KEGG   ENZYME: 1.14.14.35
Entry
EC 1.14.14.35               Enzyme                                 

Name
dimethylsulfone monooxygenase;
sfnG (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
dimethyl sulfone,FMNH2:oxygen oxidoreductase
Reaction(IUBMB)
dimethyl sulfone + FMNH2 + O2 = methanesulfinate + formaldehyde + FMN + H2O [RN:R11457]
Reaction(KEGG)
R11457;
(other) R10203
Substrate
dimethyl sulfone [CPD:C11142];
FMNH2 [CPD:C01847];
O2 [CPD:C00007]
Product
methanesulfinate [CPD:C21398];
formaldehyde [CPD:C00067];
FMN [CPD:C00061];
H2O [CPD:C00001]
Comment
The enzyme, characterized from Pseudomonas spp., is involved in a dimethyl sulfide degradation pathway. It is dependent on NAD(P)H-dependent FMN reductase (EC 1.5.1.38, EC 1.5.1.39, or EC 1.5.1.42), which provides it with reduced FMN. The product, methanesulfinate, is oxidized spontaneously to methanesulfonate in the presence of dioxygen and FMNH2.
History
EC 1.14.14.35 created 2016
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
Orthology
K17228  dimethylsulfone monooxygenase
Genes
LVE: 103079502
KVA: Kvar_2211
KPE: KPK_2268
KPK: A593_25275
KVD: KR75_23185
KVQ: SP68_03925
KLW: DA718_26010
GQU: AWC35_01430 AWC35_20775
EBT: EBL_c27950
PGE: LG71_12025
PSTS: E05_04150
SRL: SOD_c04590(ssuD1)
SERF: L085_01485
SFJ: SAMEA4384070_0605(ssuD_1)
EAME: GXP68_22050(sfnG)
BNG: EH206_08875(sfnG)
LBQ: CKQ53_11005(sfnG)
EAM: EAMY_1802
EAY: EAM_1763(sfnG)
EPE: CI789_08345(sfnG)
PVA: Pvag_pPag30468(sfnG)
PAGG: AL522_01270(sfnG)
XDO: XDD1_2290
XCZ: EBN15_03305(sfnG)
PAE: PA3954
PAEV: N297_4083(sfnG)
PAEI: N296_4083(sfnG)
PAEP: PA1S_05060
PAEM: U769_05070
PAEL: T223_05010
PAEG: AI22_28555
PAEC: M802_4081(sfnG)
PAEO: M801_3949(sfnG)
PCQ: PcP3B5_03690(msuD_1)
PPU: PP_2765
PPF: Pput_2989
PPI: YSA_09828
PPX: T1E_4830
PPUH: B479_08850
PPUT: L483_08705
PPUN: PP4_36350
PSB: Psyr_2280
PSYR: N018_10590
PAMG: BKM19_014245(sfnG)
PFL: PFL_3263(sfnG)
PPRC: PFLCHA0_c32910(ssuD5)
PPRO: PPC_3286
PFS: PFLU_2730
PFC: PflA506_2962(sfnG)
PFB: VO64_0061
PFW: PF1751_v1c23920(sfnG)
PSEM: TO66_17205
PSOS: POS17_2807
PANR: A7J50_2603
AVN: Avin_43560(sfnG)
AVL: AvCA_43560(sfnG)
AVD: AvCA6_43560(sfnG)
ACB: A1S_3306
ABM: ABSDF3433
ABY: ABAYE0182
ABN: AB57_3753
ABB: ABBFA_00174(ssuD_1)
ABX: ABK1_3552
ABZ: ABZJ_03693(sfnG)
ABH: M3Q_40
ABAD: ABD1_32010(msuD)
ABAZ: P795_0895
ABAU: IX87_13545
ABAA: IX88_01310
ACC: BDGL_002772(ssuD)
ACI: ACIAD3471
ARJ: DOM24_13610(sfnG)
AWU: BEN71_18150(sfnG)
ACUM: C9E88_005035(sfnG)
AGU: AS4_42120(sfnG)
AUG: URS_0925
ALW: FOB21_10750(sfnG)
