KEGG ENZYME: 2.3.2.10

ENZYME: 2.3.2.10

Entry

EC 2.3.2.10                 Enzyme

Name

UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase;
alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase;
UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase;
uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase;
L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase;
L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase

Class

Transferases;
Acyltransferases;
Aminoacyltransferases

Sysname

L-alanyl-tRNAAla:UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase

Reaction(IUBMB)

L-alanyl-tRNAAla + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine = tRNAAla + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine [RN:R04613]

Reaction(KEGG)

R04613;
(other) R08779

Substrate

L-alanyl-tRNA(Ala) [CPD:C00886];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine

Product

tRNA(Ala) [CPD:C01635];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine

Comment

Also acts on L-seryl-tRNASer.

History

EC 2.3.2.10 created 1972, modified 2013

Pathway

ec00550

Peptidoglycan biosynthesis

Orthology

K05363

serine/alanine adding enzyme

Genes

AMH:	I633_14530

AMAA:

amad1_14030

AMAD:

I636_13635

AMAI:

I635_14005

BACO:

OXB_0272

GMO:	NCTC11323_00057(femB_1)

GSA:	FOC50_04790

GHA:	NCTC10459_01694(femX)

PLN:	Plano_2272 Plano_2278

PKU:	AUO94_04290 AUO94_04295 AUO94_04375

PRT:	AUC31_15470 AUC31_15485 AUC31_15490 AUC31_15495

PLL:	I858_011440 I858_011445 I858_011520

PANA:

BBH88_07570 BBH88_07575

PDG:	BCM40_03825 BCM40_03870 BCM40_03895

PHC:	BBI08_08615 BBI08_08640 BBI08_08685

PPLA:

BBI15_07090 BBI15_07095 BBI15_07100 BBI15_07115

PFAE:

AJGP001_13170 AJGP001_13250

PLX:	CW734_13135 CW734_13140 CW734_13145 CW734_13160

PMAT:

BBI11_12575

PDEC:

H1Q58_11865

PGQ:	FK545_02085 FK545_02090 FK545_02320 FK545_02325

PLAY:

DNR44_008505

SPOR:

SporoP33_05385

SPOP:

SporoP37_05875

SURE:

SporoP32a_05895

SPOS:

DV702_09585

LLK:	LLKF_2319(murM)

LLX:	NCDO2118_2181(murM)

LLM:	llmg_2352(murM)

LLC:

LACR_2372

LLR:

llh_12055

LLN:	LLNZ_12160

LLI:	uc509_2051(murM)

LLW:	kw2_2131(murM)

LGR:

LCGT_0589

LGV:

LCGL_0608

LPET:

lgb_00592(femX)

LFO:	LMK00_02910

LPK:	LACPI_0939

LRN:	CMV25_01205

LCAR:

BHS00_06325

LPAA:

BHS01_06840

SPY:	SPy_0616(murM) SPy_1205

SPZ:	M5005_Spy0511(murM) M5005_Spy0920

SPYM:

M1GAS476_0565(murM) M1GAS476_0975

SPYA:

A20_0553c(murM) A20_0956c(murM)

SPM:	spyM18_0683(femB) spyM18_1156

SPG:	SpyM3_0435(murM.1) SpyM3_0846(murM.2)

SPS:	SPs1046 SPs1420

SPH:	MGAS10270_Spy0505(murM) MGAS10270_Spy1034

SPI:	MGAS10750_Spy0530(murM) MGAS10750_Spy1069

SPJ:	MGAS2096_Spy0523(murM) MGAS2096_Spy0979

SPK:	MGAS9429_Spy0501(murM) MGAS9429_Spy1022

SPF:	SpyM50878(murM) SpyM51352(murM)

SPA:	M6_Spy0532 M6_Spy0909

SPB:	M28_Spy0490(murM) M28_Spy0892

STG:	MGAS15252_0537(murM) MGAS15252_0917

STX:	MGAS1882_0534(murM) MGAS1882_0912

SOZ:	Spy49_0518c(murM.1) Spy49_0951c(murM2)

STZ:	SPYALAB49_000543

SPYH:

L897_02755 L897_04550

SPN:	SP_0615(fibA)

SPD:	SPD_0535(murM_fibA)

SPR:	spr0540(murM)

SPW:	SPCG_0575(murM)

SJJ:

SPJ_0566

SNV:	SPNINV200_05420(murM)

SPX:

SPG_0558

SNT:

SPT_0640

SND:

MYY_0664

SPNN:

T308_02900

SNE:	SPN23F05540(murM)

SPV:

SPH_0708

SNC:	HMPREF0837_10904

SNM:	SP70585_0676

SPP:

SPP_0629

SNI:	INV104_05130(murM)

SPNG:

HMPREF1038_00636

SNB:	SP670_0673

SNP:

SPAP_0601

SNX:	SPNOXC05610(murM)

SNU:	SPNA45_01491(murM)

SPNE:

SPN034156_16110(murM)

SPNU:

SPN034183_05640(murM)

SPNM:

SPN994038_05520(murM)

SPNO:

SPN994039_05530(murM)

SAG:	SAG0509(fibA) SAG0510

SAN:	gbs0555 gbs0556

SAK:	SAK_0659 SAK_0660

SGC:	A964_0540(murM) A964_0541(murM)

SAGS:

SaSA20_0494 SaSA20_0495

SAGL:

GBS222_0486

SAGM:

BSA_5970 BSA_5980

SAGI:

MSA_6120 MSA_6130

SAGR:

SAIL_6260 SAIL_6280

SAGP:

V193_02835

SAGC:

DN94_02835

SAGT:

GBSCOH1_0492 GBSCOH1_0493

SAGE:

EN72_02930 EN72_02935

SAGG:

EN73_03005 EN73_03010

SAGN:

W903_0686 W903_0687

SAGJ:

ID870_06720 ID870_06725

SMU:	SMU_717(murM)

SMC:	SmuNN2025_1280(murM)

SMUT:

SMUGS5_03160

SMJ:	SMULJ23_1281(murM)

SMUA:

SMUFR_0625(murM)

STC:	str1155(murM)

STL:	stu1155(murM)

STE:

STER_1112

STN:

STND_1074

STU:	STH8232_1341(murM)

STW:

Y1U_C0774

STHE:

T303_06625

STHS:

AVT04_09070

SSA:	SSA_0862(murM)

SSK:	SSUD12_0367

SSUI:

T15_0381(murM)

SGO:	SGO_1623(murM)

SEZ:	Sez_1015(murM) Sez_1319(murM)

SEQ:	SZO_06490 SZO_09500

SEZO:

SeseC_01341 SeseC_01704

SEQU:

Q426_02530 Q426_04025

SEU:	SEQ_1178 SEQ_1501

SUB:	SUB0607(murM)

SDS:	SDEG_0637(murM) SDEG_0947

SDG:	SDE12394_03425 SDE12394_05320

SDA:	GGS_0612(murM) GGS_0917(murM)

SDC:	SDSE_0678(murM) SDSE_0983

SDQ:	SDSE167_0691(murM) SDSE167_1051

SGA:	GALLO_1508

SGG:	SGGBAA2069_c15300(murM)

SGT:	SGGB_1503(murM)

SMB:	smi_1584(fibA)

SGW:	D7D53_09215

STOY:

STYK_15260(murM)

SOR:	SOR_1963(murM)

STK:	STP_0096 STP_0414(murM)

STB:	SGPB_1404(murM)

SCP:	HMPREF0833_10855

SCF:

Spaf_1436

SSR:	SALIVB_1141(femX)

STF:	Ssal_01216(murM)

STJ:	SALIVA_0993(murM)

STRS:

SSAL8618_04945

SSAH:

HSISS4_00840(murM)

STD:	SPPN_03240

SMN:

SMA_1515

SIF:

Sinf_1329

SIE:	SCIM_0530(murM)

SIB:	SIR_1111(murM)

SIU:	SII_1132(murM)

SANG:

SAIN_0586(murM)

SANC:

SANR_0598(murM)

SANS:

DK43_07235

SCG:	SCI_0623(murM)

SCON:

SCRE_0603(murM)

SCOS:

SCR2_0603(murM)

SOI:	I872_02755

SIK:	K710_0130 K710_1338

SIQ:	DQ08_00640 DQ08_06195

SIO:	DW64_00640 DW64_06190

SIZ:	SI82_00740 SI82_06345

SLU:

KE3_1458

SIG:	N596_04265

SIP:	N597_06110

SPAT:

A0O21_02760

STRA:

ATM98_03930

SSOB:

DK181_03430

SEQI:

A6J79_07615

SKI:	D7D50_06405

SPEI:

EHW89_02750

SRAT:

FY406_06920

SPLR:

C0J00_06920

SVB:	NCTC12167_01073(murM)

SMEN:

SAMEA4412692_0952(murM)

SFER:

NCTC12278_00174(murM) NCTC12278_01321(femX)

SCAI:

NCTC12191_01576(murM) NCTC12191_02000(femX)

SPSU:

NCTC13786_00865(murM_1) NCTC13786_00965(murM_2) NCTC13786_01918(murM_3)

SCHJ:

DDV21_008035

SPOC:

NCTC10925_00256(femX) NCTC10925_00366(murM_1) NCTC10925_01239(murM_2)

SLAT:

J4854_07435

SAUP:

NCTC3168_01369(murM)

SURN:

NCTC13766_01447(murM)

SACO:

SAME_01700(murM)

SVF:	NCTC3166_01379(murM)

SRUM:

GPZ88_01515

SACY:

O6R09_06440

SMIE:

NCTC11169_00546(murM)

SRUN:

LPB404_07195

SPAM:

SP4011_16620(fibA)

SDID:

N1495_00550 N1495_06555

SZG:	J5M87_06430

SDEN:

SM121_05235

SLIN:

SM123_04005

SNID:

AAFQ93_02045 AAFQ93_03695

SSUV:

PXH68_02825

FPEN:

KIW23_03760 KIW23_06815

LSN:

LSA_00260

LROS:

LROSL1_1092

OOE:

OEOE_1444

OEN:	DSM07_03035

OSI:	DLJ48_01415

LME:

LEUM_1773

LMM:

MI1_07685

LMK:

LMES_1540

LCI:

LCK_01455

LKI:

LKI_07255

LEC:	LGMK_04890

LCN:	C270_01475

LGS:	LEGAS_0406

LGE:	C269_01960

LLF:	BCR17_05370

LGC:	A9176_03910

LSU:	A6B45_08485

LPSE:

FGL85_03835

LKN:	FGL74_03335

WKO:

WKK_02350

WCE:

WS08_1006

WTR:	KHQ32_05625

WCT:

WS74_1072

WCI:	WS105_1068

WCB:	AO080_04420 AO080_09985

WJO:	FOL01_1588

WPA:	CO680_00890

WCF:	C6P13_02120

WSO:	WSWS_00295 WSWS_01363(murM)

WHE:	EFA59_07215

WDI:	H9L19_02390

WVR:	IE337_01505

WCO:	G7084_02380

WEI:	EQG49_04135

EFA:

EF2658

EFL:	EF62_2819(murM)

EFI:	OG1RF_12030(fibA)

EFD:	EFD32_2218(murM)

EFS:

EFS1_2129

EFN:	DENG_02594(murM)

EFQ:

DR75_1359

ESS:	ATZ33_07540

ERX:	ATZ35_16095

MPS:

MPTP_1602

MPX:

MPD5_0449

VHY:	G7082_03765

CIU:	G4D55_16050

FSA:	C5Q98_07305

EUU:	ADJ67_01780

PBQ:	C3V37_07730

APR:

Apre_0286

AVG:	I6H45_04225

AOB:	I6H46_07520

EUC:

EC1_13930

FRO:	AALO17_10780

BULL:

JOS54_03215

AMUO:

KWG62_09260

ERB:	A4V01_18985

GOC:	CXX93_07025

AUM:	AURMO_00310

LEU:	Leucomu_05180

LEB:	G7066_09835

LVI:	G7068_03835

ART:

Arth_0771

ARR:	ARUE_c09440

ARM:

ART_3681

ARE:	AL755_04505

AAQ:	AOC05_01375

ARW:	MB46_00885

ARU:	ASPU41_09360

ARQ:	BWQ92_06145

ARN:	CGK93_05130

ARTP:

E5206_18910

APOA:

J0916_01120

AOD:	Q8Z05_11825

ARTU:

E7Y32_02315

ARTZ:

FCN77_04335

ARTC:

KY499_08700

ARI:	UM93_16200

AAU:

AAur_0993

PUE:	FV140_05115

SATK:

SA2016_1068

CCYC:

SCMU_08430

SPUE:

AB5L97_04340

SERJ:

SGUI_1444

ORN:	DV701_14665 DV701_14675

SERW:

FY030_01845

AHE:

Arch_0164

ARCA:

HC352_00785 HC352_02060 HC352_02065 HC352_02070

APHO:

JTE88_00775

TPY:	CQ11_04900

TPYO:

X956_02825

TBW:	NCTC13354_00579(femX)

TBER:

QPC17_01840

BAST:

BAST_1252

GVG:	HMPREF0421_20446

GVH:	HMPREF9231_1109

RRS:	RoseRS_3975

RCA:

Rcas_1415

HAU:

Haur_0083

SBE:	RAAC3_TM7C01G0351

MMA:

MM_2112

MMAZ:

MmTuc01_2165

MEQ:	MSWHS_0743

MSW:	MSSIT_3014

MHOR:

MSHOH_0633 MSHOH_3235

» show all

Reference

1 [PMID:4248527]

Authors

Plapp R, Strominger JL

Title

Biosynthesis of the peptidoglycan of bacterial cell walls. 18. Purification and properties of L-alanyl transfer ribonucleic acid-uridine diphosphate-N-acetylmuramyl-pentapeptide transferase from Lactobacillus viridescens.

Journal

J Biol Chem 245:3675-82 (1970)

Sequence

[ag:AAG21689]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.2.10

IUBMB Enzyme Nomenclature:

2.3.2.10

ExPASy - ENZYME nomenclature database:

2.3.2.10

BRENDA, the Enzyme Database:

2.3.2.10

CAS:	37257-26-4

LinkDB

DBGET integrated database retrieval system