KEGG   ENZYME: 1.14.14.94Help
Entry
EC 1.14.14.94               Enzyme                                 

Name
leukotriene-B4 20-monooxygenase;
leukotriene-B4 20-hydroxylase;
leucotriene-B4 omega-hydroxylase;
LTB4 20-hydroxylase;
LTB4 omega-hydroxylase;
CYP4F2 (gene name);
CYP4F3 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (20-hydroxylating)
Reaction(IUBMB)
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH---hemoprotein reductase] + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R03866]
Reaction(KEGG)
Substrate
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate [CPD:C02165];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate [CPD:C04853];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein found in mammals.
History
EC 1.14.14.94 created 1989 as EC 1.14.13.30, transferred 2018 to EC 1.14.14.94
Pathway
ec00590  Arachidonic acid metabolism
Orthology
K17726  phylloquinone omega-hydroxylase / docosahexaenoic acid omega-hydroxylase / leukotriene-B4 20-monooxygenase
Genes
HSA: 4051(CYP4F3) 8529(CYP4F2)
PTR: 100609185 748117(CYP4F3) 748531(CYP4F2)
PPS: 100967411 100969141 100969847 100982619
GGO: 101125692 101135418 101151919 101152881
PON: 100434096 100437847 100453229 100459978
NLE: 100579320 100588006 100592938 115836968
MCC: 718349 719317
MCF: 102120579 102130440(CYP4F3v2) 102134301(CYP4F45)
CSAB: 103234079 103234089
RRO: 104661012 104661014 104661137
RBB: 108543258 108543262 108543288 108543294
CJC: 100411160 100412575(CYP4F2)
SBQ: 101042165 101050944 101051361
MMU: 170716(Cyp4f13) 64385(Cyp4f14) 72054(Cyp4f18)
MCAL: 110284019 110299801 110312354 110312365 110312367 110312474
MPAH: 110335560 110335593 110335977 110336552
RNO: 266689(Cyp4f6) 290623(Cyp4f18) 56266(Cyp4f1)
MUN: 110548892 110548901 110548904 110558734 110564919 110564920
CGE: 100761725 100773031 100774306 100774594
NGI: 103731633 103736430
HGL: 101696402 101697745 101726538
CCAN: 109687406 109687410 109687414 109687418 109687419 109687420 109689048
OCU: 100348038 100350957 100351457 100351707 100356924
TUP: 102469250 102469432 102469671 102483333
CFA: 484867
VVP: 112913138 112913139
AML: 100472069 100472316 105234748
UMR: 103677173 103677174
UAH: 113248719 113256587
ORO: 101377045 101383601
ELK: 111143816 111143817
FCA: 105259722
PTG: 102971715 102972201
PPAD: 109247523 109247524
AJU: 106987569
BTA: 100295883 507016(CYP4F2) 507615(CYP4F2) 509506 534967
BOM: 102286314 102286596 102286889 102287174 102287641
BIU: 109561472 109561473 109561475 109561476
BBUB: 102410162 102411446 102411985 102412989 102413949 102414504
CHX: 102181586 102181858 102182119 102183680 102186759 102187311
OAS: 101118184 101118441 101122521 105613870 106990140 443099(CYP4F21)
SSC: 100113470(CYP4F2) 100620559(CYP4F55) 110259329
CFR: 102519376 102519624
CDK: 105105133
LVE: 103089103
OOR: 101275454 101275866
DLE: 111166561 111166705
PCAD: 102984625 102984916
ECB: 100062102 100070123 100070143 100070707 100147344 111769620
EPZ: 103542412 103544569
EAI: 106831784 106831785 106839059 106844132 106846853
MYB: 102257438
MYD: 102765771
MNA: 107534280 107534281
HAI: 109376058
DRO: 112305042 112305133
RAY: 107517263 107517264
MJV: 108403982 108405812 108408757 108410041
LAV: 100657544 100657832 100658973 100659260 100659544
TMU: 101354704 101355377
MDO: 100013359 100013399 100013494
SHR: 100913664 100922197 111719596
PCW: 110196196 110196228
PHI: 102108727
DRE: 100037390(cyp4f3)
SRX: 107715173
SANH: 107688049
SGH: 107597750
CCAR: 109105400
IPU: 108274321(CYP4F66)
PHYP: 113527727
AMEX: 103027280 103035198
EEE: 113590686
TRU: 101071805
TNG: GSTEN00012897G001 GSTEN00031830G001
LCO: 104935050
NCC: 104952154
MZE: 101469132 101474973
ONL: 100711688 100711960 100712228 100712495
OLA: 101170499
XMA: 102221417
XCO: 114141248
PRET: 103474609
CVG: 107095728 107102428
NFU: 107380885
KMR: 108246779
ALIM: 106525713
AOCE: 111580294
POV: 109644290
LCF: 108892835
SDU: 111236695
SLAL: 111665305
HCQ: 109528684
BPEC: 110153255
MALB: 109960560
SASA: 106577419 106592262(CP4F3)
ELS: 105009756
SFM: 108930167
PKI: 111834641
BFO: BRAFLDRAFT_57349
LGI: LOTGIDRAFT_237658
LAK: 106155350
PSQ: PUNSTDRAFT_119044
FME: FOMMEDRAFT_138337
 » show all
Taxonomy
Reference
1  [PMID:3027095]
  Authors
Romano MC, Eckardt RD, Bender PE, Leonard TB, Straub KM, Newton JF.
  Title
Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases.
  Journal
J Biol Chem 262:1590-5 (1987)
Reference
2  [PMID:4044832]
  Authors
Shak S, Goldstein IM.
  Title
Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Partial purification and identification as a cytochrome P-450.
  Journal
J Clin Invest 76:1218-28 (1985)
DOI:10.1172/JCI112077
Reference
3  [PMID:2986111]
  Authors
Soberman RJ, Harper TW, Murphy RC, Austen KF.
  Title
Identification and functional characterization of leukotriene B4 20-hydroxylase of human polymorphonuclear leukocytes.
  Journal
Proc Natl Acad Sci U S A 82:2292-5 (1985)
DOI:10.1073/pnas.82.8.2292
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.94
IUBMB Enzyme Nomenclature: 1.14.14.94
ExPASy - ENZYME nomenclature database: 1.14.14.94
BRENDA, the Enzyme Database: 1.14.14.94
CAS: 90119-11-2
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