Entry |
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Name |
lipoyl amidotransferase;
LipL (gene name, ambiguous)
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Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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Sysname |
[glycine cleavage system H]-N6-lipoyl-L-lysine:[lipoyl-carrier protein]-N6-L-lysine lipoyltransferase
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Reaction(IUBMB) |
[glycine cleavage system H]-N6-lipoyl-L-lysine + a [lipoyl-carrier protein] = glycine cleavage system H + a [lipoyl-carrier protein]-N6-lipoyl-L-lysine [RN: R12426]
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Reaction(KEGG) |
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Substrate |
[glycine cleavage system H]-N6-lipoyl-L-lysine [CPD: C02051];
[lipoyl-carrier protein]
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Product |
glycine cleavage system H [CPD: C22157];
[lipoyl-carrier protein]-N6-lipoyl-L-lysine
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Comment |
In the bacterium Listeria monocytogenes the enzyme takes part in a pathway for scavenging of lipoic acid. The enzyme is bound to 2-oxo-acid dehydrogenases such as the pyruvate dehydrogenase complex, where it transfers the lipoyl moiety from lipoyl-[glycine cleavage system H] to the E2 subunits of the complexes.
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History |
EC 2.3.1.200 created 2012
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Pathway |
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Orthology |
K18821 | lipoyl amidotransferase |
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Genes |
» show all
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Reference |
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Authors |
Christensen QH, Hagar JA, O'Riordan MX, Cronan JE |
Title |
A complex lipoate utilization pathway in Listeria monocytogenes. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.3.1.200 |
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LinkDB |
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