| Entry |
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| Name |
trimethylamine-N-oxide reductase;
TMAO reductase;
TOR;
torA (gene name);
torZ (gene name);
bisZ (gene name);
trimethylamine-N-oxide reductase (cytochrome c)
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| Class |
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor
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| Sysname |
trimethylamine:cytochrome c oxidoreductase
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| Reaction(IUBMB) |
trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+ [RN: R02560]
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| Reaction(KEGG) |
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| Substrate |
trimethylamine [CPD: C00565];
(ferricytochrome c)-subunit;
H2O [CPD: C00001]
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| Product |
trimethylamine N-oxide [CPD: C01104];
(ferrocytochrome c)-subunit;
H+ [CPD: C00080]
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| Comment |
Contains bis(molybdopterin guanine dinucleotide)molybdenum cofactor. The reductant is a membrane-bound multiheme cytochrome c. Also reduces dimethyl sulfoxide to dimethyl sulfide.
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| History |
EC 1.7.2.3 created 2002, modified 2018
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K07811 | trimethylamine-N-oxide reductase (cytochrome c) |
| K07812 | trimethylamine-N-oxide reductase (cytochrome c) |
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| Genes |
» show all
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| Reference |
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| Authors |
Arata H, Shimizu M, Takamiya K. |
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| Title |
Purification and properties of trimethylamine N-oxide reductase from aerobic photosynthetic bacterium Roseobacter denitrificans. |
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| Journal |
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| Reference |
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| Authors |
Knablein J, Dobbek H, Ehlert S, Schneider F. |
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| Title |
Isolation, cloning, sequence analysis and X-ray structure of dimethyl sulfoxide/trimethylamine N-oxide reductase from Rhodobacter capsulatus. |
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| Journal |
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| Reference |
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| Authors |
Czjzek M, Dos Santos JP, Pommier J, Giordano G, Mejean V, Haser R. |
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| Title |
Crystal structure of oxidized trimethylamine N-oxide reductase from Shewanella massilia at 2.5 A resolution. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Gon S, Giudici-Orticoni MT, Mejean V, Iobbi-Nivol C. |
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| Title |
Electron transfer and binding of the c-type cytochrome TorC to the trimethylamine N-oxide reductase in Escherichia coli. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Zhang L, Nelson KJ, Rajagopalan KV, George GN |
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| Title |
Structure of the molybdenum site of Escherichia coli trimethylamine N-oxide reductase. |
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| Journal |
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| Reference |
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| Authors |
Yin QJ, Zhang WJ, Qi XQ, Zhang SD, Jiang T, Li XG, Chen Y, Santini CL, Zhou H, Chou IM, Wu LF |
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| Title |
High Hydrostatic Pressure Inducible Trimethylamine N-Oxide Reductase Improves the Pressure Tolerance of Piezosensitive Bacteria Vibrio fluvialis. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.7.2.3 |
| ExPASy - ENZYME nomenclature database: | 1.7.2.3 |
| BRENDA, the Enzyme Database: | 1.7.2.3 |
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| LinkDB |
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