Entry |
|
Name |
iodotyrosine deiodinase;
iodotyrosine dehalogenase 1;
DEHAL1
|
Class |
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y
|
Sysname |
L-tyrosine,iodide:NADP+ oxidoreductase (iodinating)
|
Reaction(IUBMB) |
L-tyrosine + 2 NADP+ + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ (overall reaction) [RN: R10059];
(1a) L-tyrosine + NADP+ + iodide = 3-iodo-L-tyrosine + NADPH + H+ [RN: R09521];
(1b) 3-iodo-L-tyrosine + NADP+ + iodide = 3,5-diiodo-L-tyrosine + NADPH + H+ [RN: R09522]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
|
Comment |
The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein. Requires FMN.
|
History |
EC 1.21.1.1 created 2010 as EC 1.22.1.1 transfered 2015 to EC 1.21.1.1
|
Orthology |
K17231 | iodotyrosine deiodinase |
|
Genes |
» show all
|
Reference |
|
Authors |
Rosenberg IN |
Title |
Purification of iodotyrosine deiodinase from bovine thyroid. |
Journal |
|
Reference |
|
Authors |
Gnidehou S, Caillou B, Talbot M, Ohayon R, Kaniewski J, Noel-Hudson MS, Morand S, Agnangji D, Sezan A, Courtin F, Virion A, Dupuy C |
Title |
Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Friedman JE, Watson JA Jr, Lam DW, Rokita SE |
Title |
Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamily. |
Journal |
|
Reference |
|
Authors |
Thomas SR, McTamney PM, Adler JM, Laronde-Leblanc N, Rokita SE |
Title |
Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands. |
Journal |
|
Sequence |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 1.21.1.1 |
ExPASy - ENZYME nomenclature database: | 1.21.1.1 |
|
LinkDB |
|