenase (deaminating);
anthranilate hydroxylase;
anthranilate 2,3-dioxygenase (deaminating);
anthranilate hydroxylase (deaminating);
anthranilic hydroxylase;
anthranilate 2,3-hydroxylase (deaminating)
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)
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| Reaction(IUBMB) |
anthranilate + NADPH + H+ + O2 = 2,3-dihydroxybenzoate + NADP+ + NH3 [RN: R00980]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme from Aspergillus niger is an iron protein; that from the yeast Trichosporon cutaneum is a flavoprotein (FAD).
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| History |
EC 1.14.13.35 created 1972 as EC 1.14.12.2, transferred 1990 to EC 1.14.13.35
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| Pathway |
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| Reference |
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| Authors |
Powlowski JB, Dagley S, Massey V, Ballou DP. |
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| Title |
Properties of anthranilate hydroxylase (deaminating), a flavoprotein from Trichosporon cutaneum. |
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| Journal |
J Biol Chem 262:69-74 (1987) |
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| Reference |
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| Authors |
Subramanian V, Vaidyanathan CS. |
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| Title |
Anthranilate hydroxylase from Aspergillus niger: new type of NADPH-linked nonheme iron monooxygenase. |
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| Journal |
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| Other DBs |
| UM-BBD (Biocatalysis/Biodegradation Database): | 1.14.13.35 |
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| LinkDB |
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