KEGG ENZYME: 2.3.2.21

ENZYME: 2.3.2.21

Entry

EC 2.3.2.21                 Enzyme

Name

cyclo(L-tyrosyl-L-tyrosyl) synthase;
Rv2275 (gene name);
cYY synthase;
cyclodityrosine synthase

Class

Transferases;
Acyltransferases;
Aminoacyltransferases

Sysname

L-tyrosyl-tRNATyr:L-tyrosyl-tRNATyr tyrosyltransferase (cyclizing)

Reaction(IUBMB)

2 L-tyrosyl-tRNATyr = 2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl) [RN:R10335]

Reaction(KEGG)

R10335

Substrate

L-tyrosyl-tRNA(Tyr) [CPD:C02839]

Product

tRNA(Tyr) [CPD:C00787];
cyclo(L-tyrosyl-L-tyrosyl) [CPD:C20516]

Comment

The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-tyrosine residue [2]. The protein, from the bacterium Mycobacterium tuberculosis, also forms small amounts of cyclo(L-tyrosyl-L-phenylalanyl) [1].

History

EC 2.3.2.21 created 2013

Orthology

K17484

cyclo(L-tyrosyl-L-tyrosyl) synthase

Genes

LSF:	I8J32_012060

MTU:

Rv2275

MTV:

RVBD_2275

MTC:

MT2335

MRA:

MRA_2294

MTF:	TBFG_12300

MTB:	TBMG_01707

MTK:	TBSG_01717

MTZ:	TBXG_001690

MTG:	MRGA327_14020

MTI:	MRGA423_14140

MTE:	CCDC5079_2108

MTUR:

CFBS_2408

MTL:	CCDC5180_2080

MTO:	MTCTRI2_2310

MTD:

UDA_2275

MTJ:	J112_12200

MTUC:

J113_15835

MTUE:

J114_12195

MTUT:

HKBT1_2399

MTUU:

HKBT2_2401

MTQ:	HKBS1_2405

MBO:	BQ2027_MB2298

MBB:

BCG_2292

MBT:

JTY_2286

MBM:	BCGMEX_2280

MBK:	K60_023600

MBX:

BCGT_2099

MAF:

MAF_22850

MMIC:

RN08_2522

MCE:	MCAN_22991

MCQ:	BN44_50221

MCV:	BN43_31517

MCX:	BN42_40196

MORY:

MO_002385

MLJ:	MLAC_22960

MOT:	LTS72_08585

NOZ:	DMB37_28470

NAH:	F5544_25080

NIE:	KV110_23810

NGP:	LTT66_12440

SVE:

SVEN_1864

SVT:	SVTN_10705

SLD:	T261_0959 T261_7889

STRC:

AA958_00575

SCX:	AS200_15075

SRW:	TUE45_00818

SLE:	sle_63980(sle_63980)

SRN:	A4G23_04818

SGS:	AVL59_26770

SALU:

DC74_296

SALL:

SAZ_01935

SSIA:

A7J05_34625

SPUN:

BFF78_39735

SGV:	B1H19_02835 B1H19_37505

SLAU:

SLA_2552

SLX:	SLAV_12475

SGE:	DWG14_07853

SLK:	SLUN_02675

SDX:	C4B68_39405

SCYA:

EJ357_25515

SAST:

CD934_31310

SGZ:	C0216_06100

SVN:	CP980_02825

SFIC:

EIZ62_17690

SBY:	H7H31_00035 H7H31_08660 H7H31_19485

SSUB:

CP968_10475

SCHA:

CP983_19785

SGX:	H4W23_11125

SSPB:

CP982_02350

SNF:	JYK04_05848 JYK04_07984

SBRO:

GQF42_05400

SHUN:

DWB77_02434

SFEU:

IM697_43410

SFB:	CP974_25780

SHK:	J2N69_29170

SGOB:

test1122_04680

SLF:	JEQ17_48465

SDUR:

M4V62_06455

SYAN:

NRK68_32845

STAA:

LDH80_28230

SXT:	KPP03845_105191

SLON:

LGI35_44000

SHAU:

K9S39_12100

SROC:

RGF97_24960

STTN:

BSL84_32805

SINN:

ABB07_35520

STPB:

QR97_36435

SMIB:

SMIR_41310 SMIR_42385

SCAJ:

O1G22_38460

STII:

DRB96_18420 DRB96_31100

STIC:

DRB89_23820 DRB89_30240

SABD:

N8I86_03890

SMOD:

POD33_11420

SSOC:

ABZO31_08765

SSLI:

R2D22_11360

STYI:

C9F11_01985

SSIR:

WAB15_03160

SCT:	SCAT_0901 SCAT_4268

SCY:	SCATT_02100 SCATT_09020 SCATT_42550

KIT:	CFP65_5976 CFP65_6205

KCM:	ABWK59_26820

KNB:	ACF9IK_07910

STRH:

GXP74_30940

NAL:	B005_4463(albC)

NOA:	BKM31_22265

AMYC:

CU254_04905

AORI:

SD37_03085

APRE:

CNX65_23090

AMI:

Amir_4627

SESP:

BN6_23810

KPHY:

AOZ06_24710 AOZ06_47915

LED:	BBK82_41775

ACTI:

UA75_17765

ACAD:

UA74_17230

SACE:

GIY23_12525

MSAG:

GCM10017556_38040

AEY:	CDG81_12915

» show all

Reference

1 [PMID:19430487]

Authors

Gondry M, Sauguet L, Belin P, Thai R, Amouroux R, Tellier C, Tuphile K, Jacquet M, Braud S, Courcon M, Masson C, Dubois S, Lautru S, Lecoq A, Hashimoto S, Genet R, Pernodet JL

Title

Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.

Journal

Nat Chem Biol 5:414-20 (2009)
DOI:10.1038/nchembio.175

Sequence

[mtu:Rv2275]

Reference

2 [PMID:20852636]

Authors

Vetting MW, Hegde SS, Blanchard JS

Title

The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase.