KEGG ENZYME: 1.21.1.1

ENZYME: 1.21.1.1

Entry

EC 1.21.1.1                 Enzyme

Name

iodotyrosine deiodinase;
iodotyrosine dehalogenase 1;
DEHAL1

Class

Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With NAD+ or NADP+ as acceptor

Sysname

L-tyrosine,iodide:NADP+ oxidoreductase (iodinating)

Reaction(IUBMB)

L-tyrosine + 2 NADP+ + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ (overall reaction) [RN:R10059];
(1a) L-tyrosine + NADP+ + iodide = 3-iodo-L-tyrosine + NADPH + H+ [RN:R09521];
(1b) 3-iodo-L-tyrosine + NADP+ + iodide = 3,5-diiodo-L-tyrosine + NADPH + H+ [RN:R09522]

Reaction(KEGG)

R09521 R09522 R10059

Substrate

L-tyrosine [CPD:C00082];
NADP+ [CPD:C00006];
iodide [CPD:C00708];
3-iodo-L-tyrosine [CPD:C02515]

Product

3,5-diiodo-L-tyrosine [CPD:C01060];
NADPH [CPD:C00005];
H+ [CPD:C00080];
3-iodo-L-tyrosine [CPD:C02515]

Comment

The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein. Requires FMN.

History

EC 1.21.1.1 created 2010 as EC 1.22.1.1, transferred 2015 to EC 1.21.1.1

Orthology

K17231

iodotyrosine deiodinase

Genes

HSA:	389434(IYD)

PTR:	472159(IYD)

PPS:	100984862(IYD)

GGO:	101134826(IYD)

PON:	100127058(IYD)

PPYG:

129039347(IYD)

NLE:	100604496(IYD)

HMH:	116463172 116463224

SSYN:

129463478(IYD)

MCC:	705471(IYD)

MCF:	102137987(IYD)

MTHB:

126952026

MNI:	105489031(IYD)

CSAB:

103240719(IYD)

CATY:

105588842(IYD)

PANU:

101015685(IYD)

TGE:	112623070(IYD)

MLEU:

105545702(IYD)

RRO:	104678344(IYD)

RBB:	108539141(IYD)

TFN:	117097274(IYD)

PTEH:

111538483(IYD)

CANG:

105513031(IYD)

CJC:	100414973(IYD)

SBQ:	101036070(IYD)

CIMI:

108311689(IYD)

ANAN:

105717273(IYD)

CSYR:

103260107(IYD)

MMUR:

105858073(IYD)

LCAT:

123633369(IYD)

PCOQ:

105819362(IYD)

OGA:	100957357(IYD)

MMU:	70337(Iyd)

MCAL:

110303822(Iyd)

MPAH:

110338417(Iyd)

RNO:	308129(Iyd)

MCOC:

116077755(Iyd)

ANU:	117700296(Iyd)

ASYL:

127674088(Iyd)

MUN:	110563030(Iyd)

CGE:	100766759(Iyd)

MAUA:

101823963(Iyd)

PROB:

127237657(Iyd)

PLEU:

114683852(Iyd)

MORG:

121466468(Iyd)

MFOT:

126497635

AAMP:

119821335(Iyd)

NGI:	103745746(Iyd)

HGL:	101721889(Iyd)

CPOC:

100716898 100728406(Iyd)

CCAN:

109694205(Iyd)

DORD:

105993643(Iyd)

DSP:	122114986(Iyd)

DMER:

138819407(Iyd)

PLOP:

125357405(Iyd)

NCAR:

124988740

MMMA:

107156179(Iyd)

ITI:	101974736(Iyd)

OCU:	100353029 127492945

OPI:	101524209(IYD)

TUP:	102468639(IYD)

GVR:	103606704(IYD)

CFA:	476244(IYD)

CLUD:

112644299(IYD)

VVP:	112919440(IYD)

VLG:	121485856(IYD)

NPO:	129499742(IYD)

AML:	100476845(IYD)

UMR:	103666913(IYD)

UAH:	113259558(IYD)

UAR:	123797449(IYD)

ELK:

111158731

LLV:

125103057

MPUF:

101686844(IYD)

MNP:	132017504(IYD)

MLK:	131833462(IYD)

NVS:	122903319(IYD)

ORO:	101373266(IYD)

EJU:	114209346(IYD)

ZCA:	113927271(IYD)

MLX:	118001518(IYD)

NSU:	110583371(IYD)

LWW:	102747672(IYD)

FCA:	101100136(IYD)

PYU:	121013320(IYD)

PCOO:

112862424(IYD)

PBG:	122490094(IYD)

PVIV:

125166389(IYD)

LRUF:

124527950

LGF:	123609167(IYD)

AJU:

106976275

PTG:	102961413(IYD)

PPAD:

109256433(IYD)

PUC:

125938034

PLEZ:

122220491(IYD)

HHV:	120237577(IYD)

BTA:	534110(IYD)

BOM:	102270351(IYD)

BIU:	109564048(IYD)

BBUB:

102415802(IYD)

BBIS:

104989207(IYD)

CHX:	102171610(IYD)

OAS:	101123564(IYD)

BTAX:

128053492(IYD)

CSUM:

138089682(IYD)

ODA:	120862613(IYD)

