KEGG   ENZYME: 1.14.14.103
Entry
EC 1.14.14.103              Enzyme                                 
Name
tabersonine 16-hydroxylase;
tabersonine-11-hydroxylase;
T11H;
CYP71D12 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
tabersonine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (16-hydroxylating)
Reaction(IUBMB)
tabersonine + [reduced NADPH---hemoprotein reductase] + O2 = 16-hydroxytabersonine + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R05855]
Reaction(KEGG)
R05855
Substrate
tabersonine [CPD:C09244];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
16-hydroxytabersonine [CPD:C11643];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein from the plant Madagascar periwinkle (Catharanthus roseus).
History
EC 1.14.14.103 created 2002 as EC 1.14.13.73, transferred 2018 to EC 1.14.14.103
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12696  tabersonine 16-hydroxylase
Reference
1  [PMID:12228585]
  Authors
St-Pierre B, De Luca V.
  Title
A Cytochrome P-450 Monooxygenase Catalyzes the First Step in the Conversion of Tabersonine to Vindoline in Catharanthus roseus.
  Journal
Plant Physiol 109:131-139 (1995)
DOI:10.1104/pp.109.1.131
  Sequence
[ag:CAB56503]
Reference
2  [PMID:24108213]
  Authors
Besseau S, Kellner F, Lanoue A, Thamm AM, Salim V, Schneider B, Geu-Flores F, Hofer R, Guirimand G, Guihur A, Oudin A, Glevarec G, Foureau E, Papon N, Clastre M, Giglioli-Guivarc'h N, St-Pierre B, Werck-Reichhart D, Burlat V, De Luca V, O'Connor SE, Courdavault V
  Title
A pair of tabersonine 16-hydroxylases initiates the synthesis of vindoline in an  organ-dependent manner in Catharanthus roseus.
  Journal
Plant Physiol 163:1792-803 (2013)
DOI:10.1104/pp.113.222828
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.103
IUBMB Enzyme Nomenclature: 1.14.14.103
ExPASy - ENZYME nomenclature database: 1.14.14.103
BRENDA, the Enzyme Database: 1.14.14.103
CAS: 250378-34-8
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