KEGG   ENZYME: 1.14.14.91Help
Entry
EC 1.14.14.91               Enzyme                                 

Name
trans-cinnamate 4-monooxygenase;
cinnamic acid 4-hydroxylase;
CA4H;
cytochrome P450 cinnamate 4-hydroxylase;
cinnamate 4-hydroxylase;
cinnamate 4-monooxygenase;
cinnamate hydroxylase;
cinnamic 4-hydroxylase;
cinnamic acid 4-monooxygenase;
cinnamic acid p-hydroxylase;
t-cinnamic acid hydroxylase;
trans-cinnamate 4-hydroxylase;
trans-cinnamic acid 4-hydroxylase;
CYP73A1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
trans-cinnamate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
trans-cinnamate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxycinnamate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R02253]
Reaction(KEGG)
R02253;
(other) R08815
Show
Substrate
trans-cinnamate [CPD:C00423];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
4-hydroxycinnamate [CPD:C00811];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in flavonoid biosynthesis.
History
EC 1.14.14.91 created 1976 as EC 1.14.13.11, transferred 2018 to EC 1.14.14.91
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec00940  Phenylpropanoid biosynthesis
ec00941  Flavonoid biosynthesis
ec00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ec00999  Biosynthesis of secondary metabolites - unclassified
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00487  trans-cinnamate 4-monooxygenase
Genes
ATH: AT2G30490(C4H)
ALY: ARALYDRAFT_481961
CRB: 17888026
CSAT: 104700439 104749839 104786614
EUS: EUTSA_v10016544mg EUTSA_v10016545mg
BRP: 103857322 103857323 103865042 103865043 103867954
BNA: 106348398 106348399 106387868 106387869 106437590 106437591 106446415 106451418 111205796
BOE: 106295375 106329505 106336023 106337156 106342634
RSZ: 108812700 108847879 108848885 108849675
THJ: 104800793 104815827
CPAP: 110823746
CIT: 102577934(C4H1) 102578013(C4H2)
GMX: 100499623(C4H) 100818985
VRA: 106764845
VAR: 108338193
LJA: Lj0g3v0153609.1(Lj0g3v0153609.1) Lj0g3v0343649.1(Lj0g3v0343649.1) Lj5g3v2166250.1(Lj5g3v2166250.1) Lj5g3v2216160.1(Lj5g3v2216160.1) Lj6g3v0351660.1(Lj6g3v0351660.1)
LANG: 109339369
CANN: 107875406(C4H) 107875407
NTA: 107781854(CYP73A27) 107791262(CYP73A47v3) 107812882 107820794(CYP73A28) 107823514(C4H) 107826530(CYP73A47v1)
DOSA: Os02t0467000-00(Os02g0467000) Os02t0467600-01(Os02g0467600) Os05t0320700-02(Os05g0320700)
ATS: 109751434(LOC109751434) 109754216(LOC109754216) 109762639(LOC109762639) 109770341(LOC109770341) 109771714(LOC109771714) 109777191(LOC109777191)
AOF: 109846559
PPP: 112277388
 » show all
Taxonomy
Reference
1  [PMID:4153152]
  Authors
Potts JR, Weklych R, Conn EE, Rowell J.
  Title
The 4-hydroxylation of cinnamic acid by sorghum microsomes and the requirement for cytochrome P-450.
  Journal
J Biol Chem 249:5019-26 (1974)
Reference
2  [PMID:4383827]
  Authors
Russell DW, Conn EE.
  Title
The cinnamic acid 4-hydroxylase of pea seedlings.
  Journal
Arch Biochem Biophys 122:256-8 (1967)
DOI:10.1016/0003-9861(67)90150-6
Reference
3  [PMID:7925408]
  Authors
Pierrel MA, Batard Y, Kazmaier M, Mignotte-Vieux C, Durst F, Werck-Reichhart D
  Title
Catalytic properties of the plant cytochrome P450 CYP73 expressed in yeast. Substrate specificity of a cinnamate hydroxylase.
  Journal
Eur J Biochem 224:835-44 (1994)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.91
IUBMB Enzyme Nomenclature: 1.14.14.91
ExPASy - ENZYME nomenclature database: 1.14.14.91
BRENDA, the Enzyme Database: 1.14.14.91
CAS: 9077-75-2
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