Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy

L-tyrosyl-tRNATyr:L-tyrosyl-tRNATyr tyrosyltransferase (cyclizing)

2 L-tyrosyl-tRNATyr = 2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl) [RN:R10335]

R10335
Reaction

L-tyrosyl-tRNA(Tyr) [CPD:C02839]

The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-tyrosine residue [2]. The protein, from the bacterium Mycobacterium tuberculosis, also forms small amounts of cyclo(L-tyrosyl-L-phenylalanyl) [1].

EC 2.3.2.21 created 2013

1  [PMID:19430487]

Gondry M, Sauguet L, Belin P, Thai R, Amouroux R, Tellier C, Tuphile K, Jacquet M, Braud S, Courcon M, Masson C, Dubois S, Lautru S, Lecoq A, Hashimoto S, Genet R, Pernodet JL

Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.

Nat Chem Biol 5:414-20 (2009)
DOI:10.1038/nchembio.175

[mtu:Rv2275]

2  [PMID:20852636]

Vetting MW, Hegde SS, Blanchard JS

The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase.

Nat Chem Biol 6:797-9 (2010)
DOI:10.1038/nchembio.440

[mtu:Rv2275]