KEGG   ENZYME: 1.14.14.101
Entry
EC 1.14.14.101              Enzyme                                 
Name
dihydrochelirubine 12-monooxygenase;
dihydrochelirubine 12-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
dihydrochelirubine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12-hydroxylating)
Reaction(IUBMB)
dihydrochelirubine + [reduced NADPH---hemoprotein reductase] + O2 = 12-hydroxydihydrochelirubine + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R04708]
Reaction(KEGG)
R04708
Substrate
dihydrochelirubine [CPD:C05194];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
12-hydroxydihydrochelirubine [CPD:C05193];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein from the plant Thalictrum bulgaricum.
History
EC 1.14.14.101 created 1999 as EC 1.14.13.57, transferred 2018 to EC 1.14.14.101
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Reference
1
  Authors
Kammerer L, De-Eknamkul W, Zenk MH.
  Title
Enzymic 12-hydroxylation and 12-O-methylation of dihydrochelirubine in dihydromacarpine formation by Thalictrum bulgaricum.
  Journal
Phytochemistry 36:1409-1416 (1994)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.101
IUBMB Enzyme Nomenclature: 1.14.14.101
ExPASy - ENZYME nomenclature database: 1.14.14.101
BRENDA, the Enzyme Database: 1.14.14.101
CAS: 158736-41-5
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