CCAD:

122434198(IYD)

MREE:

136165139(IYD)

OVR:	110133961(IYD)

MBEZ:

129561212(IYD)

SSC:	403124(IYD)

CFR:	102518380(IYD)

CBAI:

105077321(IYD)

CDK:	105100920(IYD)

VPC:	102531075(IYD)

BACU:

103018668(IYD)

BMUS:

118905526(IYD)

LVE:	103070559(IYD)

OOR:	101281121(IYD)

LALB:

132530658(IYD)

GMF:	115851170(IYD)

DDP:	132436846(IYD)

DLE:	111169022(IYD)

PCAD:

102982392(IYD)

PSIU:

116763481(IYD)

PPHC:

136132075(IYD)

NASI:

112401613(IYD)

ECB:	100147582(IYD)

EPZ:	103548978(IYD)

EAI:	106837202(IYD)

MYB:	102251589(IYD)

MYD:	102768666(IYD)

MMYO:

118660546(IYD)

MLF:	102428749(IYD)

MDT:	132236782(IYD)

MYUM:

139012088(IYD)

PKL:	118705830(IYD)

EFUS:

103301591(IYD)

MNA:	107535960(IYD)

DRO:	112297121(IYD)

SHON:

118988825(IYD)

AJM:	119057916(IYD)

PDIC:

114495485(IYD)

PHAS:

123821741(IYD)

MMF:	118621798(IYD)

PPAM:

129067251(IYD)

HAI:	109380862(IYD)

RFQ:	117015693(IYD)

PALE:

102879253(IYD)

PGIG:

120593475(IYD)

PVP:	105293822(IYD)

RAY:	107513019(IYD)

MJV:	108405632(IYD)

TOD:	119253491(IYD)

SARA:

101549865(IYD)

SFUM:

130034615(IYD)

SETR:

125996472(IYD)

LAV:	100655124(IYD)

TMU:

101346269

ETF:	101639086(IYD)

DNM:	101433207(IYD)

MDO:	100032091(IYD)

GAS:	123245732(IYD)

SHR:	100913424(IYD)

AFZ:

127562324

PCW:	110208654(IYD)

TVP:	118858059(IYD)

PBRV:

138147290(IYD)

MLAO:

141488084(IYD)

OAA:	100074313(IYD)

TACU:

119945763(IYD)

GGA:	421631(IYD)

PCOC:

116243017(IYD)

MGP:	100542007(IYD)

CJO:	107311580(IYD)

TPAI:

128079349(IYD)

LMUT:

125689237(IYD)

NMEL:

110396831(IYD)

APLA:

101792350(IYD)

ACYG:

106034300(IYD)

CATA:

118244153(IYD)

AFUL:

116487842(IYD)

TGU:	100219876(IYD)

LSR:	110476008(IYD)

SCAN:

103820571(IYD)

PMOA:

120501310(IYD)

OTC:	121346317(IYD)

PRUF:

121354985(IYD)

ATRC:

139594059(IYD)

GFR:	102034470(IYD)

FAB:	101817326(IYD)

OMA:	130251224(IYD)

PHI:	102107342(IYD)

PMAJ:

107202547(IYD)

CCAE:

111926697(IYD)

CCW:	104690271(IYD)

CBRC:

103619342(IYD)

ACOE:

138108263(IYD)

ETL:	114061120(IYD)

ZAB:	102064528(IYD)

ZLE:	135444870(IYD)

ACHL:

103808325(IYD)

SVG:	106851925(IYD)

MMEA:

130572628(IYD)

HRT:	120750575(IYD)

SATI:

136359129(IYD)

CCIC:

134041847(IYD)

FPG:	101919057(IYD)

FCH:	102046732(IYD)

CCRI:

104167350(IYD)

NNT:	104402773(IYD)

SHAB:

115613955(IYD)

ACUN:

113478457(IYD)

TALA:

104363809(IYD)

ACHC:

115345036(IYD)

HALD:

104317473(IYD)

HLE:	104840730(IYD)

AGEN:

126038891

HHAR:

128140616(IYD)

GCL:

127014566

CSTI:

104561351(IYD)

LDI:	104352925(IYD)

MNB:	103780854(IYD)

DPUB:

104297159(IYD)

PPUS:

135189192(IYD)

AVIT:

104279355(IYD)

BRHI:

104489698(IYD)

EGZ:	104133538(IYD)

NNI:	104013770(IYD)

PCRI:

104036573(IYD)

PCAO:

104043584(IYD)

PADL:

103917035(IYD)

AFOR:

103900683(IYD)

FGA:	104079928(IYD)

GSTE:

104264383(IYD)

CBOY:

140650067(IYD)

CLV:	102093624(IYD)

CNIC:

135987128(IYD)

MUI:	104546395(IYD)

PGUU:

104457856(IYD)

PLET:

104628627(IYD)

EHS:	104502723(IYD)

CMAC:

104487099(IYD)

CUCA:

104056890(IYD)

TEO:	104374148(IYD)

BREG:

104636067(IYD)

OHA:	104328691(IYD)

ACAR:

104517417(IYD)

CPEA:

104390771(IYD)

CVF:	104285577(IYD)

RTD:	128906701(IYD)

CRID:

134513863(IYD)

