EC 18.104.22.168 Enzyme
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
sophoraflavanone-B,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2'-hydroxylating)
sophoraflavanone B + [reduced NADPH---hemoprotein reductase] + O2 = leachianone G + [oxidized NADPH---hemoprotein reductase] + H2O [RN:
sophoraflavanone B [CPD:
[reduced NADPH---hemoprotein reductase] [CPD:
leachianone G [CPD:
[oxidized NADPH---hemoprotein reductase] [CPD:
A membrane-bound cytochrome P-450 (heme-thiolate) protein that is associated with the endoplasmic reticulum [1,2]. This enzyme is specific for sophoraflavanone B as substrate. Along with EC
(naringenin 8-dimethylallyltransferase) and EC
(leachianone G 2''-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone G biosynthetic pathway.
EC 22.214.171.124 created 2007 asEC 126.96.36.199, transferred 2018 to EC 188.8.131.52
Yamamoto H, Yatou A, Inoue K.
8-dimethylallylnaringenin 2'-hydroxylase, the crucial cytochrome P450 mono-oxygenase for lavandulylated flavanone formation in Sophora flavescens cultured cells.
Phytochemistry 58:671-6 (2001)
Zhao P, Inoue K, Kouno I, Yamamoto H.
Characterization of leachianone G 2"-dimethylallyltransferase, a novel prenyl side-chain elongation enzyme for the formation of the lavandulyl group of sophoraflavanone G in Sophora flavescens Ait. cell suspension cultures.
Plant Physiol 133:1306-13 (2003)
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