KEGG   ENZYME: 1.14.14.127
Entry
EC 1.14.14.127              Enzyme                                 

Name
methyl farnesoate epoxidase;
CYP15A1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
methyl (2E,6E)-farnesoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
methyl (2E,6E)-farnesoate + [reduced NADPH---hemoprotein reductase] + O2 = juvenile hormone III + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R08148]
Reaction(KEGG)
R08148
Substrate
methyl (2E,6E)-farnesoate [CPD:C16503];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
juvenile hormone III [CPD:C09694];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in insects except for Lepidoptera (moths and butterflies) is specific for methyl farnesoate (cf. EC 1.14.14.128, farnesoate epoxidase) [1,2].
History
EC 1.14.14.127 created 2015 as EC 1.14.13.202, transferred 2018 to EC 1.14.14.127
Pathway
ec00981  Insect hormone biosynthesis
Orthology
K14937  methyl farnesoate epoxidase / farnesoate epoxidase
Genes
AGA: AgaP_AGAP005658
AAG: 5573424
AALB: 109400580 109404918
CQU: CpipJ_CPIJ014944
AME: 551179 551632
BIM: 100741407
BTER: 100642209
CCAL: 108622763 108626525 108628064
OBB: 114880426 114882699
SOC: 105193715 105201474
MPHA: 105834547
TCA: 658858(CYP15A1)
DPA: 109538052
ATD: 109600030
NVL: 108561482
BMOR: 100286798(P450)
BMAN: 114249593
PMAC: 106719118
PRAP: 110999807
HAW: 110370071
TNL: 113496128
PXY: 105393482
DNX: 107173974
BTAB: 109037742
CLEC: 106662678
ZNE: 110840507
 » show all
Reference
1  [PMID:15024118]
  Authors
Helvig C, Koener JF, Unnithan GC, Feyereisen R
  Title
CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata.
  Journal
Proc Natl Acad Sci U S A 101:4024-9 (2004)
DOI:10.1073/pnas.0306980101
  Sequence
Reference
2  [PMID:23586995]
  Authors
Daimon T, Shinoda T
  Title
Function, diversity, and application of insect juvenile hormone epoxidases (CYP15).
  Journal
Biotechnol Appl Biochem 60:82-91 (2013)
DOI:10.1002/bab.1058
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.127
IUBMB Enzyme Nomenclature: 1.14.14.127
ExPASy - ENZYME nomenclature database: 1.14.14.127
BRENDA, the Enzyme Database: 1.14.14.127
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