AAM:	106496910(IYD)

AROW:

112974629(IYD)

NPD:	112951677(IYD)

TGT:	104574304(IYD)

DNE:	112989876(IYD)

SCAM:

104151185(IYD)

ASN:	102382246(IYD)

AMJ:	102570232(IYD)

CPOO:

109319118(IYD)

GGN:	109304792(IYD)

PSS:	102454348(IYD)

CMY:	102935978(IYD)

CCAY:

125634069(IYD)

DCC:	119853328(IYD)

CPIC:

101948894(IYD)

TST:	117874844(IYD)

CABI:

116828690(IYD)

MRV:	120400077(IYD)

ACS:	100566819(iyd)

ASAO:

132761055(IYD)

PVT:	110086269(IYD)

SUND:

121935250(IYD)

PBI:	103056683(IYD)

PMUR:

107287409(IYD)

CTIG:

120309504(IYD)

TSR:	106551518(IYD)

PGUT:

117666407(IYD)

PCAE:

139322706(IYD)

APRI:

131188523(IYD)

PTEX:

113439526(IYD)

NSS:	113411251(IYD)

VKO:	123032719(IYD)

PMUA:

114594248(IYD)

PRAF:

128410652(IYD)

ZVI:	118082013(IYD)

HCG:	128343387(IYD)

GJA:	107109504(IYD)

STOW:

125438843(IYD)

EMC:	129340828(IYD)

XLA:	447152(iyd.L)

XTR:	496718(iyd)

NPR:	108797441(IYD)

RTEM:

120937544(IYD)

ACAT:

141140509(IYD)

BBUF:

120998726(IYD)

BGAR:

122935780(IYD)

DTC:	141063546(IYD)

PWL:	138295777(IYD)

MUO:	115465107(IYD)

GSH:	117357876(IYD)

DRE:	100330940(iyd)

SRX:	107738503 107754896

SANH:

107697889

SGH:	107558720 107590463(iyd)

CCAR:

109057743 109060687(iyd)

CAUA:

113041286(iyd)

CGIB:

127944344 128011906

PTET:

122332842(iyd)

LROH:

127154392(iyd)

OMC:	131532319(iyd)

PPRM:

120462822 120462905

RKG:	130076221(iyd)

MAMB:

125260648(iyd)

CIDE:

127504638

CERY:

137009369(iyd)

MASI:

127420003

TROS:

130544966(iyd)

TDW:	130409505(iyd)

MANU:

129430565(iyd)

PDAB:

135775170(iyd)

IPU:

108275850

IFU:	128619176(iyd)

PHYP:

113530659(iyd)

SMEO:

124399130(iyd)

TFD:	113641913(iyd)

TVC:	132862352(iyd)

CGAR:

128509972(iyd)

NGRA:

132896070(iyd)

TRN:	134333347(iyd)

AMEX:

103036643(iyd)

CMAO:

118822163(iyd)

EEE:	113570295(iyd)

CHAR:

105904203(iyd)

SPIL:

134098372(iyd)

TRU:	101074588(iyd)

TFS:	130516204(iyd)

TNG:	GSTEN00030259G001

LCO:	104923576(iyd)

NCC:	104950033(iyd)

TBEN:

117492848(iyd)

CGOB:

115003559(iyd)

PGEO:

117440320(iyd)

GACU:

117558082(iyd)

EMAC:

134876793(iyd)

ELY:	117271296(iyd)

EFO:	125897218(iyd)

PLEP:

121955913(iyd)

SLUC:

116066096(iyd)

ECRA:

117961869(iyd)

ESP:	116706620(iyd)

PFLV:

114572951(iyd)

GAT:	120807832(iyd)

PPUG:

119194718(iyd)

AFB:	129107360(iyd)

CLUM:

117727174(iyd)

PSWI:

130202647(iyd)

CANA:

137786026(iyd)

CVE:	137870813(iyd)

MSAM:

119908879(iyd)

SCHU:

122863387(iyd)

CUD:	121521564(iyd)

SPUL:

138585398(iyd)

LMIX:

132985119(iyd)

ALAT:

119012262(iyd)

ASTR:

137613789(iyd)

MZE:	101464367(iyd)

ONL:	100692784(iyd)

OAU:	116309605(iyd)

OLA:	111947100(iyd)

OML:	112157624(iyd)

CSAI:

133464717(iyd)

XMA:	102217045(iyd)

XCO:	114158612(iyd)

XHE:	116734152(iyd)

PRET:

103457674(iyd)

PFOR:

103138680(iyd)

PLAI:

106945812(iyd)

PMEI:

106922266(iyd)

GAF:	122825896(iyd)

PPRL:

129351200 129369104

CVG:	107097376(iyd)

CTUL:

119788359(iyd)

GMU:	124882016(iyd)

NFU:	107395153(iyd)

KMR:	108242444(iyd)

ALIM:

106520064(iyd)

NWH:	119418150(iyd)

AOCE:

111587259(iyd)

EJA:	138203466(iyd)

BFRE:

138635871(iyd)

MCEP:

124999133(iyd)

CSEM:

103381076(iyd)

POV:	109632477(iyd)

SSEN:

122783789(iyd)

SSOE:

131443168(iyd)

HHIP:

117758799(iyd)

