Entry |
|
Name |
octanoyl-[GcvH]:protein N-octanoyltransferase;
LipL;
octanoyl-[GcvH]:E2 amidotransferase;
ywfL (gene name)
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Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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Sysname |
[glycine cleavage system H]-N6-octanoyl-L-lysine:[lipoyl-carrier protein]-N6-L-lysine octanoyltransferase
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Reaction(IUBMB) |
[glycine cleavage system H]-N6-octanoyl-L-lysine + a [lipoyl-carrier protein] = glycine cleavage system H + a [lipoyl-carrier protein]-N6-octanoyl-L-lysine [RN: R12425]
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Reaction(KEGG) |
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Substrate |
[glycine cleavage system H]-N6-octanoyl-L-lysine [CPD: C22159];
[lipoyl-carrier protein]
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Product |
glycine cleavage system H [CPD: C22157];
[lipoyl-carrier protein]-N6-octanoyl-L-lysine
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Comment |
In the bacterium Bacillus subtilis it has been shown that the enzyme catalyses the
amidotransfer of the octanoyl moiety from [glycine cleavage system H]-N6-octanoyl-L-lysine (i.e. octanoyl-GcvH) to the E2 subunit (dihydrolipoamide acetyltransferase) of pyruvate dehydrogenase.
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History |
EC 2.3.1.204 created 2012
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Pathway |
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Orthology |
K16869 | octanoyl-[GcvH]:protein N-octanoyltransferase |
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Genes |
» show all
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Reference |
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Authors |
Christensen QH, Martin N, Mansilla MC, de Mendoza D, Cronan JE |
Title |
A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis. |
Journal |
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Sequence |
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Reference |
|
Authors |
Martin N, Christensen QH, Mansilla MC, Cronan JE, de Mendoza D |
Title |
A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.3.1.204 |
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LinkDB |
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