Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y
BRITE hierarchy

L-tyrosine,iodide:NADP+ oxidoreductase (iodinating)

L-tyrosine + 2 NADP+ + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ (overall reaction) [RN:R10059];
(1a) L-tyrosine + NADP+ + iodide = 3-iodo-L-tyrosine + NADPH + H+ [RN:R09521];
(1b) 3-iodo-L-tyrosine + NADP+ + iodide = 3,5-diiodo-L-tyrosine + NADPH + H+ [RN:R09522]

R09521 R09522 R10059
Reaction

L-tyrosine [CPD:C00082];
NADP+ [CPD:C00006];
iodide [CPD:C00708];
3-iodo-L-tyrosine [CPD:C02515]

The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein. Requires FMN.

EC 1.21.1.1 created 2010 as EC 1.22.1.1 transfered 2015 to EC 1.21.1.1

1  [PMID:4394169]

Rosenberg IN

Purification of iodotyrosine deiodinase from bovine thyroid.

Metabolism 19:785-98 (1970)
DOI:10.1016/0026-0495(70)90076-4

2  [PMID:15289438]

Gnidehou S, Caillou B, Talbot M, Ohayon R, Kaniewski J, Noel-Hudson MS, Morand S, Agnangji D, Sezan A, Courtin F, Virion A, Dupuy C

Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site.

FASEB J 18:1574-6 (2004)
DOI:10.1096/fj.04-2023fje

[hsa:389434] [ssc:403124]

3  [PMID:16316988]

Friedman JE, Watson JA Jr, Lam DW, Rokita SE

Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin  reductase superfamily.

J Biol Chem 281:2812-9 (2006)
DOI:10.1074/jbc.M510365200

4  [PMID:19436071]

Thomas SR, McTamney PM, Adler JM, Laronde-Leblanc N, Rokita SE

Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands.

J Biol Chem 284:19659-67 (2009)
DOI:10.1074/jbc.M109.013458

[mmu:70337]