Entry |
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Name |
sarcosine/dimethylglycine N-methyltransferase;
ApDMT;
sarcosine-dimethylglycine methyltransferase;
SDMT;
sarcosine dimethylglycine N-methyltransferase;
S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase
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Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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Sysname |
S-adenosyl-L-methionine:sarcosine(or N,N-dimethylglycine) N-methyltransferase [N,N-dimethylglycine(or betaine)-forming]
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Reaction(IUBMB) |
2 S-adenosyl-L-methionine + sarcosine = 2 S-adenosyl-L-homocysteine + betaine (overall reaction) [RN: R10061];
(1a) S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine [RN: R07243];
(1b) S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine [RN: R07244]
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Reaction(KEGG) |
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Substrate |
S-adenosyl-L-methionine [CPD: C00019];
sarcosine [CPD: C00213];
N,N-dimethylglycine [CPD: C01026]
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Product |
S-adenosyl-L-homocysteine [CPD: C00021];
betaine [CPD: C00719];
N,N-dimethylglycine [CPD: C01026]
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Comment |
Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process. The first enzyme, EC 2.1.1.156, glycine/sarcosine N-methyltransferase, leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of this enzyme. Both of these enzymes can catalyse the formation of N,N-dimethylglycine from sarcosine [3]. The reactions are strongly inhibited by S-adenosyl-L-homocysteine.
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History |
EC 2.1.1.157 created 2005, modified 2010
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Pathway |
ec00260 | Glycine, serine and threonine metabolism |
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Orthology |
K18897 | sarcosine/dimethylglycine N-methyltransferase |
K24071 | glycine/sarcosine/dimethylglycine N-methyltransferase |
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Genes |
» show all
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Reference |
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Authors |
Nyyssola A, Kerovuo J, Kaukinen P, von Weymarn N, Reinikainen T |
Title |
Extreme halophiles synthesize betaine from glycine by methylation. |
Journal |
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Sequence |
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Reference |
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Authors |
Nyyssola A, Reinikainen T, Leisola M |
Title |
Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase. |
Journal |
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Sequence |
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Reference |
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Authors |
Waditee R, Tanaka Y, Aoki K, Hibino T, Jikuya H, Takano J, Takabe T, Takabe T |
Title |
Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.1.1.157 |
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LinkDB |
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