ATN: FM020_00030(sfnG)
ACHI: CDG60_17225(sfnG)
MBAH: HYN46_04830(sfnG)
MPSY: CEK71_11270(sfnG)
MMOB: F6R98_11760(sfnG)
AMAH: DLM_1546
BPS: BPSS0626
BPSE: BDL_3853(sfnG)
BPSM: BBQ_5569(sfnG)
BPSU: BBN_4025(sfnG)
BPSD: BBX_5690(sfnG)
BPK: BBK_3865(sfnG)
BPSH: DR55_4726(sfnG)
BPSA: BBU_5420(sfnG)
BPSO: X996_3806(sfnG)
BUT: X994_3993(sfnG)
BTE: BTH_II1790(msuD)
BTQ: BTQ_5076(sfnG)
BTJ: BTJ_3703(sfnG)
BTZ: BTL_4557(sfnG)
BTD: BTI_5282 BTI_5439(sfnG)
BTV: BTHA_5667(sfnG)
BTHE: BTN_4201(sfnG)
BTHM: BTRA_3892(sfnG)
BTHA: DR62_4242
BTHL: BG87_4533(sfnG)
BOK: DM82_4721(sfnG)
BOC: BG90_5872(sfnG)
BCEN: DM39_6658(sfnG)
BCEW: DM40_5622(sfnG)
BAM: Bamb_6035
BMJ: BMULJ_05428(ssuD)
BMU: Bmul_6103
BMK: DM80_6557(sfnG)
BMUL: NP80_5310(sfnG)
BCED: DM42_6528(sfnG) DM42_6979
BCON: NL30_33785
BLAT: WK25_18320
BTEI: WS51_29635
BPSL: WS57_18435
BMEC: WJ16_19770
BSTG: WT74_18780
BGU: KS03_5784(sfnG)
BGO: BM43_4541(sfnG)
BUK: MYA_5560
BUL: BW21_4931 BW21_5120(sfnG)
PHS: C2L64_48985(sfnG)
PTS: CUJ90_20710(sfnG)
PMEG: FNZ07_17220(sfnG)
CABA: SBC2_37830(sfnG_1) SBC2_81870(sfnG_2)
BHZ: ACR54_01439(rutA)
AMIM: MIM_c34940
AFQ: AFA_17970
ODI: ODI_R2340
PNA: Pnap_0547
AAV: Aave_0878
AAA: Acav_0827
VAM: C4F17_29465(sfnG)
CTES: O987_03200
JAG: GJA_3845
HHF: E2K99_04295(sfnG)
CPRA: CPter91_0263(sfnG)
MEH: M301_2712
MEP: MPQ_1963
AZO: azo1944
AOA: dqs_2099
THK: CCZ27_05555(sfnG)
HHE: HH_1212
HCP: HCN_2034
CCUN: CCUN_1233
CAMY: CSUIS_1650
MLO: mlr5218
SIX: BSY16_4276(sfnG)
NGG: RG540_CH38620(rutA)
BRK: CWS35_10545(sfnG)
AZC: AZC_2665
LNE: FZC33_02435(sfnG)
MDI: METDI4662
MEX: Mext_3663
MCH: Mchl_3956
MPO: Mpop_3950
MNO: Mnod_5009
META: Y590_18090
METD: C0214_20665(sfnG)
METI: DK427_22420(sfnG)
MTEA: DK419_08335(sfnG)
PLEO: OHA_1_00411(rutA_1) OHA_1_02623(rutA_2)
RBM: TEF_14535
LABT: FIU93_02970(rutA)
SPHD: HY78_22620
STAX: MC45_16800
SECH: B18_02810
BCA: BCE_1067
BWW: bwei_4031(msuD)
BMYO: BG05_4927
BMQ: BMQ_3326
BMD: BMD_3331
BMEG: BG04_239(sfnG)
BFD: NCTC4823_00759(rutA)
OIH: OB3078
PBUT: DTO10_17010(sfnG)
PASA: BAOM_0486 BAOM_0680(sfnG) BAOM_2297(sfnG)
AQT: FN924_14660(sfnG)
PSYO: PB01_15265
GRC: GI584_02620(sfnG)
ESI: Exig_2964
EAN: Eab7_2774
PMW: B2K_22565
PPRT: ET464_01465(sfnG) ET464_01485(sfnG)
JEO: JMA_31650
PANC: E2636_17010(sfnG)
TVU: AB849_008395(sfnG)
MMC: Mmcs_4323
MKM: Mkms_4409
MJL: Mjls_4703
MGRO: FZ046_00545(sfnG)
MVA: Mvan_4860
MPHL: MPHLCCUG_00939(msuD_1)
MVQ: MYVA_4692
MTHN: 4412656_00216(ssuD_2) 4412656_00670(rutA_2)
MHAS: MHAS_03377(msuD_2)
MAUU: NCTC10437_04577(rutA_5)
MAB: MAB_1060
