Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy

L-leucyl-tRNALeu:L-leucyl-tRNALeu leucyltransferase (cyclizing)

2 L-leucyl-tRNALeu = 2 tRNALeu + cyclo(L-leucyl-L-leucyl) [RN:R10336]

R10336
Reaction

L-leucyl-tRNA(Leu) [CPD:C02047]

The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-leucine residue [2]. The proteins from bacteria of the genus Bacillus also form small amounts of cyclo(L-phenylalanyl-L-leucyl) and cyclo(L-leucyl-L-methionyl) [1].

EC 2.3.2.22 created 2013

1  [PMID:19430487]

Gondry M, Sauguet L, Belin P, Thai R, Amouroux R, Tellier C, Tuphile K, Jacquet M, Braud S, Courcon M, Masson C, Dubois S, Lautru S, Lecoq A, Hashimoto S, Genet R, Pernodet JL

Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.

Nat Chem Biol 5:414-20 (2009)
DOI:10.1038/nchembio.175

[bsu:BSU35070] [plu:plu0297]

2  [PMID:21325056]

Bonnefond L, Arai T, Sakaguchi Y, Suzuki T, Ishitani R, Nureki O

Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog.

Proc Natl Acad Sci U S A 108:3912-7 (2011)
DOI:10.1073/pnas.1019480108

[bli:BL00817]