KEGG ENZYME: 2.4.1.37

ENZYME: 2.4.1.37

Entry

EC 2.4.1.37                 Enzyme

Name

fucosylgalactoside 3-alpha-galactosyltransferase;
UDP-galactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase;
UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase;
[blood group substance] alpha-galactosyltransferase;
blood-group substance B-dependent galactosyltransferase;
glycoprotein-fucosylgalactoside alpha-galactosyltransferase;
histo-blood group B transferase;
histo-blood substance B-dependent galactosyltransferase;
UDP-galactose:alpha-L-fucosyl-1,2-D-galactoside 3-alpha-D-galactosyltransferase;
UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase

Reaction(IUBMB)

UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) [RN:R04548]

Reaction(KEGG)

R04548 > R06029(G) R06168(G) R06190(G) R13172(G)

Substrate

UDP-alpha-D-galactose [CPD:C00052];
alpha-L-fucosyl-(1->2)-D-galactosyl-R [CPD:C04648]

Product

UDP [CPD:C00015];
alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R [CPD:C04866]

Comment

Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.

History

EC 2.4.1.37 created 1972, modified 1999, modified 2002

Pathway

ec00601

Glycosphingolipid biosynthesis - lacto and neolacto series

ec00603

Glycosphingolipid biosynthesis - globo and isoglobo series

ec01100

Metabolic pathways

Orthology

K00709

histo-blood group ABO system transferase

Genes

HSA:

28(ABO)

PTR:	129388388(ABO) 450164

PPS:	100970130(ABO)

PON:	100454822(ABO)

PPYG:

129043934(ABO)

NLE:	115836398(ABO)

HMH:	116475813(ABO)

SSYN:

129478735(ABO)

MCC:	722252(ABO)

MCF:	135968616(ABO)

MTHB:

126937025

MNI:	105495555(ABO)

CSAB:

103239700(ABO)

CATY:

105594179(ABO)

PANU:

101008634(ABO)

TGE:	112608047(ABO)

MLEU:

105542951(ABO)

RRO:	104669731(ABO)

RBB:	108512581 108513461(ABO)

TFN:	117073926(ABO) 117084469

PTEH:

111523986 113223108 116418560

CANG:

105503987(ABO)

CJC:	100414456(ABO)

CIMI:

108298719(ABO) 108299003

ANAN:

105711513 135268125(ABO)

CSYR:

103250932(ABO)

MMUR:

105876954 105880740 105880771(ABO)

LCAT:

123624234 123624235 123624502 123646620(ABO)

PCOQ:

105826691(ABO)

OGA:	100957338 100957637 105887602

MMU:	80908(Abo)

MCAL:

110289771(Abo)

MPAH:

110315370 110319406(Abo)

RNO:	100301568(Abo) 296504(Abo2) 65270(Abo3)

MCOC:

116091605 116091607(Abo)

ANU:	117703701(Abo) 117703959 117711165 117711206 117711208

MUN:	110544720 132655966

CGE:	100754666 100757742 100758032 100772592(Abo)

MAUA:

101830897 106022281 110343791 121136014 121140321 121140322

PROB:

127222639 127222640 127222644 127238650 127238902

PLEU:

114684223 114686950 114686951 114692827 114698882 114698883

MORG:

121449973 121462665 121462666 121462744 121462814

MFOT:

126486698 126486699 126496363 126509203 126509335 126509336

AAMP:

119818823 119819595 119819744 119821887

NGI:	103740691(Abo)

HGL:

106010599

CCAN:

109683353 109696117(Abo)

DORD:

105989363 105995629

DSP:	122108875 122108883 122108982 122109075 122109078

PLOP:

125350807(Abo) 125353251

NCAR:

124966072 124966073

MMMA:

107151684(Abo)

OCU:	100337847 100338543 100352380 108175433

OPI:	101526707 101528259 101528504 101528819 101533919(GBGT1)

TUP:	102470199 102471037

GVR:

103581734

CFA:	100685413 111095419 119880300 491265(ABO)

CLUD:

112645543 112645544 112677406(ABO)

VVP:	112906902(ABO)

VLG:	121473070(ABO) 121479282 121487042

NPO:	129499129 129500147 129500148 129523345 129523438(ABO)

AML:	100466091 105235331

UMR:	103670246 103673989 103679933

UAH:	113266557 113266558

UAR:	123775732 123775738 123791709 123791710 123791716 123792854

LLV:	125082917 125106295

MPUF:

101679038 101689999(ABO) 106004543

MNP:	132024288(ABO)

MLK:	131812275(ABO) 131818655

NVS:	122917133(ABO)

ORO:	101364486 101369984 101372255 101374892 101377160 101380669 101381173 101382297 105758002

EJU:	114204063 114204164 114211218

ZCA:	113908490 113912178(ABO) 113933904 113939818 118356212 118356899 118357368

MLX:	118007373 118007385 118008661 118011058 118013990 118015321 118015336 118017553 118018074 118026207 118026209 118026766

NSU:	110581635 123324868

LWW:

102731903

FCA:	101087791 123381655

PYU:	121011349 121021218 121024182

PCOO:

112864870

PBG:	122474447 122474451 122474550 122475149

PVIV:

125150244 125150699

LRUF:

124511764 124522338 124522340 124522341 124522342 124522343 124522405 124522441 124522446 124525617 124525618 124525619 124525620

PPAD:

109258275(ABO)

PUC:	125923169 125923176

AJU:

106989205

HHV:	120227623 120227624 120227830

BTA:	515340(ABO)

BOM:	102283688(ABO)

BIU:	109565683(ABO)

BBUB:

102414923(ABO)

BBIS:

104983689

CHX:	102168916(ABO)

OAS:	101114008(ABO)

BTAX:

128055760(ABO)

ODA:	120852322(ABO)

CCAD:

122421289 122442346

MBEZ:

129547329

SSC:	396713(ABO)

CFR:	102523444(ABO)

CBAI:

105069746

CDK:	105105838(ABO)

VPC:	102537037(ABO)

BACU:

102997485

BMUS:

118897474(ABO)

DLE:	111171008(ABO)

PCAD:

102987697(ABO)

NASI:

112411476(ABO)

ECB:	100147494 102149124(ABO) 111767452

EPZ:	103542251 103542252 103547710 103565343(ABO)

EAI:	106829212 106829214 106845296 106845360 123275605

MYB:	102239108(ABO) 102250048

MYD:	102751691 102765942(ABO)

MMYO:

118666916(ABO)

MLF:	102435523 102436658 102436972

MDT:	132212524(ABO) 132212536

PKL:	118708875 118708888

EFUS:

103296154(ABO) 114226776

MNA:	107524627(ABO)

DRO:	112320051(ABO)

SHON:

118982529(ABO)

AJM:	119037339(ABO)

PDIC:

114510857(ABO)

PHAS:

123823700(ABO)

MMF:	118629595(ABO) 118629684

PPAM:

129079461(ABO)

RFQ:	117031856(ABO)

TOD:	119230358(ABO) 119231020 119250209

LAV:	100670655(ABO)

TMU:	101341957 101344015 101351903 101353602 101353733 101356026

ETF:	101660827(ABO)

DNM:	101413351 101421983

MDO:	100017917(ABO)

GAS:	123235204(ABO)

PCW:	110205086(ABO)

TVP:	118842289(ABO)

OAA:	100075215 100092870

TGU:

100223725

LSR:

110480583

SCAN:

103821701

PMOA:

120496584

OTC:

121347679

PRUF:

121351121 121354041

GFR:

102039105

FAB:

101817249

OMA:

130263929

PHI:

102113787

PMAJ:

107215091

CCAE:

111940162

CCW:

104697784

CBRC:

103624609

ZAB:	102063040(ABO)

ZLE:

135458554

SVG:

106863999

HRT:

120763820

SATI:

136372277

ACUN:

113484656

GCL:

127026728

DPUB:

104299235

AVIT:

104272769

PCRI:

104028332

PADL:

103917374

AFOR:

103893960

FGA:

104080004

GSTE:

104256454

MUI:	104538838(ABO)

CUCA:

104054434

TEO:

104380311

BREG:

104633466

CVF:

104290417

RTD:

128919437

AAM:

106488041

PSS:	102449345 102451371 102455524 102462837(ABO) 106732582

DCC:	119841969 119844210(ABO)

CPIC:

101943564 101944820 101945105 101953665

TST:

117885399

CABI:

116816446 116817454 116823991

MRV:	120386651 120386990 120386991

HCG:	128338753(ABO)

GJA:	107119149(ABO) 107125123

STOW:

125441582(ABO)

EMC:	129341921 129342153 129342164 129342498

XLA:	108698211(abo.2.L) 108698863(abo.4.L) 108699511(abo.5.L) 108699512(abo.6.L) 108699928(abo.6.S) 108714350 108715628 495825(abo.3.L)

XTR:	100488200 100491571 100491742 100491908 100492744 100492907 100497509(abo.4) 101734865 116406760 549437(abo.3) 549858(abo.2) 550054(abo.1)

NPR:	108791544 108791554 108793312 108793313 108801426 108803271

RTEM:

120913786 120914023 120914065

BBUF:

120977361 120977362 120977364 120977397 120977991 121009511

BGAR:

122919453 122919647 122919883 122922624 122945936 122946179 122946259 122946276 122946277 122946287 122946310 122946643 122946791

MUO:	115465006 115466314 115466315 115466325 115466332 115466333 115466334 115472537 115473094 115473095 115473097

GSH:	117346320 117346602 117346605 117346607 117346609 117367697 117368381

SRX:	107747826 107747839

SANH:

107680349 107687664 107687695 107694233

SGH:	107569538 107581033 107592359

CCAR:

109056910

CAUA:

113039522 113039523 113039530 113048792

EEE:	113569626 113583526

OMY:

110525108

SALP:

112074307

BFO:

118403702

GAE:

121392028

» show all

Reference

1 [PMID:16742598]

Authors

Race C, Ziderman D, Watkins WM.

Title

An alpha-d-galactosyltransferase associated with the blood-group B character.

Journal

Biochem J 107:733-735 (1968)
DOI:10.1042/bj1070733

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.37

IUBMB Enzyme Nomenclature:

2.4.1.37

ExPASy - ENZYME nomenclature database:

2.4.1.37

BRENDA, the Enzyme Database:

2.4.1.37

CAS:	37257-33-3

LinkDB

DBGET integrated database retrieval system