MABB: MASS_1052
MCHE: BB28_05290
MSTE: MSTE_01033
MSAL: DSM43276_00934(ssuD_2)
MHIB: MHIB_20000
ASD: AS9A_3912
CTER: A606_09765
NFA: NFA_54330
NFR: ERS450000_04431(ssuD_4)
NTP: CRH09_02040(sfnG)
NOZ: DMB37_19315(sfnG)
NAH: F5544_43660(sfnG)
NAD: NCTC11293_00454(ssuD_1)
RER: RER_55130
REY: O5Y_26275
RHB: NY08_2415
RFA: A3L23_00606(msuD_1)
RHS: A3Q41_02750(msuD_2)
RRZ: CS378_15315(sfnG)
RHU: A3Q40_02630(msuD)
RQI: C1M55_27795(sfnG)
GBR: Gbro_1580
GOC: CXX93_12325(sfnG)
GIT: C6V83_11720(sfnG)
GRU: GCWB2_07865(msuD2)
GOM: D7316_05428(msuD)
GAV: C5O27_19945(sfnG)
GOD: GKZ92_07445(sfnG)
TPR: Tpau_1371
SGB: WQO_07240
SALS: SLNWT_3839
SFI: SFUL_1457
SALU: DC74_8129
SALL: SAZ_41975
SLE: sle_07770(sle_07770)
SGE: DWG14_07843(ssuD_1)
SRJ: SRO_0282
SCYA: EJ357_41465(sfnG)
SAST: CD934_02285(sfnG)
STRI: C7M71_006850(sfnG)
CMI: CMM_1466
CMS: CMS1500
CMC: CMN_01443
MTS: MTES_1548
MOO: BWL13_00504(ssuD)
MLV: CVS47_02927(ssuD)
ART: Arth_0532
ARTP: E5206_00930(sfnG)
PSNI: NIBR502771_02345(sfnG)
PSEY: GU243_19025(sfnG)
BGG: CFK41_03085(sfnG)
BSAU: DWV08_11095(sfnG)
BRR: C1N80_05340(sfnG)
LMOI: VV02_09840
XCE: Xcel_0310
ORN: DV701_11955(sfnG)
ORZ: FNH13_07810(sfnG)
BLIN: BLSMQ_0886
BLUT: EW640_00985(sfnG)
NOI: FCL41_02955(sfnG)
NDP: E2C04_03680(sfnG)
TFU: Tfu_1497
NGV: CDO52_23630(sfnG)
KRA: Krad_3993
SEN: SACE_4062(msuD)
AOI: AORI_1169(ssuD)
AMYC: CU254_04280(sfnG)
AMYY: YIM_27095(ssuD4)
PSEH: XF36_03895
SSYI: EKG83_10470(sfnG)
KAL: KALB_1059
EKE: EK0264_03050(sfnG)
RXY: Rxyl_1784
GVI: gll4257
GLJ: GKIL_4496(ssuD)
NSH: GXM_07450
GES: VT84_29135(msuD)
ACA: ACP_2062(msuD)
ABAS: ACPOL_1673
GAU: GAU_2555
GBA: J421_2046
SRU: SRU_2328
SRM: SRM_02552
FAE: FAES_2004(msuD)
HLA: Hlac_1046
HALN: B4589_006385(sfnG)
 » show all
Reference
1  [PMID:15661012]
  Authors
Endoh T, Habe H, Nojiri H, Yamane H, Omori T.
  Title
The sigma54-dependent transcriptional activator SfnR regulates the expression of  the Pseudomonas putida sfnFG operon responsible for dimethyl sulphone utilization.
  Journal
Mol Microbiol 55:897-911 (2005)
DOI:10.1111/j.1365-2958.2004.04431.x
Reference
2  [PMID:27392454]
  Authors
Wicht DK
  Title
The reduced flavin-dependent monooxygenase SfnG converts dimethylsulfone to methanesulfinate.
  Journal
Arch Biochem Biophys 604:159-66 (2016)
DOI:10.1016/j.abb.2016.07.001
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.35
IUBMB Enzyme Nomenclature: 1.14.14.35
ExPASy - ENZYME nomenclature database: 1.14.14.35
BRENDA, the Enzyme Database: 1.14.14.35
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