HSP:	118099207(iyd)

SMAU:

118289784(iyd)

LCF:

108896829

SDU:	111216311(iyd)

SLAL:

111651202(iyd)

XGL:	120789124(iyd)

HCQ:	109531800(iyd)

SSCV:

125990443(iyd)

SBIA:

133496683(iyd)

PEE:	133417215(iyd)

PTAO:

133468010(iyd)

BPEC:

110156123(iyd)

ENY:	140356589(iyd)

MALB:

109973854(iyd)

BSPL:

114849767(iyd)

SJO:	128377423(iyd)

SSCO:

133997827(iyd)

GMH:	115534035(iyd)

SASA:

106608372(iyd)

STRU:

115208556(iyd)

OTW:

112237839

OMY:	110510494(iyd)

OGO:	123995482(iyd)

OKI:	109885542(iyd)

OKE:	118380613(iyd)

OMM:	135558018(iyd)

OCLA:

139396221 139396585 139407922

SALP:

111959178(iyd)

SNH:	120035904(iyd)

CCLU:

121556985(iyd)

ELS:	105017989(iyd)

OEP:	134024885(iyd)

SFM:	108920896(iyd)

PKI:	111841144(iyd)

AANG:

118229805(iyd)

AROT:

135257658(iyd)

CCOG:

133129417(iyd)

LOC:	102694335(iyd)

PSPA:

121316996(iyd)

ARUT:

117410625(iyd)

PSEX:

120516831(iyd)

LCM:	102346446(IYD)

CMK:	103179239(iyd)

RTP:	109920078(iyd)

CPLA:

122553024(iyd)

HOC:	132819581(iyd)

LERI:

129699355(iyd)

HAKA:

140730692(iyd)

PMRN:

116953850(IYD)

LRJ:	133356322(IYD)

BFO:

118412564

BBEL:

109465739

SPU:

592720

LPIC:

129265107

APLC:

110984398

ARUN:

117297389

AAMU:

139945994

AFIL:

140153720

AJC:

117114258

SKO:

100378150

PFLL:

139149327

DER:

6544037

DSI:	Dsimw501_GD12829(Dsim_GD12829)

DYA:	Dyak_GE20241

DSR:

110185196

DPO:

4812976

DPE:

6596048

DMN:

108153127

DWI:

6646349

DMO:	Dmoj_GI13193

DAZ:

108612304

DNV:

108650180

DHE:

111604781

MDE:

101888214

LCQ:

111676833

CVJ:	135953211(Iyd)

AGA:

1276132

ACOZ:

120961464

AMAP:

126562669

AMRS:

128714116

ACOS:

131266621

AAG:

5572342

AALB:

109420216

ASUA:

134214501

CQU:	CpipJ_CPIJ012177 CpipJ_CPIJ012183

CPII:

120420569 120420573

CBRI:

134831088

LLL:

129796208

PPAP:

129803382

AME:

413740

ACER:

107995304

ALAB:

122718561

ADR:

102671569

AFLR:

100867717

BIM:

100748968

BBIF:

117210494

BVK:

117234967

BVAN:

117159150

BHUN:

126874132

BTER:

100647581

BAFF:

126925154

BPYO:

122570397

BPAS:

132914325

FVI:

122532713

CCAL:

108632882

OBB:

114880209

OLG:

117607892

MGEN:

117222132 117222172

NMEA:

116434583

CGIG:

122396287

SOC:

105195062

MPHA:

105832974

AEC:

105146911

ACEP:

105623675

ACOC:

108692763

MZT:	108728705(Iyd)

CCOA:

108778108

PBAR:

105429559

VEM:

105567035

COBS:

139108333(Iyd)

TLN:	139808963(Iyd)

HST:

105189951

DQU:

106750633

CFO:

105256572

FEX:

115235866

PMEC:

138938807(Iyd)

LHU:	105676104(Iyd)

PGC:

109857517

OBO:

105282046

PCF:

106789438

PFUC:

122522641

VPS:

122638033

VCRB:

124427154

VVE:

124946892

NVI:

100122307

CSOL:

105359306

TPRE:

106659929

LHT:

122508555

LBD:

127284506

MDL:

103576191

CGLO:

123260224

CTYP:

141531941(Iyd)

FAS:

105263700

DAM:

107047974

AGIF:

122858301

CINS:

118072676

VCAN:

122413798

CCIN:

107269878

DSM:

124414686

NPT:	124223523(Iyd)

NFB:

124186745

NLO:

107217432

NVG:

124309259

AROA:

105688832

TCA:

654861

TMOL:

138141606(Iyd)

DPA:

109538430

ESIM:

136414376(Iyd)

EFOR:

136346111(Iyd)

SOY:

115884356

AGRG:

126747334

ATD:

109596450

CSET:

123309415

HAXR:

123684616

AGB:

108908234

LDC:

111501842

DVV:

114337596

NVL:

108559097

APLN:

108735739

PPYR:

116181484

OTU:

111425738

BMOR:

101741567

BMAN:

114246719

MSEX:

115447913

DPL:	KGM_204451

BANY:

112050789

MJU:

123868905

NIQ:

126773032

VCD:

124535372

MCIX:

123657678

PMAC:

106711132

PPOT:

106102632

PXU:

