Entry
Name
deoxysarpagine hydroxylase;
DOSH
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
10-deoxysarpagine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (10-hydroxylating)
Reaction(IUBMB)
10-deoxysarpagine + [reduced NADPH---hemoprotein reductase] + O2 = sarpagine + [oxidized NADPH---hemoprotein reductase] + H2O [RN:
R05828 ]
Reaction(KEGG)
Substrate
10-deoxysarpagine [CPD:
C11635 ];
[reduced NADPH---hemoprotein reductase] [CPD:
C03024 ];
O2 [CPD:
C00007 ]
Product
sarpagine [CPD:
C09239 ];
[oxidized NADPH---hemoprotein reductase] [CPD:
C03161 ];
H2O [CPD:
C00001 ]
Comment
A cytohrome P-450 (heme-thiolate) protein isolated from the plant Rauvolfia serpentina.
History
EC 1.14.14.136 created 2005 as EC 1.14.13.91, transferred 2018 to EC 1.14.14.136
Pathway
ec00901 Indole alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Reference
Authors
Yu B, Ruppert M, Stockigt J.
Title
Deoxysarpagine hydroxylase--a novel enzyme closing a short side pathway of alkaloid biosynthesis in Rauvolfia.
Journal
Other DBs
LinkDB
All DBs