| Entry |
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| Name |
choline O-acetyltransferase;
choline acetylase;
choline acetyltransferase
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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| Sysname |
acetyl-CoA:choline O-acetyltransferase
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| Reaction(IUBMB) |
acetyl-CoA + choline = CoA + O-acetylcholine [RN: R01023]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Propanoyl-CoA can act, more slowly, in place of acetyl-CoA.
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| History |
EC 2.3.1.6 created 1961
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| Pathway |
| ec00564 | Glycerophospholipid metabolism |
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| Orthology |
| K00623 | choline O-acetyltransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
BERMAN R, WILSON IB, NACHMANSOHN D. |
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| Title |
Choline acetylase specificity in relation to biological function. |
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| Journal |
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| Reference |
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| Authors |
BERRY JF, WHITTAKER VP. |
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| Title |
The acyl-group specificity of choline acetylase. |
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| Journal |
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| Reference |
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| Authors |
FRITZ IB, SCHULTZ SK. |
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| Title |
CARNITINE ACETYLTRANSFERASE. II. INHIBIITON BY CARNITINE ANALOGUES AND BY SULFHYDRYL REAGENTS. |
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| Journal |
J Biol Chem 240:2188-92 (1965) |
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| Reference |
4 |
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| Authors |
Schuberth, J. |
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| Title |
Choline acetyltransferase. Purification and effect of salts on the mechanism of the enzyme-catalysed reaction. |
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| Journal |
Biochim Biophys Acta 122:470-481 (1966) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.3.1.6 |
| ExPASy - ENZYME nomenclature database: | 2.3.1.6 |
| BRENDA, the Enzyme Database: | 2.3.1.6 |
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| LinkDB |
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