106117188

BPHI:

137923672(Iyd)

PRAP:

110992079

PBX:

123708931

PNAP:

125049401

ZCE:

119838757

CCRC:

123694849

LSIN:

126974564

AAGE:

121725322

HAW:	110382329(iyd)

HZE:

124634640

TNL:

113493372

SLIU:

111355989

OFU:

114363914

ONU:

135077055

ATRA:

106134803

GMW:

113518851

PXY:

105389069

PGW:

126369995

LGLY:

125236957

CSTB:

134749866

CFUM:

141434266

CFEL:

113386772

CCRN:

123292656

BTAB:

109040035

DCI:

103524276

CLEC:

106666802

HHAL:

106683696(Iyd)

NLU:

111064574

HVI:	124365063 124365288

MQU:

128999891

PHU:	Phum_PHUM509030

FOC:

113210284

TPAL:

117641826

ZNE:

110839726

CSEC:

111861339

PAME:

138710543(Iyd)

SGRE:

126334817

BROR:

134527359

IEL:

124167007

HAMR:

139695156(Iyd)

FCD:

110843860

DPX:	DAPPUDRAFT_205384

DMK:

116918943

DPZ:

124343307

PVM:	113811066(Iyd)

PJA:

122244807

PCHN:

125046098

PMOO:

119590704

HAME:

121868369

PCLA:

123758531(Iyd) 123764400

CQD:	128687762 128687927

PTRU:

123499636

ESN:

127004584

MNZ:	135202280 135226286

MRJ:	136847225(Iyd)

PORN:

139754804(Iyd)

HAZT:

108674310

EAF:

111699145

TCF:	131877945 131877946

PPOI:

119112641

CEL:	CELE_C02C2.5(sup-18)

CBR:

CBG_12270

CRQ:	GCK72_009090

NAI:	NECAME_15149

BMY:	BM_BM1907(Bma-sup-18)

LOA:	LOAG_00270

OBI:

106878694

OSN:

115223784

LJP:

135481038

LAK:	106162026 106162027

NVE:	5512829 5512833

EPA:

110231843

ATEN:

116302595

AMIL:

114954678 122957107

MCAZ:

138052773 138052774

MFOO:

137996846 137996848

SPIS:

111323578

DGT:

114524558

HMG:

100199794

HSY:

130645328

AQU:

105316407

SRE:	PTSG_08135

XBC:	ELE36_19565

DTX:	ATSB10_04660

XBA:	C7S18_02865

TAMN:

N4264_01745

VHA:	VIBHAR_00135

VCA:	M892_11935

VHR:	AL538_08285

VOW:	A9237_09450

VRO:	BSZ04_09115

VNI:	VIBNI_A3241

VCY:	IX92_15070

VCT:	JV59_38335

VAQ:	FIV01_01020

VNP:	KW548_00945

PAGR:

E2H98_15025

SDN:

Sden_0863

SFR:

Sfri_3203

SAZ:

Sama_2969

SPL:

Spea_0762

SHL:

Shal_0814

SWD:

Swoo_0947

SWP:

swp_4286

SJA:	SJ2017_3451

SPSW:

Sps_04908

SLJ:	EGC82_04950

SMAI:

EXU30_13600

SPOL:

FH971_03295

SKH:	STH12_02868

SLIT:

JQC75_15255

SPSH:

FM037_23360

SEUR:

FM038_004210

SGLA:

FJ709_15795

SINV:

K8B83_19965

SZH:	K0H63_16265

SPSR:

EGC80_00950

SHEA:

GUY17_03565

SHEH:

ABIS04_03240

SHEM:

HWQ47_21685

CPS:

CPS_3676

COZ:	A3Q34_04480

COLW:

A3Q33_02310

COLA:

DBO93_05250

COV:	EKO29_13720

CBER:

B5D82_03870

LSD:	EMK97_17920

THT:	E2K93_11810

THAP:

FNC98_03020

THAB:

LP316_15665

PSM:

PSM_A2896

PSEO:

OM33_03620

PIA:	PI2015_2837

PPHE:

PP2015_3188

PBW:	D172_016315

PRR:	AT705_11100

PLZ:	S4054249_00855

PALN:

B0W48_06965

PPIS:

B1L02_17410

PEA:	PESP_a3619

PSPO:

PSPO_a0084

PART:

PARC_a3728

PTU:	PTUN_a0262

PTD:	PTET_a3279

PSEN:

PNC201_16840

PDJ:	D0907_01525

PAGA:

PAGA_a3651

PCAR:

PC2016_0211

PMAA:

CPA52_15045

PXI:	J5O05_11820

PVB:	J5X90_04425

PSAZ:

PA25_01550

PDV:	FFU37_14375

PFLI:

CTT31_17135

PMAZ:

R5H13_17950

PSHO:

KQ246_15440

PSMM:

PspMM1_30120

PXSI:

EJ103_15425

PSJS:

GZH31_01270

PSKA:

KAN5_30910

PSRR:

ELR70_23645

PSMB:

H3302_01265

PSLC:

JG479_15300

PSPS:

PS1M3_01980

PSYM:

J1N51_03125

AMC:	MADE_1014195

AMAA:

amad1_14535

AMAL:

I607_13765

AMAE:

I876_14150

AMAO:

I634_13995

AMAD:

I636_14135

AMAI:

I635_14510

AMAG:

I533_13755

AMAC:

MASE_13720

AMB:	AMBAS45_14220

AMG:	AMEC673_14045

AMK:	AMBLS11_13620

ALT:	ambt_02675

AAL:	EP13_13810

AAUS:

EP12_14500

ASP:

AOR13_524

ASQ:	AVL57_15905

AAW:	AVL56_14835

ALE:	AV939_14810

ALZ:	AV940_14560

ALTE:

ALT761_03080

ALTM:

BM527_13675

ALTR:

BM528_06835

AMAB:

ACI7YQ_13970

ALTB:

IUA53_05335

GNI:

GNIT_3191

GPS:

C427_0200

SAGA:

M5M_17210

SLIO:

R50072_28400

MICC:

AUP74_01253

MAGA:

Mag101_01735

MICT:

FIU95_01740

MHYD:

GTQ55_01940

MICZ:

GL2_09850

MVB:	MJO52_01905

MICY:

HUW35_05055

MSPN:

M8T91_01345

HJA:	BST95_13400

HALC:

EY643_09055

PAQM:

E0F26_03825

CVB:	R0135_00215

CBRV:

R0137_13960

RHEI:

ATY27_05200 ATY27_11750

WOC:	BA177_17820

LLP:	GH975_06675

PLEI:

Q9312_02580

KGE:

TQ33_1208

CVC:	BKX93_02275

CHRO:

CXB49_10295

CHRI:

DK842_19025

CHRB:

DK843_01955

CHRM:

FYK34_07020

PHS:	C2L64_47720

UND:	UNDKW_5453

UNY:	UNDYM_5433

UCY:	RF679_08785

MESP:

C1M53_13665

MESR:

FGU64_13685

MESS:

ABSY17_05150

MEAA:

ACG873_24335

NIY:	FQ775_06135

NKI:	KW403_05530

NRH:	T8J41_08535

MESO:

BSQ44_05260

AAK:	AA2016_1428

AMIH:

CO731_01389

AMIS:

Amn_49150

ANJ:

AMD1_1426

RPOD:

E0E05_01510

OST:	ABWH87_00130

AMAX:

ABWH92_03680

EAH:	FA04_03475

ECAA:

J3R84_03355

ENP:	JVX98_17165

HOE:	IMCC20628_04201

BVES:

QO058_17235

BOI:	BLM15_20185

MTEZ:

HPT29_003205

MMYR:

MXMO3_01399

PSIN:

CAK95_06775

PSF:

PSE_4610

LAP:	ACP90_26965

LABR:

CHH27_20700

LABP:

FJ695_02765

LABT:

FIU93_04735

LAGG:

B0E33_11030

RPOP:

K1718_01050

PHR:	C6569_04595

PSTG:

E8M01_19955

CHQ:	AQ619_01645

APAH:

KB221_04270

SIL:

SPO1077

RUA:	D1823_01295

RUT:	FIU92_11815

RCON:

K3740_13515

RUY:	NOR97_11125

JAN:

Jann_1728

PHAE:

N1037_15100

OAT:	OAN307_c04840

OAR:	OA238_c01150

OTM:	OSB_01100(nox)

OCT:	FTO60_00550

LMD:	METH_06025

LEJ:	ETW24_07220

LEV:	ETW23_12525

LEIM:

K3557_05355

SULI:

C1J05_04920

SMED:

JNX03_16935

TOM:	BWR18_16340

RID:	RIdsm_04696(nox_1)

ROM:	EI983_16730

RPHC:

RZ517_01600

RRL:	RZS32_007075

SAGU:

CDO87_04725

SSTL:

ABFK29_17595

OCD:	FHY55_07325

ROT:	FIV09_01195(nox)

MALU:

KU6B_06870

TMD:	KUV46_07095

PALX:

GQA70_15935

LALG:

LentiSH36_02469

MARU:

FIU81_05845(fbiB)

ASCA:

QEZ52_17460

FYT:	QF092_10735

PZH:	CX676_15290

PARO:

CUV01_08285

PSAP:

JHX88_07415

PFIS:

JHX87_11665

PSTL:

JHW45_02495

PALS:

PAF20_07085

PDIM:

PAF18_10140

GEH:	HYN69_01575

TAW:	EI545_08820

SEDI:

EBB79_17450

PAMO:

BAR1_14245

THAS:

C6Y53_01555

AALK:

LGT41_0014305

AMYL:

QBD29_00695

SINR:

O5O51_14250

MMR:	Mmar10_1593

GABY:

AB6B38_03095

HYT:	HXX25_05375

FRB:	AB6B37_07725

APOP:

AB6B39_10605

NOT:	C7W88_16490

SAL:

Sala_2200

SPHX:

E5675_17155

SPEG:

SPYCW_0514

SPFD:

SPYCA_0144

SPUS:

KEC45_02010 KEC45_17945

SPYF:

EAO27_19485

SPHI:

TS85_14675

SPLM:

BXU08_18825

SPHC:

CVN68_20905

SXA:	FMM02_03845

SPNB:

O3305_22180

SPRR:

OIM94_17285

SPCA:

GL174_01725

CIJ:	WG74_10175

SPHG:

AZE99_02385

SFLA:

SPHFLASMR4Y_01902

SPHY:

CHN51_03180

SPHL:

LPB140_00745

SLAA:

EUU25_08965

BMAA:

T8S45_03345

SPZR:

G5C33_16515

PALG:

HFP57_15380

PARP:

HFP51_14510

PARJ:

J4G78_16120

PHAO:

HF685_08580

ACOA:

RB602_04415

SMAT:

WJT74_08550

SMIC:

SmB9_00650 SmB9_00730

SAND:

H3309_04710

AEP:	AMC99_01051

ALH:	G6N82_01770

ARUE:

QQX03_08335

ALTC:

P7228_13240

AMX:	AM2010_808

PMAS:

NCF86_04980

ANH:	A6F65_01600(nox)

ADO:	A6F68_02102(nfrA2)

ERY:	CP97_10515

EGN:	BMF35_a1805

EFV:	CHH26_08875

QSO:	IRL76_04950

QAR:	K3148_13695

QGE:	K3136_00115

QPS:	K3166_04860

QXI:	K3162_00105

QPR:	SD421_11425

ELI:

ELI_05535

ELQ:	Ga0102493_112646

ERK:	CD351_09430

ERR:	DVR09_09250

ERF:	FIU90_09530(yodC)

EMV:	HQR01_08925

ERYT:

KDC96_05500

ERYS:

LY632_09240

PHZ:	CHX26_10485

POT:	E2E27_12470

PORC:

CBR61_10025

AFLV:

QQW98_12220

EBK:	PF049_08520

TXI:

TH3_16610

THAC:

CSC3H3_15580

TII:	DY252_05255

THAI:

IT893_15530

TLU:	R1T41_04110

TTB:	MACH01_30530

THGO:

M9H61_17840

THAD:

IT971_17645

HFL:	PUV54_04995

HFO:	ABFZ83_11030

ECOG:

FIV45_14720

PAQI:

KW060_00555

APB:	SAR116_2158

KOZ:	KFF44_15835

TMK:	QGN29_01570

GSO:	PH603_03485

AGE:	AA314_00515

PBRU:

LZC95_49575

PRUE:

LVJ94_48355

HOH:

Hoch_2634

SLOM:

PXH66_15430

SOA:	G3M56_004275

MFF:	MFFC18_12270(nox)

ULI:	ETAA1_29900(nox)

UHL:	UABHE_003058

OCK:	EXM22_15365

PFER:

IRI77_35330

GPH:	GEMMAAP_01480

GMT:	V3331_00070

CHF:	KTO58_00400

CHIM:

CK934_28850

HHY:	Halhy_2296

SGN:

SGRA_2150

AUP:	AsAng_0046430

ALM:	AO498_03605

ALGO:

GYM62_16350

AHAO:

OM944_13925

AHAP:

V8V91_17595

ALS:	DJ013_16660

MAQA:

LAG90_19510

MTT:	Ftrac_3213

MHAA:

Q3Y49_10715

MARP:

QYS47_34085

MSAA:

QYS49_39310

FPF:	DCC35_08660

FLM:

MY04_3755

FLL:	EI427_14050

FYA:	KMW28_17780

FKA:	KM029_15360

FUV:	JR347_11215

FMM:	LVD15_25750

FUA:	LVD17_18815

REK:	N6H18_11530

RCG:	N7E81_13010

TPEL:

P0M28_11435

RSR:	T7867_13735

PPSV:

PEPS_32550

ATK:	AUTU_44350

GFO:

GFO_0968

GRL:	LPB144_05000

GFL:

GRFL_2853

GRS:	C7S20_12820

FFA:	FFWV33_09025

FBC:	FB2170_13031

ZGA:	ZOBELLIA_4305(iyd)

ZLA:	Q5W13_20490

LUT:	Lupro_04790

AQR:	HN014_00670

LUY:	QZH61_11355

FBQ:	D1817_07360

FLU:	CHH17_14395

OHO:	Oweho_2551

CHYD:

H4K34_08730

CTS:

Ctha_1982

RBAR:

AWN76_006855

CPRV:

CYPRO_1829

BCO:	Bcell_3839

ETM:	CE91St48_29550

EMJ:	V1225_12405

GFE:	Gferi_17575

HALS:

D7D81_09845

GBX:	SANA_01990

MANR:

MPAN_001260

EUZ:	DVS28_a4930

NBR:	O3I_040975

NTP:	CRH09_18310

NOZ:	DMB37_19950

NAH:	F5544_13005

NIE:	KV110_40220

NVU:	V7968_06205

SCO:	SCO5324(SC6G9.09c)

SGR:

SGR_1987

SFI:

SFUL_5377

SANL:

KZO11_27060

SCYE:

R2B67_08780

SLV:	SLIV_11750

STRE:

GZL_06707

SLC:	SL103_10160

STRM:

M444_24320

SRN:	A4G23_00156(nox)

STRT:

A8713_31000

SCLF:

BB341_00635

SALW:

CP975_25370

SNR:	SNOUR_31230

SALU:

DC74_2304

SALL:

SAZ_12880

STRD:

NI25_12565

SSIA:

A7J05_11230

SVU:	B1H20_26090

SGV:	B1H19_11115

SLAU:

SLA_6171

SALF:

SMD44_06136

SALJ:

SMD11_5193

SLX:	SLAV_12140(fbiB1)

STRO:

STRMOE7_09950

SFK:

KY5_5684c

SQZ:	FQU76_33100

SKA:	CP970_12670

SGZ:	C0216_06375

SVN:	CP980_09870

SRK:	FGW37_07620

SBY:	H7H31_28250

SRIM:

CP984_31945

SSUB:

CP968_10140

STSU:

B7R87_00600

SSPB:

CP982_29455

SNF:	JYK04_05917(fbiB_2)

SHUN:

DWB77_02378(fbiB_1)

SCAL:

I6J39_25785

SMOB:

J7W19_06910

SHK:	J2N69_26325

SINE:

KI385_11625

SAOV:

G3H79_10170

SDUR:

M4V62_13875

SYAN:

NRK68_24230

SNIG:

HEK616_16790

SXT:	KPP03845_105259(fbiB_2)

SENG:

OJ254_19005

SGK:	PET44_23090

SYUN:

MOV08_31235

SOV:	QZH56_28070

SHAU:

K9S39_33905

SFP:	QUY26_10845

STTN:

BSL84_23685

STRZ:

OYE22_27535

STII:

DRB96_04795

STIC:

DRB89_05470

SPAZ:

ABXI76_09600

STBR:

ABDE16_11740

STVB:

OH133_10450

STYI:

C9F11_28630(fbiB3)

SSIR:

WAB15_10370

KAB:	B7C62_26805

KAU:	B6264_20470

NDK:	I601_1221(nox)

KQI:	F1D05_32125

KRI:	OX958_24415

NGV:	CDO52_22475

SRO:

Sros_1916

NOA:	BKM31_35160

NGN:	LCN96_10265

SEN:

SACE_3932

AMD:

AMED_4353

AMN:

RAM_22170

AMM:

AMES_4301

AMZ:

B737_4301

AOI:

AORI_3440

AJA:	AJAP_21995

AMYC:

CU254_20195

AMYB:

BKN51_15310

AAB:	A4R43_40350

AMYY:

YIM_37335(fbiB1)

AORI:

SD37_17815

APRT:

MUY14_15595

AROO:

NQK81_05265

ARHD:

VSH64_25530

AMOG:

QRX60_35930

ACOR:

LCL61_27470

AMYZ:

HUW46_06346(fbiB_2)

ACAB:

QRX50_19120

ANW:	QP939_42000

AMYD:

K1T34_06135

AMYE:

MJQ72_11120

AMYS:

CVV72_12390

SESP:

BN6_24810

SSYI:

EKG83_11195

KAL:

KALB_1623

KUT:	JJ691_13020

KBR:	Q4V65_45495

KPHY:

AOZ06_11730

LED:	BBK82_28715

ALO:

CRK55490

ACTU:

Actkin_01389(fbiB_1)

AAUR:

V5P93_001446

CROS:

N8J89_07210

UME:	RM788_13515

STP:	Strop_2104

SAQ:

Sare_2247

MICH:

FJK98_19055

MCAB:

HXZ27_19210

VMA:	VAB18032_24510

PLAB:

C6361_01410

PLAT:

C6W10_20240

PFLA:

Pflav_028250

PSUU:

Psuf_077950

ATL:	Athai_02490

CAI:

Caci_2239

SNA:

Snas_4783

AYM:	YM304_23620

KBS:	EPA93_11175

PMET:

G4Y79_10860

DPD:	Deipe_0653

DEIN:

DAAJ005_01325

OPR:	Ocepr_1958

FVA:	FV113G1_15940

FUL:	C4N20_14230

» show all

Reference

1 [PMID:4394169]

Authors

Rosenberg IN

Title

Purification of iodotyrosine deiodinase from bovine thyroid.

Journal

Metabolism 19:785-98 (1970)
DOI:10.1016/0026-0495(70)90076-4

Reference

2 [PMID:15289438]

Authors

Gnidehou S, Caillou B, Talbot M, Ohayon R, Kaniewski J, Noel-Hudson MS, Morand S, Agnangji D, Sezan A, Courtin F, Virion A, Dupuy C

Title

Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site.

Journal

FASEB J 18:1574-6 (2004)
DOI:10.1096/fj.04-2023fje

Sequence

[hsa:389434] [ssc:403124]

Reference

3 [PMID:16316988]

Authors

Friedman JE, Watson JA Jr, Lam DW, Rokita SE

Title

Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamily.

Journal

J Biol Chem 281:2812-9 (2006)
DOI:10.1074/jbc.M510365200

Reference

4 [PMID:19436071]

Authors

Thomas SR, McTamney PM, Adler JM, Laronde-Leblanc N, Rokita SE

Title

Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands.

Journal

J Biol Chem 284:19659-67 (2009)
DOI:10.1074/jbc.M109.013458

Sequence

[mmu:70337]

Other DBs

ExplorEnz - The Enzyme Database:

1.21.1.1

IUBMB Enzyme Nomenclature:

1.21.1.1

ExPASy - ENZYME nomenclature database:

1.21.1.1

BRENDA, the Enzyme Database:

1.21.1.1

LinkDB

DBGET integrated database retrieval system